Antibody data
- Antibody Data
- Antigen structure
- References [108]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
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- Product number
- 12186-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12186-1-AP, RRID:AB_2266320
- Product name
- MFN2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MFN2 antibody (Cat. #12186-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chronic Hypoxia Inhibits Respiratory Complex IV Activity and Disrupts Mitochondrial Dynamics in the Fetal Guinea Pig Forebrain.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mitochondrial Fusion Potentially Regulates a Metabolic Change in Tibetan Chicken Embryonic Brain During Hypoxia.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.
Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson's Disease.
Cordycepin Decreases Ischemia/Reperfusion Injury in Diabetic Hearts via Upregulating AMPK/Mfn2-dependent Mitochondrial Fusion.
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.
Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.
Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes.
Astragaloside II Ameliorated Podocyte Injury and Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca2+ homeostasis.
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder.
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
Mitocytosis, a migrasome-mediated mitochondrial quality-control process.
Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.
CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production.
OPA1 haploinsufficiency due to a novel splicing variant resulting in mitochondrial dysfunction without mitochondrial DNA depletion.
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
PINCH-1 promotes Δ1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma.
Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics.
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions.
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.
A Long-Term Enriched Environment Ameliorates the Accelerated Age-Related Memory Impairment Induced by Gestational Administration of Lipopolysaccharide: Role of Plastic Mitochondrial Quality Control.
Bu-Yin-Qian-Zheng Formula Ameliorates MPP+-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.
Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis.
The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy.
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity.
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
ChREBP-β regulates thermogenesis in brown adipose tissue.
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Chicken thalamic injury induced by copper (II) or / and arsenite exposure involves oxidative stress and inflammation-induced apoptosis.
Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury.
Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury.
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats.
Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP.
Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).
DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission.
Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts.
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.
TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation.
An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle.
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens.
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state.
Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer.
Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1.
Quebedeaux TM, Song H, Giwa-Otusajo J, Thompson LP
Reproductive sciences (Thousand Oaks, Calif.) 2022 Jan;29(1):184-192
Reproductive sciences (Thousand Oaks, Calif.) 2022 Jan;29(1):184-192
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618
Frontiers in cell and developmental biology 2021;9:673618
Mitochondrial Fusion Potentially Regulates a Metabolic Change in Tibetan Chicken Embryonic Brain During Hypoxia.
Tang Q, Ding C, Xu Q, Bai Y, Xu Q, Wang K, Fang M
Frontiers in cell and developmental biology 2021;9:585166
Frontiers in cell and developmental biology 2021;9:585166
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
Oxyberberine Prevented Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Mitophagy.
Zhao R, Wang B, Wang D, Wu B, Ji P, Tan D
Oxidative medicine and cellular longevity 2021;2021:6675264
Oxidative medicine and cellular longevity 2021;2021:6675264
Dl-3-n-Butylphthalide Alleviates Behavioral and Cognitive Symptoms Via Modulating Mitochondrial Dynamics in the A53T-α-Synuclein Mouse Model of Parkinson's Disease.
Li H, Wang H, Zhang L, Wang M, Li Y
Frontiers in neuroscience 2021;15:647266
Frontiers in neuroscience 2021;15:647266
Cordycepin Decreases Ischemia/Reperfusion Injury in Diabetic Hearts via Upregulating AMPK/Mfn2-dependent Mitochondrial Fusion.
Yu H, Hong X, Liu L, Wu Y, Xie X, Fang G, Zhi S
Frontiers in pharmacology 2021;12:754005
Frontiers in pharmacology 2021;12:754005
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.
Khodzhaeva V, Schreiber Y, Geisslinger G, Brandes RP, Brüne B, Namgaladze D
Frontiers in immunology 2021;12:723683
Frontiers in immunology 2021;12:723683
Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer's Disease.
Cheng D, Yang XJ, Zhang L, Qin ZS, Li WQ, Xu HC, Zhang ZJ
Frontiers in pharmacology 2021;12:690256
Frontiers in pharmacology 2021;12:690256
Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes.
Meng TT, Wang W, Meng FL, Wang SY, Wu HH, Chen JM, Zheng Y, Wang GX, Zhang MX, Li Y, Su GH
Frontiers in physiology 2021;12:650055
Frontiers in physiology 2021;12:650055
Astragaloside II Ameliorated Podocyte Injury and Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats.
