Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5637 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- CA6 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to the 263-308 of Human CA6.
- Description
- Carbonic anhydrase VI (CA VI) contributes to taste function when secreted in the saliva by protecting taste receptor cells (TRCs) from apoptosis. Functional CA VI exists as a single polypeptide chain tightly bound to one molecule of zinc, and containing two N-linked glycosylation sites. Decreased CA VI secretion correlates with loss of taste (hypogeusia) and smell (hyposmia) or distorted taste (dysgeusia) and smell (dysosmia), and altered taste bud morphology. Addition of zinc to individuals experiencing these symptoms restored secretion of CA VI to normal levels and normal taste bud morphology in some, but not all, cases, indicating two different mechanisms leading to CA VI dysfunction.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of CA6 pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:sp2/0 cell lysateLane3:H9C2 cell lysate