AMM03617G

antibody from Leading Biology

Targeting: HERPUD1 HERP, KIAA0025, Mif1, SUP

Western blot (Recommended by provider)

Antibody Data

Product number

AMM03617G

Provider

Leading Biology

Product name

HERPUD1 Antibody (monoclonal) (M01)

Antibody type

Monoclonal

Description

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

3E11

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.