Su J, Gao C, Xie L, Fan Y, Shen Y, Huang Q, Wang N, Xu Y, Yang N, Gui D
Frontiers in pharmacology 2021;12:638422
Frontiers in pharmacology 2021;12:638422
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.
Zeng S, Zhao Z, Zheng S, Wu M, Song X, Li Y, Zheng Y, Liu B, Chen L, Gao C, Liu H
Redox biology 2021 Sep;45:102058
Redox biology 2021 Sep;45:102058
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction.
Ding YQ, Zhang YH, Lu J, Li B, Yu WJ, Yue ZB, Hu YH, Wang PX, Li JY, Cai SD, Ye JT, Liu PQ
Acta pharmacologica Sinica 2021 Sep;42(9):1422-1436
Acta pharmacologica Sinica 2021 Sep;42(9):1422-1436
Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.
Liu W, Liang L, Zhang Q, Li Y, Yan S, Tang T, Ren Y, Mo J, Liu F, Chen X, Lan T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153650
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153650
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca2+ homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
SIRT3 protects bovine mammary epithelial cells from heat stress damage by activating the AMPK signaling pathway.
Sun XC, Wang Y, Zeng HF, Xi YM, Lin H, Han ZY, Chen KL
Cell death discovery 2021 Oct 21;7(1):304
Cell death discovery 2021 Oct 21;7(1):304
Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorder.
Zhang X, Zhang B, Zhang C, Sun G, Sun X
Cell death & disease 2021 Nov 22;12(12):1098
Cell death & disease 2021 Nov 22;12(12):1098
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.
Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK
Science advances 2021 Nov 12;7(46):eabj0722
Science advances 2021 Nov 12;7(46):eabj0722
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Zhong S, Li L, Liang N, Zhang L, Xu X, Chen S, Yin H
Redox biology 2021 May;41:101919
Redox biology 2021 May;41:101919
Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction.
Wang HL, Xing GD, Qian Y, Sun XF, Zhong JF, Chen KL
Ecotoxicology and environmental safety 2021 May;214:112078
Ecotoxicology and environmental safety 2021 May;214:112078
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, Fan H, Meng T, He Z, Huang H, Gong Q, Zhu D, Xu Y, He P, Li L, Feng D
Autophagy 2021 May;17(5):1142-1156
Autophagy 2021 May;17(5):1142-1156
LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
Ma Y, Wang L, He F, Yang J, Ding Y, Ge S, Fan X, Zhou Y, Xu X, Jia R
Cancer letters 2021 May 28;506:67-82
Cancer letters 2021 May 28;506:67-82
Mitocytosis, a migrasome-mediated mitochondrial quality-control process.
Jiao H, Jiang D, Hu X, Du W, Ji L, Yang Y, Li X, Sho T, Wang X, Li Y, Wu YT, Wei YH, Hu X, Yu L
Cell 2021 May 27;184(11):2896-2910.e13
Cell 2021 May 27;184(11):2896-2910.e13
Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis.
Liang X, Lin F, Ding Y, Zhang Y, Li M, Zhou X, Meng Q, Ma X, Wei L, Fan H, Liu Z
Stem cell research & therapy 2021 May 20;12(1):295
Stem cell research & therapy 2021 May 20;12(1):295
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Molecular nutrition & food research 2021 Jul;65(14):e2001076
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.
Du J, Wang X, Li Y, Ren X, Zhou Y, Hu W, Zhou C, Jing Q, Yang C, Wang L, Li H, Fang L, Zhou Y, Tong X, Wang Y
Cell death & disease 2021 Jul 15;12(7):705
Cell death & disease 2021 Jul 15;12(7):705
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure.
Wang JL, Ding HR, Pan CY, Shi XL, Ren HZ
Cell death & disease 2021 Jan 21;12(1):111
Cell death & disease 2021 Jan 21;12(1):111
CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease.
Hu Z, Mao C, Wang H, Zhang Z, Zhang S, Luo H, Tang M, Yang J, Yuan Y, Wang Y, Liu Y, Fan L, Zhang Q, Yao D, Liu F, Schisler JC, Shi C, Xu Y
Aging 2021 Jan 2;13(1):1458-1472
Aging 2021 Jan 2;13(1):1458-1472
DsbA-L deficiency in T cells promotes diet-induced thermogenesis through suppressing IFN-γ production.
