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- References [26]
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- Product number
- ABIN152509 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Bestrophin 1 (BEST1) (C-Term) antibody
- Antibody type
- Monoclonal
- Description
- Unpurified
- Reactivity
- Human, Canine
- Host
- Mouse
- Epitope
- C-Term
- Isotype
- IgG
- Antibody clone number
- E6-6
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Effects of RPE-conditioned medium on the differentiation of hADSCs into RPE cells, and their proliferation and migration.
Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca2+-dependent Cl- currents in human RPE.
Survival of Transplanted Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Human Recipient for 22 Months.
Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.
Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro.
Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model.
Hydrogel for Simultaneous Tunable Growth Factor Delivery and Enhanced Viability of Encapsulated Cells in Vitro.
Stem cells as source for retinal pigment epithelium transplantation.
Ocular phenotype analysis of a family with biallelic mutations in the BEST1 gene.
The culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye.
A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells.
Generation of retinal pigment epithelial cells from human embryonic stem cell-derived spherical neural masses.
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.
Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies.
Functional characterization of bestrophin-1 missense mutations associated with autosomal recessive bestrophinopathy.
Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells.
Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium.
Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence.
Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.
Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells.
Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa.
Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease.
Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation.
Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics.
Bestrophin interacts physically and functionally with protein phosphatase 2A.
Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium.
Zhang Y, Zhang D, Wei W, Shen B, Wang Y, Zhang Y, Zhang Y, Ji J, Sun H, Luo M, Gu P
Experimental and therapeutic medicine 2017 Oct;14(4):3699-3707
Experimental and therapeutic medicine 2017 Oct;14(4):3699-3707
Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca2+-dependent Cl- currents in human RPE.
Li Y, Zhang Y, Xu Y, Kittredge A, Ward N, Chen S, Tsang SH, Yang T
eLife 2017 Oct 24;6
eLife 2017 Oct 24;6
Survival of Transplanted Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Human Recipient for 22 Months.
Shim SH, Kim G, Lee DR, Lee JE, Kwon HJ, Song WK
JAMA ophthalmology 2017 Mar 1;135(3):287-289
JAMA ophthalmology 2017 Mar 1;135(3):287-289
Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers.
Klingeborn M, Dismuke WM, Skiba NP, Kelly U, Stamer WD, Bowes Rickman C
Scientific reports 2017 Jul 7;7(1):4901
Scientific reports 2017 Jul 7;7(1):4901
Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro.
Kaneko Y, Pappas C, Tajiri N, Borlongan CV
Scientific reports 2016 Oct 21;6:35659
Scientific reports 2016 Oct 21;6:35659
Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model.
Uggenti C, Briant K, Streit AK, Thomson S, Koay YH, Baines RA, Swanton E, Manson FD
Disease models & mechanisms 2016 Nov 1;9(11):1317-1328
Disease models & mechanisms 2016 Nov 1;9(11):1317-1328
Hydrogel for Simultaneous Tunable Growth Factor Delivery and Enhanced Viability of Encapsulated Cells in Vitro.
Parker J, Mitrousis N, Shoichet MS
Biomacromolecules 2016 Feb 8;17(2):476-84
Biomacromolecules 2016 Feb 8;17(2):476-84
Stem cells as source for retinal pigment epithelium transplantation.
Bertolotti E, Neri A, Camparini M, Macaluso C, Marigo V
Progress in retinal and eye research 2014 Sep;42:130-44
Progress in retinal and eye research 2014 Sep;42:130-44
Ocular phenotype analysis of a family with biallelic mutations in the BEST1 gene.
Sharon D, Al-Hamdani S, Engelsberg K, Mizrahi-Meissonnier L, Obolensky A, Banin E, Sander B, Jensen H, Larsen M, Schatz P
American journal of ophthalmology 2014 Mar;157(3):697-709.e1-2
American journal of ophthalmology 2014 Mar;157(3):697-709.e1-2
The culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye.
Blenkinsop TA, Salero E, Stern JH, Temple S
Methods in molecular biology (Clifton, N.J.) 2013;945:45-65
Methods in molecular biology (Clifton, N.J.) 2013;945:45-65
A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells.
Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ
Stem cells translational medicine 2013 May;2(5):341-54
Stem cells translational medicine 2013 May;2(5):341-54
Generation of retinal pigment epithelial cells from human embryonic stem cell-derived spherical neural masses.
