MAB1080

antibody from R&D Systems

Targeting: CTSV CTSL2, CTSU

Western blot (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

MAB1080

Provider

R&D Systems

Product name

Human Cathepsin V Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human Cathepsin V in direct ELISAs and Western blots. In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Cathepsin H and recombinant human (rh) Cathepsin K is observed and no cross-reactivity with rhCathepsin B, C, L, O, S, Z, rmCathepsin B, C, F, or Z is observed.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

O60911


Isotype

IgG

Antibody clone number

182016

Vial size

500 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.

Bergboer JG, Tjabringa GS, Kamsteeg M, van Vlijmen-Willems IM, Rodijk-Olthuis D, Jansen PA, Thuret JY, Narita M, Ishida-Yamamoto A, Zeeuwen PL, Schalkwijk J
The American journal of pathology 2011 Apr;178(4):1470-7

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Nuclear cysteine cathepsin variants in thyroid carcinoma cells.

Tedelind S, Poliakova K, Valeta A, Hunegnaw R, Yemanaberhan EL, Heldin NE, Kurebayashi J, Weber E, Kopitar-Jerala N, Turk B, Bogyo M, Brix K
Biological chemistry 2010 Aug;391(8):923-35

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Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane.

Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK
Investigative ophthalmology & visual science 2007 Feb;48(2):644-51

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Cell type-specific functions of the lysosomal protease cathepsin L in the heart.

Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Hagemann S, Vasiljeva O, Günther T, Schüle R, Peters C, Reinheckel T
The Journal of biological chemistry 2007 Dec 21;282(51):37045-52

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Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.

Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL
The Journal of biological chemistry 2006 Jun 9;281(23):15893-9