Zhou H, Peng X, Hu J, Wang L, Luo H, Zhang J, Zhang Y, Li G, Ji Y, Zhang J, Bai J, Liu M, Zhou Z, Liu F
Nature communications 2021 Jan 12;12(1):326
Nature communications 2021 Jan 12;12(1):326
OPA1 haploinsufficiency due to a novel splicing variant resulting in mitochondrial dysfunction without mitochondrial DNA depletion.
Sun C, Wu X, Bai HX, Wang C, Liu Z, Yang C, Lu Y, Jiang P
Ophthalmic genetics 2021 Feb;42(1):45-52
Ophthalmic genetics 2021 Feb;42(1):45-52
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
PINCH-1 promotes Δ1-pyrroline-5-carboxylate synthase expression and contributes to proline metabolic reprogramming in lung adenocarcinoma.
Cui C, Wang J, Guo L, Wu C
Amino acids 2021 Dec;53(12):1875-1890
Amino acids 2021 Dec;53(12):1875-1890
Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics.
Wang LT, He PC, Li AQ, Cao KX, Yan JW, Guo S, Jiang L, Yao L, Dai XY, Feng D, Xu YM, Tan N
Acta pharmacologica Sinica 2021 Dec;42(12):2033-2045
Acta pharmacologica Sinica 2021 Dec;42(12):2033-2045
Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation.
Meng Q, Zaharieva EK, Sasatani M, Kobayashi J
Redox report : communications in free radical research 2021 Dec;26(1):160-169
Redox report : communications in free radical research 2021 Dec;26(1):160-169
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Xue W, Liu Q, Han J, Luo R, Feng J, Liu J, Guo T, Peng X, Hu T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.
Cheng D, Su L, Wang X, Li X, Li L, Hu M, Lu Y
BMC complementary medicine and therapies 2021 Aug 9;21(1):206
BMC complementary medicine and therapies 2021 Aug 9;21(1):206
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions.
Du Y, Wang J, Xiong J, Fang N, Ji WK
Molecular biology of the cell 2021 Aug 1;32(16):1474-1486
Molecular biology of the cell 2021 Aug 1;32(16):1474-1486
Mst1 Knockout Alleviates Mitochondrial Fission and Mitigates Left Ventricular Remodeling in the Development of Diabetic Cardiomyopathy.
Feng X, Wang S, Yang X, Lin J, Man W, Dong Y, Zhang Y, Zhao Z, Wang H, Sun D
Frontiers in cell and developmental biology 2020;8:628842
Frontiers in cell and developmental biology 2020;8:628842
Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway.
Ye L, Wu H, Xu W
BioMed research international 2020;2020:9803024
BioMed research international 2020;2020:9803024
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Feng LX, Zhao F, Liu Q, Peng JC, Duan XJ, Yan P, Wu X, Wang HS, Deng YH, Duan SB
Oxidative medicine and cellular longevity 2020;2020:6123459
Oxidative medicine and cellular longevity 2020;2020:6123459
Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins.
Li Y, Yu H, Chen C, Li S, Zhang Z, Xu H, Zhu F, Liu J, Spencer PS, Dai Z, Yang X
Oxidative medicine and cellular longevity 2020;2020:5408452
Oxidative medicine and cellular longevity 2020;2020:5408452
A Long-Term Enriched Environment Ameliorates the Accelerated Age-Related Memory Impairment Induced by Gestational Administration of Lipopolysaccharide: Role of Plastic Mitochondrial Quality Control.
Zhuang ZQ, Zhang ZZ, Zhang YM, Ge HH, Sun SY, Zhang P, Chen GH
Frontiers in cellular neuroscience 2020;14:559182
Frontiers in cellular neuroscience 2020;14:559182
Bu-Yin-Qian-Zheng Formula Ameliorates MPP+-Induced Mitochondrial Dysfunction in Parkinson's Disease via Parkin.
