55084-1-AP

antibody from Proteintech Group

Targeting: DRD2

Provider product page for 55084-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
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Validations
Western blot [1]

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Product number: 55084-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55084-1-AP, RRID:AB_10859941
Product name: DRD2 antibody
Antibody type: Polyclonal
Description: KD/KO validated DRD2 antibody (Cat. #55084-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

DRD2 protein structure - 55084-1-AP shown in red.

Submitted references Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis.

Bénac N, Ezequiel Saraceno G, Butler C, Kuga N, Nishimura Y, Yokoi T, Su P, Sasaki T, Petit-Pedrol M, Galland R, Studer V, Liu F, Ikegaya Y, Sibarita JB, Groc L
Nature communications 2024 Jan 2;15(1):27

Intranasal Delivery of Near-Infrared and Magnetic Dual-Response Nanospheres to Rapidly Produce Antidepressant-Like and Cognitive Enhancement Effects.

Hu J, Lian Z, Weng Z, Xu Z, Gao J, Liu Y, Luo T, Wang X
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(31):e2405547

Dopamine D2-receptor neurons in nucleus accumbens regulate sevoflurane anesthesia in mice.

Niu L, Hao M, Wang Y, Wu K, Yuan C, Zhang Y, Zhang J, Liang X, Zhang Y
Frontiers in molecular neuroscience 2023;16:1287160

Neuropathological features of levodopa-responsive parkinsonism in multiple system atrophy: an autopsy case report and comparative neuropathological study.

Tamura M, Takeda T, Kitayama Y, Suichi T, Shibuya K, Harada-Kagitani S, Kishimoto T, Kuwabara S, Hirano S
Frontiers in neurology 2023;14:1293732

Network pharmacology, molecular docking, and experimental validation to explore the potential mechanism of Long Mu Qing Xin mixture for the treatment of attention deficit hyperactivity disorder.

Li X, Xiao Z, Pu W, Jiang Z, Wang S, Zhang Y
Frontiers in pharmacology 2023;14:1144907

Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.

Kambey PA, Liu WY, Wu J, Tang C, Buberwa W, Saro A, Nyalali AMK, Gao D
CNS neuroscience & therapeutics 2023 Oct;29(10):2925-2939

Dopaminergic Projections from the Hypothalamic A11 Nucleus to the Spinal Trigeminal Nucleus Are Involved in Bidirectional Migraine Modulation.

Li C, Li Y, Zhang W, Ma Z, Xiao S, Xie W, Miao S, Li B, Lu G, Liu Y, Bai W, Yu S
International journal of molecular sciences 2023 Nov 28;24(23)

Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra.

Burkert N, Roy S, Häusler M, Wuttke D, Müller S, Wiemer J, Hollmann H, Oldrati M, Ramirez-Franco J, Benkert J, Fauler M, Duda J, Goaillard JM, Pötschke C, Münchmeyer M, Parlato R, Liss B
Communications biology 2023 Nov 10;6(1):1146

5-HT4 Receptor is Protective for MPTP-induced Parkinson's Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota.

Cui C, Shi Y, Hong H, Zhou Y, Qiao C, Zhao L, Jia X, Zhao W, Shen Y
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2023 Dec;18(4):610-627

Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.

Gao SQ, Chen JQ, Zhou HY, Luo L, Zhang BY, Li MT, He HY, Chen C, Guo Y
iScience 2023 Apr 21;26(4):106488

Knockout of Dopamine D3 Receptor Gene Blocked Methamphetamine-Induced Distinct Changes of Dopaminergic and Glutamatergic Synapse in the Nucleus Accumbens Shell of Mice.

Wang S, Li M, Su L, Wang Y, Ma D, Wang H, Zhu J, Chen T
Frontiers in cellular neuroscience 2022;16:893190

Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms.

Cao YL, -Zhu L, Zhang H, Meng JH, Wu HJ, Wang X, Wu JH, Zou JL, Fang MS, An J, Chen YG
Frontiers in pharmacology 2022;13:888522

Electroacupuncture Alleviates Anxiety-Like Behaviors Induced by Chronic Neuropathic Pain via Regulating Different Dopamine Receptors of the Basolateral Amygdala.

