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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF438 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Cardiotrophin-1/CT-1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects Cardiotrophin-1/CT-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human CT-1 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q60753- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning.
In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice.
In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice.
Iñiguez M, Berasain C, Martinez-Ansó E, Bustos M, Fortes P, Pennica D, Avila MA, Prieto J
The Journal of experimental medicine 2006 Dec 25;203(13):2809-15
The Journal of experimental medicine 2006 Dec 25;203(13):2809-15
In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice.
Lesbordes JC, Bordet T, Haase G, Castelnau-Ptakhine L, Rouhani S, Gilgenkrantz H, Kahn A
Human molecular genetics 2002 Jul 1;11(14):1615-25
Human molecular genetics 2002 Jul 1;11(14):1615-25
In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice.
Lesbordes JC, Bordet T, Haase G, Castelnau-Ptakhine L, Rouhani S, Gilgenkrantz H, Kahn A
Human molecular genetics 2002 Jul 1;11(14):1615-25
Human molecular genetics 2002 Jul 1;11(14):1615-25
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by Cardiotrophin-1/CT-1 and Neutralization by Mouse Cardiotrophin-1/CT-1 Antibody. Recombinant Mouse Cardiotrophin-1/CT-1 (Catalog # 438-CT) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse Cardiotrophin-1/CT-1 (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse Cardiotrophin-1/CT-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF438). The ND50 is typically 0.08-0.48 µg/mL.
