CMTM7

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Description

CKLF like MARVEL transmembrane domain containing 7

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

3 (32391698 - 32483067)

Ensembl ID

ENSG00000153551  (ver. 103.38)

Orthologs

Mouse Cmtm7: ENSMUSG00000032436

UniProt

Q96FZ5

neXtProt

NX_Q96FZ5

Human splice variants
Mouse splice variants

Protein structure