Cho MS, Kim SJ, Ku SY, Park JH, Lee H, Yoo DH, Park UC, Song SA, Choi YM, Yu HG
Stem cell research 2012 Sep;9(2):101-9
Stem cell research 2012 Sep;9(2):101-9
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.
Krohne TU, Westenskow PD, Kurihara T, Friedlander DF, Lehmann M, Dorsey AL, Li W, Zhu S, Schultz A, Wang J, Siuzdak G, Ding S, Friedlander M
Stem cells translational medicine 2012 Feb;1(2):96-109
Stem cells translational medicine 2012 Feb;1(2):96-109
Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies.
Guziewicz KE, Slavik J, Lindauer SJ, Aguirre GD, Zangerl B
Investigative ophthalmology & visual science 2011 Jun 23;52(7):4497-505
Investigative ophthalmology & visual science 2011 Jun 23;52(7):4497-505
Functional characterization of bestrophin-1 missense mutations associated with autosomal recessive bestrophinopathy.
Davidson AE, Millar ID, Burgess-Mullan R, Maher GJ, Urquhart JE, Brown PD, Black GC, Manson FD
Investigative ophthalmology & visual science 2011 Jun 1;52(6):3730-6
Investigative ophthalmology & visual science 2011 Jun 1;52(6):3730-6
Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells.
Harness JV, Turovets NA, Seiler MJ, Nistor G, Altun G, Agapova LS, Ferguson D, Laurent LC, Loring JF, Keirstead HS
PloS one 2011 Jan 7;6(1):e14499
PloS one 2011 Jan 7;6(1):e14499
Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium.
Zhang Y, Patil RV, Marmorstein AD
Molecular vision 2010 Feb 10;16:200-6
Molecular vision 2010 Feb 10;16:200-6
Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence.
Feng Q, Lu SJ, Klimanskaya I, Gomes I, Kim D, Chung Y, Honig GR, Kim KS, Lanza R
Stem cells (Dayton, Ohio) 2010 Apr;28(4):704-12
Stem cells (Dayton, Ohio) 2010 Apr;28(4):704-12
Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.
Lu B, Malcuit C, Wang S, Girman S, Francis P, Lemieux L, Lanza R, Lund R
Stem cells (Dayton, Ohio) 2009 Sep;27(9):2126-35
Stem cells (Dayton, Ohio) 2009 Sep;27(9):2126-35
Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells.
Buchholz DE, Hikita ST, Rowland TJ, Friedrich AM, Hinman CR, Johnson LV, Clegg DO
Stem cells (Dayton, Ohio) 2009 Oct;27(10):2427-34
Stem cells (Dayton, Ohio) 2009 Oct;27(10):2427-34
Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosa.
Davidson AE, Millar ID, Urquhart JE, Burgess-Mullan R, Shweikh Y, Parry N, O'Sullivan J, Maher GJ, McKibbin M, Downes SM, Lotery AJ, Jacobson SG, Brown PD, Black GC, Manson FD
American journal of human genetics 2009 Nov;85(5):581-92
American journal of human genetics 2009 Nov;85(5):581-92
Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease.
Guziewicz KE, Zangerl B, Lindauer SJ, Mullins RF, Sandmeyer LS, Grahn BH, Stone EM, Acland GM, Aguirre GD
Investigative ophthalmology & visual science 2007 May;48(5):1959-67
Investigative ophthalmology & visual science 2007 May;48(5):1959-67
Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation.
Mullins RF, Oh KT, Heffron E, Hageman GS, Stone EM
Archives of ophthalmology (Chicago, Ill. : 1960) 2005 Nov;123(11):1588-94
Archives of ophthalmology (Chicago, Ill. : 1960) 2005 Nov;123(11):1588-94
Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics.
Klimanskaya I, Hipp J, Rezai KA, West M, Atala A, Lanza R
Cloning and stem cells 2004;6(3):217-45
Cloning and stem cells 2004;6(3):217-45
Bestrophin interacts physically and functionally with protein phosphatase 2A.
Marmorstein LY, McLaughlin PJ, Stanton JB, Yan L, Crabb JW, Marmorstein AD
The Journal of biological chemistry 2002 Aug 23;277(34):30591-7
The Journal of biological chemistry 2002 Aug 23;277(34):30591-7
Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium.
Marmorstein AD, Marmorstein LY, Rayborn M, Wang X, Hollyfield JG, Petrukhin K
Proceedings of the National Academy of Sciences of the United States of America 2000 Nov 7;97(23):12758-63
Proceedings of the National Academy of Sciences of the United States of America 2000 Nov 7;97(23):12758-63
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