Wu M, Chen Y, Shen Z, Zhu Y, Xiao S, Zhu X, Wu Z, Liu J, Xu C, Yao P, Xu W, Liang Y, Liu B, Du J, He X, Liu B, Jin X, Fang J, Shao X
Molecular neurobiology 2022 Sep;59(9):5299-5311

Biochemical Neuroadaptations in the Rat Striatal Dopaminergic System after Prolonged Exposure to Methamphetamine Self-Administration.

Jayanthi S, Ladenheim B, Sullivan P, McCoy MT, Krasnova IN, Goldstein DS, Cadet JL
International journal of molecular sciences 2022 Sep 3;23(17)

ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.

Han Q, Yan X, Ye Y, Han L, Ma X, Wang T, Cao D, Zhang WJ
Endocrinology 2022 Oct 23;163(12)

Mechanistic analysis of erectile dysfunction in a depression rat model.

Hong ZM, Chen ZL, Feng JL, Wang SJ, Qiu JF, Zeng YL, Wang Q, Wang JS
The Journal of international medical research 2022 May;50(5):3000605221100334

Dopamine D2 receptors in the nucleus accumbens modulate erectile function in a rat model of nonorganic erectile dysfunction.

Chen G, Yu D, Wu Y, Dong J, Hu L, Feng N
Andrology 2022 May;10(4):808-817

Xiaoyao San ameliorates high-fat diet-induced anxiety and depression via regulating gut microbiota in mice.

Yang Y, Zhong Z, Wang B, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113902

Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine.

Zhang W, Lei M, Wen Q, Zhang D, Qin G, Zhou J, Chen L
The journal of headache and pain 2022 Aug 10;23(1):98

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.

Wang S, Wang A, Zhang Y, Zhu K, Wang X, Chen Y, Wu J
BMC endocrine disorders 2021 Nov 23;21(1):235

Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.

Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380

ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.

Huang Y, Huang J, Zhou QX, Yang CX, Yang CP, Mei WY, Zhang L, Zhang Q, Hu L, Hu YQ, Song NN, Wu SX, Xu L, Ding YQ
Molecular psychiatry 2021 Jun;26(6):2514-2532

Total barley maiya alkaloids inhibit prolactin secretion by acting on dopamine D2 receptor and protein kinase A targets.

Gong X, Tao J, Wang Y, Wu J, An J, Meng J, Wang X, Chen Y, Zou J
Journal of ethnopharmacology 2021 Jun 12;273:113994

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.

Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K
Biomedicines 2021 Jan 8;9(1)

A high-throughput screen identifies inhibitors of lung cancer stem cells.

She X, Gao Y, Zhao Y, Yin Y, Dong Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Aug;140:111748

Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors.

Loehr AR, Pierpont TM, Gelsleichter E, Galang AMD, Fernandez IR, Moore ES, Guo MZ, Miller AD, Weiss RS
Cancers 2021 Apr 23;13(9)

The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.

Ren L, Liu W, Wang C, Yang Y, Huang X, Wang C, Li Y
Journal of ethnopharmacology 2020 May 23;254:112572

Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia in rats by attenuating impairment of the dopamine D2 receptor and TGF-β1 signaling pathways in the hypothalamus and pituitary.

Huang X, Ren L, Hou L, Fan H, Wang C, Wang C, Li Y
Journal of ethnopharmacology 2020 Jul 15;257:112862

Targeting Dopamine Receptor D2 by Imipridone Suppresses Uterine Serous Cancer Malignant Phenotype.

Hu W, Zhang L, Ferri-Borgogno S, Kwan SY, Lewis KE, Cun HT, Yeung TL, Soliman PT, Tarapore RS, Allen JE, Guan X, Lu KH, Mok SC, Au-Yeung CL
Cancers 2020 Aug 27;12(9)

Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction.

Chen G, Chen J, Yang B, Yu W, Chen Y, Dai Y
Andrologia 2019 Feb;51(1):e13160

Development of a peptide targeting dopamine transporter to improve ADHD-like deficits.

Lai TKY, Su P, Zhang H, Liu F
Molecular brain 2018 Nov 9;11(1):66

Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.

Srivastava P, Dhuriya YK, Gupta R, Shukla RK, Yadav RS, Dwivedi HN, Pant AB, Khanna VK
Molecular neurobiology 2018 Jan;55(1):445-461

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.

Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R
Cell 2015 Jan 15;160(1-2):62-73

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The DRD2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human DRD2. This antibody recognizes human, mouse, rat antigen. The DRD2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 55084-1-AP.pdf

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