GGT5

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Description

Gamma-glutamyltransferase 5

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli fibrillar center

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (24219654 - 24245108)

Ensembl ID

ENSG00000099998  (ver. 103.38)

Orthologs

Mouse Ggt5: ENSMUSG00000006344

UniProt

P36269

neXtProt

NX_P36269

Human splice variants
Mouse splice variants

Protein structure