Antibody data
- Antibody Data
- Antigen structure
- References [75]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
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- Product number
- 12422-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12422-1-AP, RRID:AB_2162467
- Product name
- Alix antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Alix antibody (Cat. #12422-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease.
Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles.
Development of a novel RNAi therapy: Engineered miR-31 exosomes promoted the healing of diabetic wounds.
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration.
A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Macrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis.
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles.
Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss.
Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.
TGF-β1-mediated exosomal lnc-MMP2-2 increases blood-brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer brain metastasis.
SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation.
EVs Containing Host Restriction Factor IFITM3 Inhibited ZIKV Infection of Fetuses in Pregnant Mice through Trans-placenta Delivery.
Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
RAB31 marks and controls an ESCRT-independent exosome pathway.
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.
Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.
Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.
Extracellular vesicles derived from lipoaspirate fluid promote fat graft survival.
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
The tissue origin effect of extracellular vesicles on cartilage and bone regeneration.
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
Similar Repair Effects of Human Placenta, Bone Marrow Mesenchymal Stem Cells, and Their Exosomes for Damaged SVOG Ovarian Granulosa Cells.
Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma.
Plasma Exosomal miRNA Expression Profile as Oxaliplatin-Based Chemoresistant Biomarkers in Colorectal Adenocarcinoma.
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes.
DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses.
Tuberous Sclerosis Complex Axis Controls Renal Extracellular Vesicle Production and Protein Content.
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma.
Circulating exosomal small RNAs are promising non-invasive diagnostic biomarkers for gastric cancer.
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.
Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis.
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.
KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling.
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues.
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo.
Cocktail Strategy Based on NK Cell-Derived Exosomes and Their Biomimetic Nanoparticles for Dual Tumor Therapy.
O-GlcNAcylation of Thr12/Ser56 in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.
Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis.
Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis.
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.
Cluster of Differentiation 46 Is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28).
Microvesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy.
Detection of exosomal tyrosine receptor kinase B as a potential biomarker in ovarian cancer.
Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α1-antitrypsin disposal.
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.
TGF-β-mediated exosomal lnc-MMP2-2 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression.
Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response.
Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling.
Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity.
Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer.
Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.
Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication.
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
REG3β modifies cell tumor function by impairing extracellular vesicle uptake.
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.
Involvement of exosomes in lung inflammation associated with experimental acute pancreatitis.
Regulation of exosomes released from normal ovarian epithelial cells and ovarian cancer cells.
EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance.
Characterization of exosomes derived from ovarian cancer cells and normal ovarian epithelial cells by nanoparticle tracking analysis.
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.
Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.
Carrascal M, Areny-Balagueró A, de-Madaria E, Cárdenas-Jaén K, García-Rayado G, Rivera R, Martin Mateos RM, Pascual-Moreno I, Gironella M, Abian J, Closa D
The Journal of pathology 2022 Jan;256(1):83-92
The Journal of pathology 2022 Jan;256(1):83-92
Tsc Gene Locus Disruption and Differences in Renal Epithelial Extracellular Vesicles.
Kumar P, Zadjali F, Yao Y, Siroky B, Astrinidis A, Gross KW, Bissler JJ
Frontiers in physiology 2021;12:630933
Frontiers in physiology 2021;12:630933
Development of a novel RNAi therapy: Engineered miR-31 exosomes promoted the healing of diabetic wounds.
Huang J, Yu M, Yin W, Liang B, Li A, Li J, Li X, Zhao S, Liu F
Bioactive materials 2021 Sep;6(9):2841-2853
Bioactive materials 2021 Sep;6(9):2841-2853
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Tang B, Song M, Xie X, Le D, Tu Q, Wu X, Chen M
Neurochemical research 2021 Sep;46(9):2387-2402
Neurochemical research 2021 Sep;46(9):2387-2402
Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration.
Yu H, Yang X, Xiao X, Xu M, Yang Y, Xue C, Li X, Wang S, Zhao RC
Aging and disease 2021 Sep;12(6):1423-1437
Aging and disease 2021 Sep;12(6):1423-1437
A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.
Liu W, Yu M, Chen F, Wang L, Ye C, Chen Q, Zhu Q, Xie D, Shao M, Yang L
Journal of nanobiotechnology 2021 Sep 7;19(1):269
Journal of nanobiotechnology 2021 Sep 7;19(1):269
Engineering Extracellular Vesicles Restore the Impaired Cellular Uptake and Attenuate Intervertebral Disc Degeneration.
