BS1271

antibody from Bioworld Technology, Inc

Targeting: DCTN2 DCTN-50, RBP50

Immunohistochemistry

Antibody data

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Validation data

Product number: BS1271 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS1271, RRID:AB_1663329
Product name: Dynactin 2 (L371) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 340-390 of Human Dynactin 2.
Description: Dynactin is a multisubunit complex that functions as a binding partner for the Dynein microtubule motor. Dynactin-Dynein binding may be required for most, if not all, cytoplasmic Dynein-driven activities and is thought to contribute to the functional diversity of Dynein. Dynactin 2, also known as DCTN2, Dynamitin or DCTN50, is a peripheral membrane protein that is one of many subunits in the Dynactin complex. Like other Dynactin subunits, Dynactin 2 mediates Dynein-organelle binding and helps to regulate chromosome alignment during prometaphase and spindle organization during mitosis. Overexpression of Dynactin 2 disrupts the Dynactin-Dynein complex, thus inhibiting retrograde axonal transport and causing motor neuron degeneration. Additionally, overexpression of Dynactin 2 may disrupt the cell cycle and lead to osteosarcoma, suggesting a possible role for Dynactin 2 in carcinogenesis
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

DCTN2 protein structure - BS1271 shown in red.