130-10013-100

antibody from RayBiotech, Inc.

Targeting: CTF1 CT-1, CT1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

130-10013-100

Provider

RayBiotech, Inc.

Product name

Rabbit Anti-Human CT1

Antibody type

Polyclonal

Antigen

Immunogen was expressing Human CT-1 protein.

Description

Cardiotrophin-1 (CT-1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes. Studies have revealed CT-1 is highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. This antibody was produced from a rabbit immunized

Reactivity

Human

Host

Rabbit

Antigen sequence

This antibody was produced from a r
abbit immunized


Isotype

IgG

Vial size

100 µg

Handling

Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, liking Sodium Azide. The final concentration is indicated on the shipping vial. Please avoid freeze-thaw cycles. The antibody is stable for at least years from the data of receipt when stored at -200C to -700C. Reconstituted antibody (suggesting with sterile PBS) can also be aliquotted and stored frozen at -200C to -700C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can be stored at 40C for 1 month.