13954-1-AP
antibody from Proteintech Group
Targeting: CHEK2
bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 13954-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13954-1-AP, RRID:AB_10598159
- Product name
- CHEK2 antibody
- Antibody type
- Polyclonal
- Description
- CHEK2 antibody (Cat. #13954-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.
Chen Q, Wang Y, Jiao F, Cao P, Shi C, Pei M, Wang L, Gong Z
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
Journal of cellular and molecular medicine 2021 Aug;25(15):7218-7228
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Han B, Pei Z, Shi L, Wang Q, Li C, Zhang B, Su X, Zhang N, Zhou L, Zhao B, Niu Y, Zhang R
International journal of nanomedicine 2020;15:6279-6294
International journal of nanomedicine 2020;15:6279-6294
Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.
Jin J, Li X, Guo W, Li F, Huang J, Huang X, Pan J, Huang S, Ye W, Ling Q, Jin J
Oncology reports 2020 Jul;44(1):273-282
Oncology reports 2020 Jul;44(1):273-282
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
Jin J, Mao S, Li F, Li X, Huang X, Yu M, Guo W, Jin J
Medical oncology (Northwood, London, England) 2019 Aug 1;36(9):77
Medical oncology (Northwood, London, England) 2019 Aug 1;36(9):77
High PARP-1 expression predicts poor survival in acute myeloid leukemia and PARP-1 inhibitor and SAHA-bendamustine hybrid inhibitor combination treatment synergistically enhances anti-tumor effects.
Li X, Li C, Jin J, Wang J, Huang J, Ma Z, Huang X, He X, Zhou Y, Xu Y, Yu M, Huang S, Yan X, Li F, Pan J, Wang Y, Yu Y, Jin J
EBioMedicine 2018 Dec;38:47-56
EBioMedicine 2018 Dec;38:47-56
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Gao X, Wang W, Yang H, Wu L, He Z, Zhou S, Zhao H, Fu Z, Zhou F, Zhou Y
Oncotarget 2016 May 31;7(22):32543-53
Oncotarget 2016 May 31;7(22):32543-53
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Chk2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Chk2. This antibody recognizes human,mouse,rat antigen. The Chk2 antibody has been validated for the following applications: ELISA, WB analysis.