BS8373

antibody from Bioworld Technology, Inc
Targeting: PUF60 FIR, RoBPI, SIAHBP1
Provider product page for BS8373
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8373 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PUF60 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PUF60.
Description
Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-myc. The binding of FBP (FUSE-binding protein) to FUSE is necessary for c-myc expression. The FBP interacting repressor, FIR, binds to the central DNA-binding domain of FBP and can serve as an overriding negative regulator of c-myc promoter activity. FIR interacts with the TFIIH complex, which is a multifunctional, multisubunit RNA polymerase II transcription factor that interacts with several DNA-binding transactivators. FIR blocks activator-dependent, but not basal transcription through TFIIH. FIR shares identity with seven in absentia (siah) binding protein 1. FIR is expressed in spleen, thymus, prostate, small intestine, colon, and peripheral blood leukocytes, and with relatively higher levels of expression in testis and ovary .
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PUF60 protein structure - BS8373 shown in red.