Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 15527-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15527-1-AP, RRID:AB_2172168
- Product name
- PRSS8 antibody
- Antibody type
- Polyclonal
- Description
- PRSS8 antibody (Cat. #15527-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.
Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels.
The epithelial Na+ channel α- and γ-subunits are cleaved at predicted furin-cleavage sites, glycosylated and membrane associated in human kidney.
Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel.
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.
Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.
Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.
Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.
Essigke D, Ilyaskin AV, Wörn M, Bohnert BN, Xiao M, Daniel C, Amann K, Birkenfeld AL, Szabo R, Bugge TH, Korbmacher C, Artunc F
Acta physiologica (Oxford, England) 2021 May;232(1):e13640
Acta physiologica (Oxford, England) 2021 May;232(1):e13640
Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels.
Wu MM, Liang C, Yu XD, Song BL, Yue Q, Zhai YJ, Linck V, Cai YX, Niu N, Yang X, Zhang BL, Wang QS, Zou L, Zhang S, Thai TL, Ma J, Sutliff RL, Zhang ZR, Ma HP
British journal of pharmacology 2019 Sep;176(18):3695-3711
British journal of pharmacology 2019 Sep;176(18):3695-3711
The epithelial Na+ channel α- and γ-subunits are cleaved at predicted furin-cleavage sites, glycosylated and membrane associated in human kidney.
Zachar R, Mikkelsen MK, Skjødt K, Marcussen N, Zamani R, Jensen BL, Svenningsen P
Pflugers Archiv : European journal of physiology 2019 Dec;471(11-12):1383-1396
Pflugers Archiv : European journal of physiology 2019 Dec;471(11-12):1383-1396
Albuminuria in kidney transplant recipients is associated with increased urinary serine proteases and activation of the epithelial sodium channel.
Hinrichs GR, Michelsen JS, Zachar R, Friis UG, Svenningsen P, Birn H, Bistrup C, Jensen BL
American journal of physiology. Renal physiology 2018 Jul 1;315(1):F151-F160
American journal of physiology. Renal physiology 2018 Jul 1;315(1):F151-F160
Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin.
Oxlund C, Kurt B, Schwarzensteiner I, Hansen MR, Stæhr M, Svenningsen P, Jacobsen IA, Hansen PB, Thuesen AD, Toft A, Hinrichs GR, Bistrup C, Jensen BL
Pflugers Archiv : European journal of physiology 2017 Jun;469(5-6):655-667
Pflugers Archiv : European journal of physiology 2017 Jun;469(5-6):655-667
Prostasin and matriptase (ST14) in placenta from preeclamptic and healthy pregnant women.
Frederiksen-Møller B, Jørgensen JS, Hansen MR, Krigslund O, Vogel LK, Andersen LB, Jensen BL
Journal of hypertension 2016 Feb;34(2):298-306
Journal of hypertension 2016 Feb;34(2):298-306
Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells.
Andersen H, Friis UG, Hansen PB, Svenningsen P, Henriksen JE, Jensen BL
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015 May;30(5):781-9
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015 May;30(5):781-9
Increased expression of prostasin contributes to early-onset severe preeclampsia through inhibiting trophoblast invasion.
Yang Y, Zhang J, Gong Y, Liu X, Bai Y, Xu W, Zhou R
Journal of perinatology : official journal of the California Perinatal Association 2015 Jan;35(1):16-22
Journal of perinatology : official journal of the California Perinatal Association 2015 Jan;35(1):16-22
Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epithelium.
Steensgaard M, Svenningsen P, Tinning AR, Nielsen TD, Jørgensen F, Kjaersgaard G, Madsen K, Jensen BL
Acta physiologica (Oxford, England) 2010 Dec;200(4):347-59
Acta physiologica (Oxford, England) 2010 Dec;200(4):347-59
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human colon tissue were subjected to SDS PAGE followed by western blot with 15527-1-AP(PRSS8 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 15527-1-AP(PRSS8 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRSS8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRSS8. This antibody recognizes human,mouse,rat antigen. The PRSS8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.