Ma HJ, Gai C, Chai Y, Feng WD, Cheng CC, Zhang JK, Zhang YX, Yang LP, Guo ZY, Gao YS, Sun HM
Frontiers in pharmacology 2020;11:577017
Frontiers in pharmacology 2020;11:577017
Promotion of mitochondrial fusion protects against developmental PBDE-47 neurotoxicity by restoring mitochondrial homeostasis and suppressing excessive apoptosis.
Dong L, Li P, Yang K, Liu L, Gao H, Zhou G, Zhao Q, Xia T, Wang A, Zhang S
Theranostics 2020;10(3):1245-1261
Theranostics 2020;10(3):1245-1261
Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis.
Wei S, Qiu T, Wang N, Yao X, Jiang L, Jia X, Tao Y, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X
Environmental research 2020 Sep;188:109824
Environmental research 2020 Sep;188:109824
The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy.
Jin C, Miao X, Zhong Y, Han J, Liu Q, Zhu J, Xia X, Peng X
Food & function 2020 Sep 23;11(9):7456-7467
Food & function 2020 Sep 23;11(9):7456-7467
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S
Communications biology 2020 Oct 20;3(1):592
Communications biology 2020 Oct 20;3(1):592
Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity.
Zhang Y, Ma Y, Xiao Y, Lu C, Xiao F
Ecotoxicology and environmental safety 2020 Oct 15;203:110928
Ecotoxicology and environmental safety 2020 Oct 15;203:110928
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.
Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, Su W, Bao R, Ran J, Wu C
Nature communications 2020 Oct 1;11(1):4913
Nature communications 2020 Oct 1;11(1):4913
HIF-1α ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics.
Jiang N, Zhao H, Han Y, Li L, Xiong S, Zeng L, Xiao Y, Wei L, Xiong X, Gao P, Yang M, Liu Y, Sun L
Cell proliferation 2020 Nov;53(11):e12909
Cell proliferation 2020 Nov;53(11):e12909
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J
Autophagy 2020 May;16(5):797-810
Autophagy 2020 May;16(5):797-810
ChREBP-β regulates thermogenesis in brown adipose tissue.
Wei C, Ma X, Su K, Qi S, Zhu Y, Lin J, Wang C, Yang R, Chen X, Wang W, Zhang WJ
The Journal of endocrinology 2020 Jun;245(3):343-356
The Journal of endocrinology 2020 Jun;245(3):343-356
Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.
Kai J, Yang X, Wang Z, Wang F, Jia Y, Wang S, Tan S, Chen A, Shao J, Zhang F, Zhang Z, Zheng S
Free radical biology & medicine 2020 Jun;153:89-102
Free radical biology & medicine 2020 Jun;153:89-102
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Zhang X, Zhao D, Wu W, Ali Shah SZ, Lai M, Yang D, Li J, Guan Z, Li W, Gao H, Zhao H, Zhou X, Yang L
Aging 2020 Jun 10;12(11):11139-11151
Aging 2020 Jun 10;12(11):11139-11151
Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway.
Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, Li L, Zhang L
Biochemical pharmacology 2020 Jul;177:113997
Biochemical pharmacology 2020 Jul;177:113997
Chicken thalamic injury induced by copper (II) or / and arsenite exposure involves oxidative stress and inflammation-induced apoptosis.
Wang D, Zong C, Cheng K
Ecotoxicology and environmental safety 2020 Jul 1;197:110554
Ecotoxicology and environmental safety 2020 Jul 1;197:110554
Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury.
Zhao Y, Guo R, Li L, Li S, Fan G, Zhao X, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Dec;132:110897
Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Otomo H, Nara M, Kato S, Shimizu T, Suganuma Y, Sato T, Morii T, Yamada Y, Fujita H
Metabolism: clinical and experimental 2020 Dec;113:154405
Metabolism: clinical and experimental 2020 Dec;113:154405
Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.
Ma D, Zheng B, Liu HL, Zhao YB, Liu X, Zhang XH, Li Q, Shi WB, Suzuki T, Wen JK
PLoS biology 2020 Aug;18(8):e3000808
PLoS biology 2020 Aug;18(8):e3000808
TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury.
