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Learn2661
antibody from Cell Signaling Technology, Inc
Targeting: CHEK2
bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
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- Product number
- 2661 - Provider product page
- Provider
- Cell Signaling Technology, Inc
- Proper citation
- Cell Signaling Technology Cat#2661, RRID:AB_331479
- Product name
- Phospho-Chk2 (Thr68) Antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Simian
- Host
- Rabbit
- Storage
- -20°C
Submitted references Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
γH2AX, pChk1, and Wip1 as potential markers of persistent DNA damage derived from dibenzo[a,l]pyrene and PAH-containing extracts from contaminated soils.
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
Bartucci M, Svensson S, Romania P, Dattilo R, Patrizii M, Signore M, Navarra S, Lotti F, Biffoni M, Pilozzi E, Duranti E, Martinelli S, Rinaldo C, Zeuner A, Maugeri-Saccà M, Eramo A, De Maria R
Cell death and differentiation 2012 May;19(5):768-78
Cell death and differentiation 2012 May;19(5):768-78
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S
The EMBO journal 2012 Apr 18;31(8):1865-78
The EMBO journal 2012 Apr 18;31(8):1865-78
γH2AX, pChk1, and Wip1 as potential markers of persistent DNA damage derived from dibenzo[a,l]pyrene and PAH-containing extracts from contaminated soils.
Niziolek-Kierecka M, Dreij K, Lundstedt S, Stenius U
Chemical research in toxicology 2012 Apr 16;25(4):862-72
Chemical research in toxicology 2012 Apr 16;25(4):862-72
The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G
Oncogene 2004 May 27;23(25):4353-61
Oncogene 2004 May 27;23(25):4353-61
Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Yin MB, Li ZR, Cao S, Durrani FA, Azrak RG, Frank C, Rustum YM
Molecular pharmacology 2004 Jul;66(1):153-60
Molecular pharmacology 2004 Jul;66(1):153-60
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J
Nature cell biology 2003 Mar;5(3):255-60
Nature cell biology 2003 Mar;5(3):255-60
Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A
The Journal of biological chemistry 2002 Jul 19;277(29):26553-64
The Journal of biological chemistry 2002 Jul 19;277(29):26553-64
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