Tissue expression
Cell line expression
Protein structure
MS4A2
Membrane spanning 4-domains A2APY, FCER1B, IGER, MS4A1
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Top validated antibodies |
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LSBio | LS-C197201 | Monoclonal |
WB
EL |
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Cusabio Biotech Co., Ltd | CSB-PA015013LA01HU | Polyclonal |
EL
ICC
IHC
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Biorbyt | orb422831 | Polyclonal |
EL
ICC
IHC
|
||
antibodies-online | ABIN395809 | Monoclonal |
WB
EL |
||
Novus Biologicals | H00002206-M02 | Monoclonal |
WB
EL |
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