CABT-L1539

antibody from Creative Diagnostics

Targeting: PPP1R1B DARPP-32, FLJ20940

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-L1539

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human DARPP-32 monoclonal antibody, clone L.046.5

Antibody type

Monoclonal

Description

Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

L.046.5

Storage

-20°C