Liao Z, Liu H, Ma L, Lei J, Tong B, Li G, Ke W, Wang K, Feng X, Hua W, Li S, Yang C
ACS nano 2021 Sep 28;15(9):14709-14724
ACS nano 2021 Sep 28;15(9):14709-14724
Macrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis.
Sun NN, Zhang Y, Huang WH, Zheng BJ, Jin SY, Li X, Meng Y
Chinese medical journal 2021 Sep 2;134(18):2175-2185
Chinese medical journal 2021 Sep 2;134(18):2175-2185
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles.
Fei X, Li Z, Yang D, Kong X, Lu X, Shen Y, Li X, Xie S, Wang J, Zhao Y, Sun Y, Zhang J, Ye Z, Wang J, Cai Z
Journal of extracellular vesicles 2021 Oct;10(12):e12153
Journal of extracellular vesicles 2021 Oct;10(12):e12153
Tenascin-C expression in the lymph node pre-metastatic niche in muscle-invasive bladder cancer.
Silvers CR, Messing EM, Miyamoto H, Lee YF
British journal of cancer 2021 Nov;125(10):1399-1407
British journal of cancer 2021 Nov;125(10):1399-1407
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss.
Lin L, Wang H, Guo W, He E, Huang K, Zhao Q
Cellular signalling 2021 Jun;82:109935
Cellular signalling 2021 Jun;82:109935
Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model.
Duan A, Shen K, Li B, Li C, Zhou H, Kong R, Shao Y, Qin J, Yuan T, Ji J, Guo W, Wang X, Xue T, Li L, Huang X, Sun Y, Cai Z, Liu W, Liu F
Stem cell research & therapy 2021 Jul 28;12(1):427
Stem cell research & therapy 2021 Jul 28;12(1):427
TGF-β1-mediated exosomal lnc-MMP2-2 increases blood-brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer brain metastasis.
Wu D, Deng S, Li L, Liu T, Zhang T, Li J, Yu Y, Xu Y
Cell death & disease 2021 Jul 20;12(8):721
Cell death & disease 2021 Jul 20;12(8):721
SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation.
Huang R, Hao C, Wang D, Zhao Q, Li C, Wang C, Yao W
Toxicology and applied pharmacology 2021 Jul 1;422:115559
Toxicology and applied pharmacology 2021 Jul 1;422:115559
EVs Containing Host Restriction Factor IFITM3 Inhibited ZIKV Infection of Fetuses in Pregnant Mice through Trans-placenta Delivery.
Zou X, Yuan M, Zhang T, Zheng N, Wu Z
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):176-190
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):176-190
Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke.
Yang J, Cao LL, Wang XP, Guo W, Guo RB, Sun YQ, Xue TF, Cai ZY, Ji J, Cheng H, Sun XL
Cell death & disease 2021 Jan 6;12(1):23
Cell death & disease 2021 Jan 6;12(1):23
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
RAB31 marks and controls an ESCRT-independent exosome pathway.
Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T
Cell research 2021 Feb;31(2):157-177
Cell research 2021 Feb;31(2):157-177
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.
Cao W, Zeng Z, He Z, Lei S
Aging 2021 Feb 26;13(5):7120-7132
Aging 2021 Feb 26;13(5):7120-7132
Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism.
Ochiai-Homma F, Kuribayashi-Okuma E, Tsurutani Y, Ishizawa K, Fujii W, Odajima K, Kawagoe M, Tomomitsu Y, Murakawa M, Asakawa S, Hirohama D, Nagura M, Arai S, Yamazaki O, Tamura Y, Fujigaki Y, Nishikawa T, Shibata S
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Dec;44(12):1557-1567
Hypertension research : official journal of the Japanese Society of Hypertension 2021 Dec;44(12):1557-1567
Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.
Yang J, Hu Y, Wang L, Sun X, Yu L, Guo W
Bioengineered 2021 Dec;12(2):11007-11017
Bioengineered 2021 Dec;12(2):11007-11017
Extracellular vesicles derived from lipoaspirate fluid promote fat graft survival.
