13-1329-80

antibody from Invitrogen Antibodies

Targeting: IL2RG CD132, CIDX, IMD4, SCIDX1

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

13-1329-80

Provider

Invitrogen Antibodies

Product name

CD132 Monoclonal Antibody (TUGh4), Biotin, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: This TUGh4 monoclonal antibody reacts with human CD132, the common gamma chain (gamma c) shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors. This approximately 65 kDa receptor component is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. Mutations in the human gamma chain gene result in X-linked severe combined immunodeficiency (XSCID), a disease characterized by T cell deficiency leading to impairment of cell-mediated and humoral immunity.

Conjugate

Biotin

Antibody clone number

TUGh4

Concentration

0.5 mg/mL

References

Submitted references

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.

Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, Nakamura M, Takeshita T
Annual review of immunology 1996;14:179-205

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Expression of the IL-2 receptor gamma chain on various populations in human peripheral blood.

Ishii N, Takeshita T, Kimura Y, Tada K, Kondo M, Nakamura M, Sugamura K
International immunology 1994 Aug;6(8):1273-7

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with anti-human CD4 eFluor® 450 (Product # 48-0049-42) and Rat IgG2b K Isotype Control Biotin (Product # 13-4031-82) (left) or Anti-Human CD132 Biotin (right) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.

Conjugate

Biotin