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- Antigen structure
- References [35]
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- Product number
- 10594-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10594-1-AP, RRID:AB_2252194
- Product name
- PEX14 antibody
- Antibody type
- Polyclonal
- Description
- PEX14 antibody (Cat. #10594-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proteomic Identification of Coxiella burnetii Effector Proteins Targeted to the Host Cell Mitochondria During Infection.
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells.
HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4+ T cell death.
Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor.
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Establishment and analysis of conditional Rab1- and Rab5-knockout cells using the auxin-inducible degron system.
An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.
Drp1 Tubulates the ER in a GTPase-Independent Manner.
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division.
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.
F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes.
Super-resolution imaging reveals the sub-diffraction phenotype of Zellweger Syndrome ghosts and wild-type peroxisomes.
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Isolation of Peroxisomes from Mouse Brain Using a Continuous Nycodenz Gradient: A Comparison to the Isolation of Liver and Kidney Peroxisomes.
Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy.
Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics.
The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code.
Spectrum of PEX1 and PEX6 variants in Heimler syndrome.
A Dendritic Golgi Satellite between ERGIC and Retromer.
Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins.
Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals.
Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.
Peroxisomes are juxtaposed to strategic sites on mitochondria.
Functional analysis of PEX13 mutation in a Zellweger syndrome spectrum patient reveals novel homooligomerization of PEX13 and its role in human peroxisome biogenesis.
Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission.
Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice.
Loss of ceramide synthase 3 causes lethal skin barrier disruption.
Lymphoblastoid cell lines for diagnosis of peroxisome biogenesis disorders.
The unusual extended C-terminal helix of the peroxisomal α/β-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization.
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
Typical cMRI pattern as diagnostic clue for D-bifunctional protein deficiency without apparent biochemical abnormalities in plasma.
Fielden LF, Scott NE, Palmer CS, Khoo CA, Newton HJ, Stojanovski D
Molecular & cellular proteomics : MCP 2021;20:100005
Molecular & cellular proteomics : MCP 2021;20:100005
Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells.
Sargsyan Y, Bickmeyer U, Gibhardt CS, Streckfuss-Bömeke K, Bogeski I, Thoms S
Life science alliance 2021 Sep;4(9)
Life science alliance 2021 Sep;4(9)
HIV-1 Env induces pexophagy and an oxidative stress leading to uninfected CD4+ T cell death.
Daussy CF, Galais M, Pradel B, Robert-Hebmann V, Sagnier S, Pattingre S, Biard-Piechaczyk M, Espert L
Autophagy 2021 Sep;17(9):2465-2474
Autophagy 2021 Sep;17(9):2465-2474
Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor.
Uesugi R, Ishii S, Matsuura A, Itakura E
The Journal of biological chemistry 2021 Nov;297(5):101279
The Journal of biological chemistry 2021 Nov;297(5):101279
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.
Bennett CF, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P
Nature chemical biology 2021 Jun;17(6):703-710
Nature chemical biology 2021 Jun;17(6):703-710
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling.
de la Calle Arregui C, Plata-Gómez AB, Deleyto-Seldas N, García F, Ortega-Molina A, Abril-Garrido J, Rodriguez E, Nemazanyy I, Tribouillard L, de Martino A, Caleiras E, Campos-Olivas R, Mulero F, Laplante M, Muñoz J, Pende M, Sabio G, Sabatini DM, Efeyan A
Nature communications 2021 Jun 16;12(1):3660
Nature communications 2021 Jun 16;12(1):3660
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Establishment and analysis of conditional Rab1- and Rab5-knockout cells using the auxin-inducible degron system.
Hatoyama Y, Homma Y, Hiragi S, Fukuda M
Journal of cell science 2021 Dec 15;134(24)
Journal of cell science 2021 Dec 15;134(24)
An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.
Coukos R, Yao D, Sanchez MI, Strand ET, Olive ME, Udeshi ND, Weissman JS, Carr SA, Bassik MC, Ting AY
eLife 2021 Aug 20;10
eLife 2021 Aug 20;10
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.
Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A
Cell 2020 Oct 1;183(1):94-109.e23
Cell 2020 Oct 1;183(1):94-109.e23
Drp1 Tubulates the ER in a GTPase-Independent Manner.
Adachi Y, Kato T, Yamada T, Murata D, Arai K, Stahelin RV, Chan DC, Iijima M, Sesaki H
Molecular cell 2020 Nov 19;80(4):621-632.e6
Molecular cell 2020 Nov 19;80(4):621-632.e6
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division.
Nagashima S, Tábara LC, Tilokani L, Paupe V, Anand H, Pogson JH, Zunino R, McBride HM, Prudent J
Science (New York, N.Y.) 2020 Mar 20;367(6484):1366-1371
Science (New York, N.Y.) 2020 Mar 20;367(6484):1366-1371
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu SN, Ochiai H, Saito Y, Yamamoto T, Matsuura S
The EMBO journal 2020 Jun 17;39(12):e103499
The EMBO journal 2020 Jun 17;39(12):e103499
A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.
Wang P, Luo R, Zhang M, Wang Y, Song T, Tao T, Li Z, Jin L, Zheng H, Chen W, Zhao M, Zheng Y, Qin J
Cell death & disease 2020 Dec 8;11(12):1042
Cell death & disease 2020 Dec 8;11(12):1042
F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes.
van Bommel B, Konietzny A, Kobler O, Bär J, Mikhaylova M
The EMBO journal 2019 Aug 1;38(15):e101183
The EMBO journal 2019 Aug 1;38(15):e101183
Super-resolution imaging reveals the sub-diffraction phenotype of Zellweger Syndrome ghosts and wild-type peroxisomes.
Soliman K, Göttfert F, Rosewich H, Thoms S, Gärtner J
Scientific reports 2018 May 17;8(1):7809
Scientific reports 2018 May 17;8(1):7809
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, Zhao M, He H, Zhang Y, Rao Q, Zhao D, Wang Y, Fan L, Li P, Liu Y, Liu F, Zhang F, Ye J, Yan Q, Guo S, Wang Z
Scientific reports 2018 Jul 2;8(1):9972
Scientific reports 2018 Jul 2;8(1):9972
Isolation of Peroxisomes from Mouse Brain Using a Continuous Nycodenz Gradient: A Comparison to the Isolation of Liver and Kidney Peroxisomes.
Schönenberger MJ, Kovacs WJ
Methods in molecular biology (Clifton, N.J.) 2017;1595:13-26
Methods in molecular biology (Clifton, N.J.) 2017;1595:13-26
Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy.
Hofhuis J, Bersch K, Büssenschütt R, Drzymalski M, Liebetanz D, Nikolaev VO, Wagner S, Maier LS, Gärtner J, Klinge L, Thoms S
Journal of cell science 2017 Mar 1;130(5):841-852
Journal of cell science 2017 Mar 1;130(5):841-852
Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics.
Cherok E, Xu S, Li S, Das S, Meltzer WA, Zalzman M, Wang C, Karbowski M
Molecular biology of the cell 2017 Feb 1;28(3):396-410
Molecular biology of the cell 2017 Feb 1;28(3):396-410
The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code.
Hofhuis J, Schueren F, Nötzel C, Lingner T, Gärtner J, Jahn O, Thoms S
Open biology 2016 Nov;6(11)
Open biology 2016 Nov;6(11)
Spectrum of PEX1 and PEX6 variants in Heimler syndrome.
Smith CE, Poulter JA, Levin AV, Capasso JE, Price S, Ben-Yosef T, Sharony R, Newman WG, Shore RC, Brookes SJ, Mighell AJ, Inglehearn CF
European journal of human genetics : EJHG 2016 Nov;24(11):1565-1571
European journal of human genetics : EJHG 2016 Nov;24(11):1565-1571
A Dendritic Golgi Satellite between ERGIC and Retromer.
