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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [47]
- Comments [0]
- Validations
- Western blot [2]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- ABIN152489 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Growth Associated Protein 43 (GAP43) antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian, Porcine, Simian
- Host
- Rabbit
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references miR-3074-5p Promotes the Apoptosis but Inhibits the Invasiveness of Human Extravillous Trophoblast-Derived HTR8/SVneo Cells In Vitro.
Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation.
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1.
Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment.
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury.
Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury.
Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains.
Macromolecular markers in normal human retina and applications to human retinal disease.
Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration.
Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons.
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway.
Cigarette Smoke Delays Regeneration of the Olfactory Epithelium in Mice.
Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins.
The relationship between changes in the expression of growth associated protein-43 and functional recovery of the injured inferior alveolar nerve following transection without repair in adult rats.
Neuromatous regeneration as a nerve response after catheter-based renal denervation therapy in a large animal model: immunohistochemical study.
Immunohistochemical and lectin histochemical studies on the developing olfactory organs of fetal camel.
Transient appearance of the epithelial invagination in the olfactory pit of chick embryos.
The vomeronasal organ of Lemur catta.
Shotgun proteomics reveals possible mechanisms for cognitive impairment in Mucopolysaccharidosis I mice.
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq.
Therapeutic potential of induced neural stem cells for spinal cord injury.
The morphological and molecular changes of brain cells exposed to direct current electric field stimulation.
A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.
The vomeronasal complex of nocturnal strepsirhines and implications for the ancestral condition in primates.
Critical role of GFRα1 in the development and function of the main olfactory system.
IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.
Reproducible mouse sciatic nerve crush and subsequent assessment of regeneration by whole mount muscle analysis.
Creatine transporter immunolocalization in aged human and detached retinas.
Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43.
Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium.
In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.
Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.
Fas-associated factor 1 as a regulator of olfactory axon guidance.
Composition of the migratory mass during development of the olfactory nerve.
Wnt/Frizzled family members mediate olfactory sensory neuron axon extension.
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system.
Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration.
Tumorigenic properties of neurofibromin-deficient Schwann cells in culture and as syngrafts in Nf1 knockout mice.
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.
Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.
Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan.
Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts.
Axonal regeneration into acellular nerve grafts is enhanced by degradation of chondroitin sulfate proteoglycan.
MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve.
GAP-43: an intrinsic determinant of neuronal development and plasticity.
The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury.
Gu Y, Shi Y, Yang Q, Gu WW, He YP, Zheng HJ, Zhang X, Wang JM, Wang J
Reproductive sciences (Thousand Oaks, Calif.) 2018 May;25(5):690-699
Reproductive sciences (Thousand Oaks, Calif.) 2018 May;25(5):690-699
Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation.
Kosi N, Alić I, Salamon I, Mitrečić D
Neuroscience letters 2018 Feb 14;666:111-119
Neuroscience letters 2018 Feb 14;666:111-119
Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1.
Pal-Ghosh S, Tadvalkar G, Stepp MA
Investigative ophthalmology & visual science 2017 Oct 1;58(12):4959-4975
Investigative ophthalmology & visual science 2017 Oct 1;58(12):4959-4975
Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment.
Lemons K, Fu Z, Aoudé I, Ogura T, Sun J, Chang J, Mbonu K, Matsumoto I, Arakawa H, Lin W
eNeuro 2017 May-Jun;4(3)
eNeuro 2017 May-Jun;4(3)
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury.
Lopes CDF, Gonçalves NP, Gomes CP, Saraiva MJ, Pêgo AP
Biomaterials 2017 Mar;121:83-96
Biomaterials 2017 Mar;121:83-96
Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury.
Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, Yoshizaki S, Harimaya K, Nakashima Y, Okada S
Nature medicine 2017 Jul;23(7):818-828
Nature medicine 2017 Jul;23(7):818-828
Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains.
Akins MR, Berk-Rauch HE, Kwan KY, Mitchell ME, Shepard KA, Korsak LI, Stackpole EE, Warner-Schmidt JL, Sestan N, Cameron HA, Fallon JR
Human molecular genetics 2017 Jan 1;26(1):192-209
Human molecular genetics 2017 Jan 1;26(1):192-209
Macromolecular markers in normal human retina and applications to human retinal disease.
de Souza CF, Nivison-Smith L, Christie DL, Polkinghorne P, McGhee C, Kalloniatis M, Acosta ML
Experimental eye research 2016 Sep;150:135-48
Experimental eye research 2016 Sep;150:135-48
Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration.
Ku JM, Park K, Lee JH, Cho KJ, Nam YJ, Jeong DY, Kim YH, Kwon S, Park JY, Yang J, Nam TG, Yoon SH, Ahn S, Choi Y
Journal of medicinal chemistry 2016 May 26;59(10):4676-87
Journal of medicinal chemistry 2016 May 26;59(10):4676-87
Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons.
