CABT-L2064

antibody from Creative Diagnostics

Targeting: ITGAD ADB2, CD11d

No application information provided.

Antibody Data

Product number

CABT-L2064

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human ITGaD Polyclonal Antibody

Antibody type

Polyclonal

Description

The alpha d integrin (CD11d) subunit is expressed as a heterodimer with beta 2 integrin (CD18). CD11d is expressed by a sub-population of macrophages, some CD8 positive T cells and by gamma/delta T cells in the splenic red pulp.Over expression of CD11d is noted in histiocytic disorders including Hemophagocytic sarcoma, described as a proliferative disorder specifically of CD11+ macrophages with macrophages demonstrating marked erythrocytic phagocytosis. Previously, canine histiocytic sarcoma were described as originating entirely from interstitial dendritic cells. Cells from animals with canine hepatosplenic T-cell lymphoma (HTSL) strongly express CD11d on malignant cells. Dogs normally demonstrate strong positivity for CD11d on large granular lymphocytes, macrophages and T cells in the splenic red pulp. CD11+ gamma/delta