Mikhaylova M, Bera S, Kobler O, Frischknecht R, Kreutz MR
Cell reports 2016 Jan 12;14(2):189-99
Cell reports 2016 Jan 12;14(2):189-99
Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins.
Buentzel J, Vilardi F, Lotz-Havla A, Gärtner J, Thoms S
Scientific reports 2015 Dec 2;5:17420
Scientific reports 2015 Dec 2;5:17420
Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals.
Schueren F, Lingner T, George R, Hofhuis J, Dickel C, Gärtner J, Thoms S
eLife 2014 Sep 23;3:e03640
eLife 2014 Sep 23;3:e03640
Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.
Walter KM, Schönenberger MJ, Trötzmüller M, Horn M, Elsässer HP, Moser AB, Lucas MS, Schwarz T, Gerber PA, Faust PL, Moch H, Köfeler HC, Krek W, Kovacs WJ
Cell metabolism 2014 Nov 4;20(5):882-897
Cell metabolism 2014 Nov 4;20(5):882-897
Peroxisomes are juxtaposed to strategic sites on mitochondria.
Cohen Y, Klug YA, Dimitrov L, Erez Z, Chuartzman SG, Elinger D, Yofe I, Soliman K, Gärtner J, Thoms S, Schekman R, Elbaz-Alon Y, Zalckvar E, Schuldiner M
Molecular bioSystems 2014 Jul;10(7):1742-8
Molecular bioSystems 2014 Jul;10(7):1742-8
Functional analysis of PEX13 mutation in a Zellweger syndrome spectrum patient reveals novel homooligomerization of PEX13 and its role in human peroxisome biogenesis.
Krause C, Rosewich H, Woehler A, Gärtner J
Human molecular genetics 2013 Oct 1;22(19):3844-57
Human molecular genetics 2013 Oct 1;22(19):3844-57
Charcot-Marie-Tooth disease-associated mutants of GDAP1 dissociate its roles in peroxisomal and mitochondrial fission.
Huber N, Guimaraes S, Schrader M, Suter U, Niemann A
EMBO reports 2013 Jun;14(6):545-52
EMBO reports 2013 Jun;14(6):545-52
Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice.
Kovacs WJ, Charles KN, Walter KM, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL
Biochimica et biophysica acta 2012 Jun;1821(6):895-907
Biochimica et biophysica acta 2012 Jun;1821(6):895-907
Loss of ceramide synthase 3 causes lethal skin barrier disruption.
Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Gröne HJ, Sandhoff R
Human molecular genetics 2012 Feb 1;21(3):586-608
Human molecular genetics 2012 Feb 1;21(3):586-608
Lymphoblastoid cell lines for diagnosis of peroxisome biogenesis disorders.
Grønborg S, Krätzner R, Rosewich H, Gärtner J
JIMD reports 2011;1:29-36
JIMD reports 2011;1:29-36
The unusual extended C-terminal helix of the peroxisomal α/β-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization.
Thoms S, Hofhuis J, Thöing C, Gärtner J, Niemann HH
Journal of structural biology 2011 Sep;175(3):362-71
Journal of structural biology 2011 Sep;175(3):362-71
A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity.
Kassmann CM, Quintes S, Rietdorf J, Möbius W, Sereda MW, Nientiedt T, Saher G, Baes M, Nave KA
FEBS letters 2011 Jul 21;585(14):2205-11
FEBS letters 2011 Jul 21;585(14):2205-11
Typical cMRI pattern as diagnostic clue for D-bifunctional protein deficiency without apparent biochemical abnormalities in plasma.
Grønborg S, Krätzner R, Spiegler J, Ferdinandusse S, Wanders RJ, Waterham HR, Gärtner J
American journal of medical genetics. Part A 2010 Nov;152A(11):2845-9
American journal of medical genetics. Part A 2010 Nov;152A(11):2845-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 10594-1-AP(PEX14 antibody) at dilution of 1:500
- Sample type
- tissue