Nakano H, Iida Y, Suzuki M, Aoki M, Umemura M, Takahashi S, Takahashi Y
Cell and tissue research 2016 Mar;363(3):621-33
Cell and tissue research 2016 Mar;363(3):621-33
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
Smolek T, Madari A, Farbakova J, Kandrac O, Jadhav S, Cente M, Brezovakova V, Novak M, Zilka N
The Journal of comparative neurology 2016 Mar 1;524(4):874-95
The Journal of comparative neurology 2016 Mar 1;524(4):874-95
APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway.
Cheng N, Jiao S, Gumaste A, Bai L, Belluscio L
eNeuro 2016 Jul-Aug;3(4)
eNeuro 2016 Jul-Aug;3(4)
Cigarette Smoke Delays Regeneration of the Olfactory Epithelium in Mice.
Ueha R, Ueha S, Sakamoto T, Kanaya K, Suzukawa K, Nishijima H, Kikuta S, Kondo K, Matsushima K, Yamasoba T
Neurotoxicity research 2016 Aug;30(2):213-24
Neurotoxicity research 2016 Aug;30(2):213-24
Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins.
Janmaat CJ, de Rooij KE, Locher H, de Groot SC, de Groot JC, Frijns JH, Huisman MA
PloS one 2015;10(12):e0145235
PloS one 2015;10(12):e0145235
The relationship between changes in the expression of growth associated protein-43 and functional recovery of the injured inferior alveolar nerve following transection without repair in adult rats.
Ceber M, Sener U, Mihmanli A, Kilic U, Topcu B, Karakas M
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2015 Nov;43(9):1906-13
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 2015 Nov;43(9):1906-13
Neuromatous regeneration as a nerve response after catheter-based renal denervation therapy in a large animal model: immunohistochemical study.
Rousselle SD, Brants IK, Sakaoka A, Hubbard B, Jackson ND, Wicks JR, Dillon KN, Naiche LA, Hart R, Garza JA, Tellez A
Circulation. Cardiovascular interventions 2015 May;8(5)
Circulation. Cardiovascular interventions 2015 May;8(5)
Immunohistochemical and lectin histochemical studies on the developing olfactory organs of fetal camel.
Ibrahim D, Taniguchi K, Yamamoto Y, Taniguchi K, Nakamuta N
Microscopy research and technique 2015 Jul;78(7):613-9
Microscopy research and technique 2015 Jul;78(7):613-9
Transient appearance of the epithelial invagination in the olfactory pit of chick embryos.
Nakamuta S, Nakamuta N, Yamamoto Y, Onodera N, Araki I
The Journal of veterinary medical science 2015 Jan;77(1):89-93
The Journal of veterinary medical science 2015 Jan;77(1):89-93
The vomeronasal organ of Lemur catta.
Smith TD, Muchlinski MN, Bhatnagar KP, Durham EL, Bonar CJ, Burrows AM
American journal of primatology 2015 Feb;77(2):229-38
American journal of primatology 2015 Feb;77(2):229-38
Shotgun proteomics reveals possible mechanisms for cognitive impairment in Mucopolysaccharidosis I mice.
Baldo G, Lorenzini DM, Santos DS, Mayer FQ, Vitry S, Bigou S, Heard JM, Matte U, Giugliani R
Molecular genetics and metabolism 2015 Feb;114(2):138-45
Molecular genetics and metabolism 2015 Feb;114(2):138-45
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq.
Zechel S, Zajac P, Lönnerberg P, Ibáñez CF, Linnarsson S
Genome biology 2014;15(10):486
Genome biology 2014;15(10):486
Therapeutic potential of induced neural stem cells for spinal cord injury.
Hong JY, Lee SH, Lee SC, Kim JW, Kim KP, Kim SM, Tapia N, Lim KT, Kim J, Ahn HS, Ko K, Shin CY, Lee HT, Schöler HR, Hyun JK, Han DW
The Journal of biological chemistry 2014 Nov 21;289(47):32512-25
The Journal of biological chemistry 2014 Nov 21;289(47):32512-25
The morphological and molecular changes of brain cells exposed to direct current electric field stimulation.
Pelletier SJ, Lagacé M, St-Amour I, Arsenault D, Cisbani G, Chabrat A, Fecteau S, Lévesque M, Cicchetti F
The international journal of neuropsychopharmacology 2014 Dec 7;18(5)
The international journal of neuropsychopharmacology 2014 Dec 7;18(5)
A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.
Ambjørn M, Dubreuil V, Miozzo F, Nigon F, Møller B, Issazadeh-Navikas S, Berg J, Lees M, Sap J
PloS one 2013;8(6):e65371
PloS one 2013;8(6):e65371
The vomeronasal complex of nocturnal strepsirhines and implications for the ancestral condition in primates.
Garrett EC, Dennis JC, Bhatnagar KP, Durham EL, Burrows AM, Bonar CJ, Steckler NK, Morrison EE, Smith TD
Anatomical record (Hoboken, N.J. : 2007) 2013 Dec;296(12):1881-94
Anatomical record (Hoboken, N.J. : 2007) 2013 Dec;296(12):1881-94
Critical role of GFRα1 in the development and function of the main olfactory system.
Marks C, Belluscio L, Ibáñez CF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 28;32(48):17306-20
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 28;32(48):17306-20
IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.
