Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 13-1329-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD132 Monoclonal Antibody (TUGh4), Biotin, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This TUGh4 monoclonal antibody reacts with human CD132, the common gamma chain (gamma c) shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors. This approximately 65 kDa receptor component is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. Mutations in the human gamma chain gene result in X-linked severe combined immunodeficiency (XSCID), a disease characterized by T cell deficiency leading to impairment of cell-mediated and humoral immunity.
- Conjugate
- Biotin
- Antibody clone number
- TUGh4
- Concentration
- 0.5 mg/mL
Submitted references The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.
Expression of the IL-2 receptor gamma chain on various populations in human peripheral blood.
Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T
Annual review of immunology 1996;14:179-205
Annual review of immunology 1996;14:179-205
Expression of the IL-2 receptor gamma chain on various populations in human peripheral blood.
Ishii N, Takeshita T, Kimura Y, Tada K, Kondo M, Nakamura M, Sugamura K
International immunology 1994 Aug;6(8):1273-7
International immunology 1994 Aug;6(8):1273-7
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of normal human peripheral blood cells with anti-human CD4 eFluor® 450 (Product # 48-0049-42) and Rat IgG2b K Isotype Control Biotin (Product # 13-4031-82) (left) or Anti-Human CD132 Biotin (right) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Biotin