BS4058

antibody from Bioworld Technology, Inc
Targeting: PPP1R1B DARPP-32, FLJ20940
Provider product page for BS4058
Western blot
Immunohistochemistry

Antibody data

Product number
BS4058 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DARPP 32 (phospho T75) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human DARPP-32 around the phosphorylation site of Threonine 75.
Description
Dopaminergic signaling pathways, which are essential for multiple brain functions, are abnormal in several neurological disorders, such as schizophrenia, Parkinson£ªs disease and drug abuse. DARPP-32 (for dopamine and adenosine 3£ª,5£ª-monophosphate-regulated phosphoprotein of 32 kDa) is abundant in neurons that receive dopaminergic input. Activation of PKA and the consequent phosphorylation of DARPP-32 on threonine occurs in response to dopamine acting upon D1-like receptors. Dopamine interaction with D2-like receptors results in the inhibition of PKA activation, the activation of protein phosphatase 2B and the consequent dephosphorylation of DARPP-32. Neurotransmitters other than dopamine may also be able to stimulate the phosphorylation or dephosphorylation of DARPP-32. Phosphorylated DARPP-32 is a potent inhibitor of PP-1.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PPP1R1B protein structure - BS4058 shown in red.