Nie F, Ding P, Zhang C, Zhao Z, Bi H
Adipocyte 2021 Dec;10(1):293-309
Adipocyte 2021 Dec;10(1):293-309
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Zhao F, Zheng T, Gong W, Wu J, Xie H, Li W, Zhang R, Liu P, Liu J, Wu X, Zhao Y, Ren J
Cell death & disease 2021 Aug 27;12(9):815
Cell death & disease 2021 Aug 27;12(9):815
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Luo L, Jian X, Sun H, Qin J, Wang Y, Zhang J, Shen Z, Yang D, Li C, Zhao P, Liu M, Tian Z, Zhou Y
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481
Stem cells (Dayton, Ohio) 2021 Apr;39(4):467-481
The tissue origin effect of extracellular vesicles on cartilage and bone regeneration.
Li Q, Yu H, Sun M, Yang P, Hu X, Ao Y, Cheng J
Acta biomaterialia 2021 Apr 15;125:253-266
Acta biomaterialia 2021 Apr 15;125:253-266
Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles.
Jiang W, Ma P, Deng L, Liu Z, Wang X, Liu X, Long G
Journal of extracellular vesicles 2020;9(1):1716513
Journal of extracellular vesicles 2020;9(1):1716513
Similar Repair Effects of Human Placenta, Bone Marrow Mesenchymal Stem Cells, and Their Exosomes for Damaged SVOG Ovarian Granulosa Cells.
Chen S, Wang Y, Liao L, Meng L, Li J, Shi C, Han H, Zheng X, Shen H
Stem cells international 2020;2020:8861557
Stem cells international 2020;2020:8861557
Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma.
Zhang K, Dong C, Chen M, Yang T, Wang X, Gao Y, Wang L, Wen Y, Chen G, Wang X, Yu X, Zhang Y, Wang P, Shang M, Han K, Zhou Y
Theranostics 2020;10(1):411-425
Theranostics 2020;10(1):411-425
Plasma Exosomal miRNA Expression Profile as Oxaliplatin-Based Chemoresistant Biomarkers in Colorectal Adenocarcinoma.
Han J, Sun W, Liu R, Zhou Z, Zhang H, Chen X, Ba Y
Frontiers in oncology 2020;10:1495
Frontiers in oncology 2020;10:1495
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
Matic S, D'Souza DH, Wu T, Pangloli P, Dia VP
Immunological investigations 2020 Oct;49(7):711-725
Immunological investigations 2020 Oct;49(7):711-725
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
Jiang L, Zhang Y, Liu T, Wang X, Wang H, Song H, Wang W
Biochimie 2020 Oct;177:40-49
Biochimie 2020 Oct;177:40-49
Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes.
Cao Q, Liu Y, Wu Y, Hu C, Sun L, Wang J, Li C, Guo M, Liu X, Lv J, Huo X, Yue J, Du X, Chen Z
Aging 2020 Nov 21;12(24):25981-25999
Aging 2020 Nov 21;12(24):25981-25999
DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses.
Hitomi K, Okada R, Loo TM, Miyata K, Nakamura AJ, Takahashi A
International journal of molecular sciences 2020 May 25;21(10)
International journal of molecular sciences 2020 May 25;21(10)
Tuberous Sclerosis Complex Axis Controls Renal Extracellular Vesicle Production and Protein Content.
Zadjali F, Kumar P, Yao Y, Johnson D, Astrinidis A, Vogel P, Gross KW, Bissler JJ
International journal of molecular sciences 2020 Mar 3;21(5)
International journal of molecular sciences 2020 Mar 3;21(5)
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Extracellular vesicles transmitted miR-31-5p promotes sorafenib resistance by targeting MLH1 in renal cell carcinoma.
He J, He J, Min L, He Y, Guan H, Wang J, Peng X
International journal of cancer 2020 Feb 15;146(4):1052-1063
International journal of cancer 2020 Feb 15;146(4):1052-1063
Circulating exosomal small RNAs are promising non-invasive diagnostic biomarkers for gastric cancer.
Ge L, Zhang N, Li D, Wu Y, Wang H, Wang J
Journal of cellular and molecular medicine 2020 Dec;24(24):14502-14513
Journal of cellular and molecular medicine 2020 Dec;24(24):14502-14513
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Sha L, Ma D, Chen C
Aging 2020 Dec 13;12(23):23598-23608
Aging 2020 Dec 13;12(23):23598-23608
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.
Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, Roux A
Nature cell biology 2020 Aug;22(8):947-959
Nature cell biology 2020 Aug;22(8):947-959
Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis.
Xiang E, Han B, Zhang Q, Rao W, Wang Z, Chang C, Zhang Y, Tu C, Li C, Wu D
Stem cell research & therapy 2020 Aug 3;11(1):336
Stem cell research & therapy 2020 Aug 3;11(1):336
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway.