Zhang C, Jia Y, Liu B, Wang G, Zhang Y
Life sciences 2020 Aug 1;254:117762
Life sciences 2020 Aug 1;254:117762
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Chen KL, Wang HL, Jiang LZ, Qian Y, Yang CX, Chang WW, Zhong JF, Xing GD
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
In vitro cellular & developmental biology. Animal 2020 Apr;56(4):322-331
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, Peng S, Sun X, Yu M, Chen H, Wang Y, Zhang L, Liu N, Du H, Zhao D, Zhang W
Aging and disease 2020 Apr;11(2):269-285
Aging and disease 2020 Apr;11(2):269-285
DsbA-L deficiency exacerbates mitochondrial dysfunction of tubular cells in diabetic kidney disease.
Gao P, Yang M, Chen X, Xiong S, Liu J, Sun L
Clinical science (London, England : 1979) 2020 Apr 17;134(7):677-694
Clinical science (London, England : 1979) 2020 Apr 17;134(7):677-694
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, Wang L, Yan J, Nikolaevna SE, Zhao Y
Oxidative medicine and cellular longevity 2019;2019:5406468
Oxidative medicine and cellular longevity 2019;2019:5406468
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762
Oxidative medicine and cellular longevity 2019;2019:4508762
The Neuroprotective Effect of Hemin and the Related Mechanism in Sevoflurane Exposed Neonatal Rats.
Yang F, Shan Y, Tang Z, Wu X, Bi C, Zhang Y, Gao Y, Liu H
Frontiers in neuroscience 2019;13:537
Frontiers in neuroscience 2019;13:537
Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP.
Gai C, Feng WD, Qiang TY, Ma HJ, Chai Y, Zhang SJ, Guo ZY, Hu JH, Sun HM
Frontiers in pharmacology 2019;10:372
Frontiers in pharmacology 2019;10:372
Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm).
Miao X, Li W, Niu B, Li J, Sun J, Qin M, Zhou Z
Journal of applied toxicology : JAT 2019 Oct;39(10):1424-1432
Journal of applied toxicology : JAT 2019 Oct;39(10):1424-1432
DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity.
Yang M, Zhao L, Gao P, Zhu X, Han Y, Chen X, Li L, Xiao Y, Wei L, Li C, Xiao L, Yuan S, Liu F, Dong LQ, Kanwar YS, Sun L
EBioMedicine 2019 May;43:607-619
EBioMedicine 2019 May;43:607-619
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children.
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, Dong L, Xu C, Tian Z, Luo C, Liu L, Zhang S, Wang A
Archives of toxicology 2019 Mar;93(3):709-726
Archives of toxicology 2019 Mar;93(3):709-726
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
Shen M, Wang F, Li M, Sah N, Stockton ME, Tidei JJ, Gao Y, Korabelnikov T, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, van Praag H, Zhao X
Nature neuroscience 2019 Mar;22(3):386-400
Nature neuroscience 2019 Mar;22(3):386-400
CDDO-Me Selectively Attenuates CA1 Neuronal Death Induced by Status Epilepticus via Facilitating Mitochondrial Fission Independent of LONP1.
Kim JE, Park H, Choi SH, Kong MJ, Kang TC
Cells 2019 Aug 5;8(8)
Cells 2019 Aug 5;8(8)
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.
Lavdovskaia E, Kolander E, Steube E, Mai MM, Urlaub H, Richter-Dennerlein R
Nucleic acids research 2018 Sep 19;46(16):8471-8482
Nucleic acids research 2018 Sep 19;46(16):8471-8482
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F
Cell death & disease 2018 Jun 13;9(6):700
Cell death & disease 2018 Jun 13;9(6):700
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Human molecular genetics 2018 Jul 15;27(14):2502-2516
Human molecular genetics 2018 Jul 15;27(14):2502-2516
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Syu YW, Lai HW, Jiang CL, Tsai HY, Lin CC, Lee YC
Human molecular genetics 2018 Jan 15;27(2):307-321
Human molecular genetics 2018 Jan 15;27(2):307-321
Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.
Lee CA, Chin LS, Li L
Protein & cell 2018 Aug;9(8):693-716
Protein & cell 2018 Aug;9(8):693-716
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854
Cell research 2018 Aug;28(8):833-854
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, Guan Z
PPAR research 2017;2017:4089214
PPAR research 2017;2017:4089214
Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission.
