66387-1-Ig

antibody from Proteintech Group

Targeting: GSDMD DF5L, FLJ12150, GSDMDC1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

66387-1-Ig

Provider

Proteintech Group

Product name

GSDMD antibody

Antibody type

Monoclonal

Description

GSDMD antibody (Cat. #66387-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IF, WB, ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2E6C7

Vial size

20ul, 150ul

References

Submitted references

Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity.

Lin L, Chen Y, Li Q, Xu G, Ding K, Ren L, Shi W, Wang Y, Li Z, Dai W, Wei Z, Yang Y, Bai Z, Xiao X
Journal of ethnopharmacology 2022 Mar 1;285:114796

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Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation.

Xu L, Lin L, Lu X, Xiao P, Liu R, Wu M, Jin M, Zhang A
Emerging microbes & infections 2021 Dec;10(1):1309-1319

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An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS).

Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A
PLoS pathogens 2019 Jun;15(6):e1007795

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Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells.

Ojeda DS, Grasso D, Urquiza J, Till A, Vaccaro MI, Quarleri J
Frontiers in immunology 2018;9:2633