PCDH11X

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its Y homolog, despite divergence leading to coding region changes, is the most closely related cadherin family member. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Disruption of this gene may be associated with developmental dyslexia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Description

Protocadherin 11 X-linked

Tissue specificity

Group enriched (brain, ovary)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

X (91779261 - 92623230)

Ensembl ID

ENSG00000102290  (ver. 103.38)

Orthologs

-

UniProt

Q9BZA7

neXtProt

NX_Q9BZA7

Human splice variants

Protein structure