Ko SH, Choi GE, Oh JY, Lee HJ, Kim JS, Chae CW, Choi D, Han HJ
Scientific reports 2017 Oct 3;7(1):12582
Scientific reports 2017 Oct 3;7(1):12582
Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia.
Zhou X, Han TL, Chen H, Baker PN, Qi H, Zhang H
Experimental cell research 2017 Oct 1;359(1):195-204
Experimental cell research 2017 Oct 1;359(1):195-204
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts.
Chung E, Joiner HE, Skelton T, Looten KD, Manczak M, Reddy PH
Physiological reports 2017 Mar;5(5)
Physiological reports 2017 Mar;5(5)
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin.
Liu Y, Hu Y, E Q, Zuo J, Yang L, Liu W
Scientific reports 2017 Mar 2;7:43097
Scientific reports 2017 Mar 2;7:43097
TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation.
Ko AR, Kang TC
Neuropharmacology 2017 Jul 15;121:120-129
Neuropharmacology 2017 Jul 15;121:120-129
An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle.
Niemann J, Johne C, Schröder S, Koch F, Ibrahim SM, Schultz J, Tiedge M, Baltrusch S
Free radical biology & medicine 2017 Jan;102:174-187
Free radical biology & medicine 2017 Jan;102:174-187
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, Zhao Y, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497
Chemosphere 2017 Dec;189:489-497
Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens.
Xu Z, Jin X, Pan T, Liu T, Wan N, Li S
Oncotarget 2017 Aug 8;8(32):52629-52641
Oncotarget 2017 Aug 8;8(32):52629-52641
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
Wu H, Li Z, Wang Y, Yang P, Li Z, Li H, Wu C
American journal of cancer research 2016;6(10):2221-2234
American journal of cancer research 2016;6(10):2221-2234
Exogenous H2S modulates mitochondrial fusion-fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state.
Sun A, Wang Y, Liu J, Yu X, Sun Y, Yang F, Dong S, Wu J, Zhao Y, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:36
Cell & bioscience 2016;6:36
Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Sharoar MG, Shi Q, Ge Y, He W, Hu X, Perry G, Zhu X, Yan R
Molecular psychiatry 2016 Sep;21(9):1263-71
Molecular psychiatry 2016 Sep;21(9):1263-71
SAMM50 Affects Mitochondrial Morphology through the Association of Drp1 in Mammalian Cells.
Liu S, Gao Y, Zhang C, Li H, Pan S, Wang X, Du S, Deng Z, Wang L, Song Z, Chen S
FEBS letters 2016 May;590(9):1313-23
FEBS letters 2016 May;590(9):1313-23
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.
Wang Y, Wu F, Pan H, Zheng W, Feng C, Wang Y, Deng Z, Wang L, Luo J, Chen S
Scientific reports 2016 Feb 29;6:22244
Scientific reports 2016 Feb 29;6:22244
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y, Sun L
International journal of oncology 2016 Dec;49(6):2507-2519
International journal of oncology 2016 Dec;49(6):2507-2519
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy PH
Human molecular genetics 2016 Dec 1;25(23):5148-5166
Human molecular genetics 2016 Dec 1;25(23):5148-5166
FUS Interacts with HSP60 to Promote Mitochondrial Damage.
Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY
PLoS genetics 2015 Sep;11(9):e1005357
PLoS genetics 2015 Sep;11(9):e1005357
Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.
Ota K, Obayashi M, Ozaki K, Ichinose S, Kakita A, Tada M, Takahashi H, Ando N, Eishi Y, Mizusawa H, Ishikawa K
Acta neuropathologica communications 2014 Sep 11;2:136
Acta neuropathologica communications 2014 Sep 11;2:136
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer.
Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, Salgia R, Husain AN, Wietholt C, Archer SL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):2175-86
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):2175-86
Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1.
Kar R, Mishra N, Singha PK, Venkatachalam MA, Saikumar P
Biochemical and biophysical research communications 2010 Sep 3;399(4):548-54
Biochemical and biophysical research communications 2010 Sep 3;399(4):548-54
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 12186-1-AP(MFN2 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MFN2 (IP:12186-1-AP, 3ug; Detection:12186-1-AP 1:1000) with mouse kidney tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MFN2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MFN2. This antibody recognizes human,mouse,rat antigen. The MFN2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.