ADAMTS7

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]

Description

ADAM metallopeptidase with thrombospondin type 1 motif 7

Tissue specificity

Tissue enhanced (heart muscle)

Subcell location

Vesicles

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

15 (78759206 - 78811464)

Ensembl ID

ENSG00000136378  (ver. 103.38)

Orthologs

Mouse Adamts7: ENSMUSG00000032363

UniProt

Q9UKP4

neXtProt

NX_Q9UKP4

Human splice variants
Mouse splice variants

Protein structure