Ray A, Treloar HB
Molecular and cellular neurosciences 2012 Jul;50(3-4):238-49
Molecular and cellular neurosciences 2012 Jul;50(3-4):238-49
Reproducible mouse sciatic nerve crush and subsequent assessment of regeneration by whole mount muscle analysis.
Bauder AR, Ferguson TA
Journal of visualized experiments : JoVE 2012 Feb 22;(60)
Journal of visualized experiments : JoVE 2012 Feb 22;(60)
Creatine transporter immunolocalization in aged human and detached retinas.
de Souza CF, Kalloniatis M, Christie DL, Polkinghorne PJ, McGhee CN, Acosta ML
Investigative ophthalmology & visual science 2012 Apr 18;53(4):1936-45
Investigative ophthalmology & visual science 2012 Apr 18;53(4):1936-45
Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43.
Grasselli G, Mandolesi G, Strata P, Cesare P
PloS one 2011;6(6):e20791
PloS one 2011;6(6):e20791
Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium.
Pluznick JL, Rodriguez-Gil DJ, Hull M, Mistry K, Gattone V, Johnson CA, Weatherbee S, Greer CA, Caplan MJ
PloS one 2011;6(5):e19694
PloS one 2011;6(5):e19694
In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.
Cheng N, Cai H, Belluscio L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 28;31(39):13699-704
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 28;31(39):13699-704
Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.
Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T
Journal of cellular biochemistry 2011 Nov;112(11):3449-58
Journal of cellular biochemistry 2011 Nov;112(11):3449-58
Fas-associated factor 1 as a regulator of olfactory axon guidance.
Cheng K, Bai L, Belluscio L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Aug 17;31(33):11905-13
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Aug 17;31(33):11905-13
Composition of the migratory mass during development of the olfactory nerve.
Miller AM, Treloar HB, Greer CA
The Journal of comparative neurology 2010 Dec 15;518(24):4825-41
The Journal of comparative neurology 2010 Dec 15;518(24):4825-41
Wnt/Frizzled family members mediate olfactory sensory neuron axon extension.
Rodriguez-Gil DJ, Greer CA
The Journal of comparative neurology 2008 Nov 20;511(3):301-17
The Journal of comparative neurology 2008 Nov 20;511(3):301-17
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system.
Osterfield M, Egelund R, Young LM, Flanagan JG
Development (Cambridge, England) 2008 Mar;135(6):1189-99
Development (Cambridge, England) 2008 Mar;135(6):1189-99
Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration.
Graham JB, Neubauer D, Xue QS, Muir D
Experimental neurology 2007 Jan;203(1):185-95
Experimental neurology 2007 Jan;203(1):185-95
Tumorigenic properties of neurofibromin-deficient Schwann cells in culture and as syngrafts in Nf1 knockout mice.
Wu M, Wallace MR, Muir D
Journal of neuroscience research 2005 Nov 1;82(3):357-67
Journal of neuroscience research 2005 Nov 1;82(3):357-67
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.
Teo JL, Ma H, Nguyen C, Lam C, Kahn M
Proceedings of the National Academy of Sciences of the United States of America 2005 Aug 23;102(34):12171-6
Proceedings of the National Academy of Sciences of the United States of America 2005 Aug 23;102(34):12171-6
Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.
Berwanger B, Hartmann O, Bergmann E, Bernard S, Nielsen D, Krause M, Kartal A, Flynn D, Wiedemeyer R, Schwab M, Schäfer H, Christiansen H, Eilers M
Cancer cell 2002 Nov;2(5):377-86
Cancer cell 2002 Nov;2(5):377-86
Regeneration of axons after nerve transection repair is enhanced by degradation of chondroitin sulfate proteoglycan.
Zuo J, Neubauer D, Graham J, Krekoski CA, Ferguson TA, Muir D
Experimental neurology 2002 Jul;176(1):221-8
Experimental neurology 2002 Jul;176(1):221-8
Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts.
Krekoski CA, Neubauer D, Graham JB, Muir D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Dec 1;22(23):10408-15
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Dec 1;22(23):10408-15
Axonal regeneration into acellular nerve grafts is enhanced by degradation of chondroitin sulfate proteoglycan.
Krekoski CA, Neubauer D, Zuo J, Muir D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Aug 15;21(16):6206-13
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001 Aug 15;21(16):6206-13
MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve.
Ferguson TA, Muir D
Molecular and cellular neurosciences 2000 Aug;16(2):157-67
Molecular and cellular neurosciences 2000 Aug;16(2):157-67
GAP-43: an intrinsic determinant of neuronal development and plasticity.
Benowitz LI, Routtenberg A
Trends in neurosciences 1997 Feb;20(2):84-91
Trends in neurosciences 1997 Feb;20(2):84-91
The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury.
Woolf CJ, Reynolds ML, Molander C, O'Brien C, Lindsay RM, Benowitz LI
Neuroscience 1990;34(2):465-78
Neuroscience 1990;34(2):465-78
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunofluorescence of GAP-43 (green), a molecular marker of neurite outgrowth, demonstrates intense staining in overexpressing wild-type PS-1 (E) PC-12 cells. (Teo, et al, 2005)
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
