TAC3

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Description

Tachykinin precursor 3

Tissue specificity

Tissue enriched (placenta)

Subcell location

Vesicles

Predicted location

Secreted in female reproductive system

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (57010000 - 57028883)

Ensembl ID

ENSG00000166863  (ver. 103.38)

Orthologs

Mouse Tac2: ENSMUSG00000025400

UniProt

Q9UHF0

neXtProt

NX_Q9UHF0

Human splice variants
Mouse splice variants

Protein structure