CABT-B123

antibody from Creative Diagnostics

Targeting: MOK RAGE, RAGE1, STK30

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B123

Provider

Creative Diagnostics

Product name

Anti-RAGE (V Domain) monoclonal antibody, clone 3B22

Antibody type

Monoclonal

Description

Advanced glycosylation end product-specific receptor (AGER, RAGE) mediates interactions of advanced glycosylation end products (AGE), nonenzymatically glycosylated proteins. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. RAGE acts as a receptor for amyloid beta peptide and contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane in cortical neurons. The V domain binds multiple ligands that elicit sustained inflammation associated with diabetes, cancer, Alzheimer's, multiple sclerosis, and other diseases.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3B22

Vial size

100_g

Storage

-20°C