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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Immunohistochemistry [1]
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- Product number
- AF570 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Endostatin Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse Endostatin in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human Endostatin is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop.
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer.
Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model.
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
Öhlund D, Franklin O, Lundberg E, Lundin C, Sund M
BMC cancer 2013 Mar 26;13:154
BMC cancer 2013 Mar 26;13:154
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Fukuda H, Mochizuki S, Abe H, Okano HJ, Hara-Miyauchi C, Okano H, Yamaguchi N, Nakayama M, D'Armiento J, Okada Y
British journal of cancer 2011 Nov 8;105(10):1615-24
British journal of cancer 2011 Nov 8;105(10):1615-24
Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer.
Lan KL, Ou-Yang F, Yen SH, Shih HL, Lan KH
Clinical & experimental metastasis 2010 May;27(5):307-18
Clinical & experimental metastasis 2010 May;27(5):307-18
Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model.
Tanabe K, Maeshima Y, Ichinose K, Kitayama H, Takazawa Y, Hirokoshi K, Kinomura M, Sugiyama H, Makino H
Kidney international 2007 Feb;71(3):227-38
Kidney international 2007 Feb;71(3):227-38
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM
The American journal of pathology 2006 Nov;169(5):1767-83
The American journal of pathology 2006 Nov;169(5):1767-83
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
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- Experimental details
- Endostatin in Mouse Intestine. Endostatin was detected in perfusion fixed frozen sections of mouse intestine using Goat Anti-Mouse Endostatin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF570) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to lacteals. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
