BS6152

antibody from Bioworld Technology, Inc
Targeting: GDF15 MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
Provider product page for BS6152
Western blot
Immunohistochemistry

Antibody data

Product number
BS6152 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GDF 15 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GDF-15.
Description
Growth differentiation factor 15 (GDF-15), also known as PDF, MIC-1, PLAB, NAG-1 or PTGF-ÉÇ, is a member of the transforming growth factor beta (TGF-beta) superfamily. Synthesized intracellularly, the protein is secreted as a dimer linked by disulfide bonds. Epithelial cells and macrophages are the sites of strongest GDF-15 expression, although it is widely expressed in adult tissue. In the brain, GDF-15 expression occurs in the choroid plexus, from which the protein is secreted into the cerebrospinal fluid. The gene for GDF-15 is responsive to p53 tumor suppressor protein, and in cultured cerebellar granule neurons GDF-15 can prevent cell death by the activation of Akt and inhibition of ERK. GDF-15 acts as a trophic factor for certain classes of neurons, promoting cell survival and differentiation. Overexpression of GDF-15 occurs in prostate cancer, and may be a means of diagnosis.
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GDF15 protein structure - BS6152 shown in red.