Yu M, Liu W, Li J, Lu J, Lu H, Jia W, Liu F
Stem cell research & therapy 2020 Aug 12;11(1):350
Stem cell research & therapy 2020 Aug 12;11(1):350
KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling.
Li Y, Yu S, Li L, Chen J, Quan M, Li Q, Gao Y
Cell death & disease 2020 Apr 29;11(4):299
Cell death & disease 2020 Apr 29;11(4):299
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, Qu Y, Zhao Y, Huang R, Wei J, Yao W
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues.
Zou X, Yuan M, Zhang T, Wei H, Xu S, Jiang N, Zheng N, Wu Z
Theranostics 2019;9(19):5657-5671
Theranostics 2019;9(19):5657-5671
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo.
Liao Z, Luo R, Li G, Song Y, Zhan S, Zhao K, Hua W, Zhang Y, Wu X, Yang C
Theranostics 2019;9(14):4084-4100
Theranostics 2019;9(14):4084-4100
Cocktail Strategy Based on NK Cell-Derived Exosomes and Their Biomimetic Nanoparticles for Dual Tumor Therapy.
Wang G, Hu W, Chen H, Shou X, Ye T, Xu Y
Cancers 2019 Oct 14;11(10)
Cancers 2019 Oct 14;11(10)
O-GlcNAcylation of Thr12/Ser56 in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.
Liu L, Li L, Ma C, Shi Y, Liu C, Xiao Z, Zhang Y, Tian F, Gao Y, Zhang J, Ying W, Wang PG, Zhang L
The Journal of biological chemistry 2019 Nov 8;294(45):16620-16633
The Journal of biological chemistry 2019 Nov 8;294(45):16620-16633
Exosomes derived from human CD34+ stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis.
Zuo R, Kong L, Wang M, Wang W, Xu J, Chai Y, Guan J, Kang Q
Stem cell research & therapy 2019 Nov 15;10(1):321
Stem cell research & therapy 2019 Nov 15;10(1):321
Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis.
Zhang W, Peng P, Ou X, Shen K, Wu X
BMC cancer 2019 Nov 12;19(1):1095
BMC cancer 2019 Nov 12;19(1):1095
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses.
Zhang F, Li R, Yang Y, Shi C, Shen Y, Lu C, Chen Y, Zhou W, Lin A, Yu L, Zhang W, Xue Z, Wang J, Cai Z
Immunity 2019 Mar 19;50(3):738-750.e7
Immunity 2019 Mar 19;50(3):738-750.e7
The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.
Wei S, Zheng Y, Jiang Y, Li X, Geng J, Shen Y, Li Q, Wang X, Zhao C, Chen Y, Qian Z, Zhou J, Li W
EBioMedicine 2019 Jun;44:182-193
EBioMedicine 2019 Jun;44:182-193
Cluster of Differentiation 46 Is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28).
Kuroda H, Tachikawa M, Yagi Y, Umetsu M, Nurdin A, Miyauchi E, Watanabe M, Uchida Y, Terasaki T
Molecular pharmaceutics 2019 Jan 7;16(1):292-304
Molecular pharmaceutics 2019 Jan 7;16(1):292-304
Microvesicle-Mediated Delivery of Minicircle DNA Results in Effective Gene-Directed Enzyme Prodrug Cancer Therapy.
Kanada M, Kim BD, Hardy JW, Ronald JA, Bachmann MH, Bernard MP, Perez GI, Zarea AA, Ge TJ, Withrow A, Ibrahim SA, Toomajian V, Gambhir SS, Paulmurugan R, Contag CH
Molecular cancer therapeutics 2019 Dec;18(12):2331-2342
Molecular cancer therapeutics 2019 Dec;18(12):2331-2342
Detection of exosomal tyrosine receptor kinase B as a potential biomarker in ovarian cancer.
Li W, Lu Y, Yu X, Yong M, Ma D, Gao Q
Journal of cellular biochemistry 2019 Apr;120(4):6361-6369
Journal of cellular biochemistry 2019 Apr;120(4):6361-6369
Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α1-antitrypsin disposal.
Khodayari N, Oshins R, Alli AA, Tuna KM, Holliday LS, Krotova K, Brantly M
The Journal of biological chemistry 2019 Apr 19;294(16):6240-6252
The Journal of biological chemistry 2019 Apr 19;294(16):6240-6252
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.
