Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8133 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SIVA1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human SIVA1.
- Description
- A cytoplasmic domain of approximately 80 amino acids was identified in the apoptosis-mediating receptors TNFR1 and Fas. This region was determined to be necessary for the transduction of the apoptotic signal and was designated the ¡ùdeath domain¡ì. Other death domain-containing, but otherwise structurally unrelated, proteins have been identified on the basis of their ability to associate with the cytoplasmic domains of TNFR1 or FAS. FADD (also designated MORT1) and TRADD bind to Fas and TNFR1, respectively. RIP is a death domain-containing serine/threonine kinase that binds to TRADD. RAIDD (also designated CRADD) was identified as a RIP binding protein. Both RAIDD and FADD can associate with members of the caspase family, providing a link between the activation of theTNFRs and the triggering of the cysteine protease cascade. The death domain-containing protein SIVA binds to the TNFR family member CD27 and appears to play a role in CD27 mediated apoptosis.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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