KAZN

This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]

Description

Kazrin, periplakin interacting protein

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (13892792 - 15118043)

Ensembl ID

ENSG00000189337  (ver. 103.38)

Orthologs

Mouse Kazn: ENSMUSG00000040606

UniProt

Q674X7

neXtProt

NX_Q674X7

Human splice variants
Mouse splice variants

Protein structure