Huang H, Zheng X, Cai C, Yao Z, Lu S, Meng X, Miao Y, He Z, Cai C, Zou F
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248
TGF-β-mediated exosomal lnc-MMP2-2 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression.
Wu DM, Deng SH, Liu T, Han R, Zhang T, Xu Y
Cancer medicine 2018 Oct;7(10):5118-5129
Cancer medicine 2018 Oct;7(10):5118-5129
Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response.
Mittal E, Skowyra ML, Uwase G, Tinaztepe E, Mehra A, Köster S, Hanson PI, Philips JA
mBio 2018 Nov 27;9(6)
mBio 2018 Nov 27;9(6)
Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling.
Ringuette Goulet C, Bernard G, Tremblay S, Chabaud S, Bolduc S, Pouliot F
Molecular cancer research : MCR 2018 Jul;16(7):1196-1204
Molecular cancer research : MCR 2018 Jul;16(7):1196-1204
Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity.
Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, Shen F, Shi B, Liu J, Peng L, Li J, Yuan Z
Journal of virology 2018 Dec 15;92(24)
Journal of virology 2018 Dec 15;92(24)
Circulating Exosomal miR-17-5p and miR-92a-3p Predict Pathologic Stage and Grade of Colorectal Cancer.
Fu F, Jiang W, Zhou L, Chen Z
Translational oncology 2018 Apr;11(2):221-232
Translational oncology 2018 Apr;11(2):221-232
Characterization of urinary extracellular vesicle proteins in muscle-invasive bladder cancer.
Silvers CR, Miyamoto H, Messing EM, Netto GJ, Lee YF
Oncotarget 2017 Oct 31;8(53):91199-91208
Oncotarget 2017 Oct 31;8(53):91199-91208
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Scientific reports 2017 Nov 23;7(1):16120
Scientific reports 2017 Nov 23;7(1):16120
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
Takahashi A, Okada R, Nagao K, Kawamata Y, Hanyu A, Yoshimoto S, Takasugi M, Watanabe S, Kanemaki MT, Obuse C, Hara E
Nature communications 2017 May 16;8:15287
Nature communications 2017 May 16;8:15287
REG3β modifies cell tumor function by impairing extracellular vesicle uptake.
Bonjoch L, Gironella M, Iovanna JL, Closa D
Scientific reports 2017 Jun 9;7(1):3143
Scientific reports 2017 Jun 9;7(1):3143
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
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Nature communications 2017 Jun 6;8:15729
Nature communications 2017 Jun 6;8:15729
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Zhang J, Lu S, Zhou Y, Meng K, Chen Z, Cui Y, Shi Y, Wang T, He QY
Proteomics 2017 Jul;17(13-14)
Proteomics 2017 Jul;17(13-14)
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Bonjoch L, Casas V, Carrascal M, Closa D
The Journal of pathology 2016 Oct;240(2):235-45
The Journal of pathology 2016 Oct;240(2):235-45
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Zhang W, Yang J, Cao D, You Y, Shen K, Peng P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct 6;
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct 6;
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Jiang L, Shen Y, Guo D, Yang D, Liu J, Fei X, Yang Y, Zhang B, Lin Z, Yang F, Wang X, Wang K, Wang J, Cai Z
Nature communications 2016 Oct 10;7:13045
Nature communications 2016 Oct 10;7:13045
Characterization of exosomes derived from ovarian cancer cells and normal ovarian epithelial cells by nanoparticle tracking analysis.
Zhang W, Peng P, Kuang Y, Yang J, Cao D, You Y, Shen K
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Mar;37(3):4213-21
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Mar;37(3):4213-21
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Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K
Journal of proteomics 2013 Mar 27;80:171-82
Journal of proteomics 2013 Mar 27;80:171-82
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Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z
Nature immunology 2013 Aug;14(8):793-803
Nature immunology 2013 Aug;14(8):793-803
Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.
Hopp K, Ward CJ, Hommerding CJ, Nasr SH, Tuan HF, Gainullin VG, Rossetti S, Torres VE, Harris PC
The Journal of clinical investigation 2012 Nov;122(11):4257-73
The Journal of clinical investigation 2012 Nov;122(11):4257-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 12422-1-AP(ALIX; AIP1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using PDCD6IP antibody 12422-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDCD6IP antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDCD6IP. This antibody recognizes human,mouse,rat antigen. The PDCD6IP antibody has been validated for the following applications: ELISA, IF, IP, WB analysis.