BS7824

antibody from Bioworld Technology, Inc
Targeting: BEST1 BEST, BMD, RP50, VMD2
Provider product page for BS7824
Western blot
Immunohistochemistry

Antibody data

Product number
BS7824 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BEST1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human BEST1.
Description
?The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function. Best vitelliform macular dystrophy, known as Best disease, is an early-onset autosomal dominant condition in which accumulation of lipofuscin-like material within and beneath the RPE leads to progressive loss of central vision. The lipofuscin-like material in the macular area appears as a yellow mass like the yolk of an egg that later becomes darker and irregular in color, a process known as ¡ùscrambling the egg¡ì. Best disease is frequently a reflection of mutations in the Bestrophin gene, which encodes a protein containing four putative transmembrane domains and localizes to the basolateral plasma membrane of RPE cells. Human Bestrophin forms oligomeric chloride channels that are sensitive to intracellular calcium. Missense mutations at the Bestrophin locus reduces or abolishes Bestrophin protein mediated membrane current. The human Bestrophin gene encodes a 585 amino acid protein.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BEST1 protein structure - BS7824 shown in red.