AGBL5

This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a ""dual-functional"" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]

Description

ATP/GTP binding protein like 5

Tissue specificity

Group enriched (parathyroid gland, testis)

Subcell location

Microtubules, Cytokinetic bridge, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins

Chromosome

2 (27042364 - 27070622)

Ensembl ID

ENSG00000084693  (ver. 103.38)

Orthologs

Mouse Agbl5: ENSMUSG00000029165

UniProt

Q8NDL9

neXtProt

NX_Q8NDL9

Human splice variants
Mouse splice variants

Protein structure