22170-1-AP

antibody from Proteintech Group

Targeting: CPT1B CPT1-M, M-CPT1

Provider product page for 22170-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [51]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 22170-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22170-1-AP, RRID:AB_2713959
Product name: CPT1B-specific antibody
Antibody type: Polyclonal
Description: KD/KO validated CPT1B-specific antibody (Cat. #22170-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CPT1B protein structure - 22170-1-AP shown in red.

Submitted references 2-Methoxyestradiol ameliorates doxorubicin-induced cardiotoxicity by regulating the expression of GLUT4 and CPT-1B in female rats.

Sobhy MH, Ismail A, Abdel-Hamid MS, Wagih M, Kamel M
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):7129-7139

APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.

Zhao H, Cheng X, Yan L, Mi F, Wang W, Hu Y, Liu X, Fan Y, Min Q, Wang Y, Zhang W, Wu Q, Zhan Q
Cell communication and signaling : CCS 2024 May 23;22(1):283

Low phosphorus increases hepatic lipid deposition, oxidative stress and inflammatory response via Acetyl-CoA carboxylase-dependent manner in zebrafish liver cells.

Lin J, Zhang J, Dai W, Li X, Mohsen M, Li X, Lu K, Song K, Wang L, Zhang C
Fish & shellfish immunology 2024 Mar;146:109387

Procyanidin B1 and Coumaric Acid from Highland Barley Alleviated High-Fat-Diet-Induced Hyperlipidemia by Regulating PPARα-Mediated Hepatic Lipid Metabolism and Gut Microbiota in Diabetic C57BL/6J Mice.

Liu Z, Liu J, Tang R, Zhang Z, Tian S
Foods (Basel, Switzerland) 2024 Jun 12;13(12)

Dietary oleic acid intake increases the proportion of type 1 and 2X muscle fibers in mice.

Komiya Y, Iseki S, Ochiai M, Takahashi Y, Yokoyama I, Suzuki T, Tatsumi R, Sawano S, Mizunoya W, Arihara K
Scientific reports 2024 Jan 8;14(1):755

Defects in integrin complex formation promote CHKB-mediated muscular dystrophy.

Tavasoli M, McMaster CR
Life science alliance 2024 Aug;7(8)

Alternating current electromagnetic field exposure lessens intramyocellular lipid accumulation due to high-fat feeding via enhanced lipid metabolism in mice.

Nakanishi R, Tanaka M, Nisa BU, Shimizu S, Hirabayashi T, Tanaka M, Maeshige N, Roy RR, Fujino H
PloS one 2023;18(11):e0289086

Transgenic mice producing the trans 10, cis 12-conjugated linoleic acid present reduced adiposity and increased thermogenesis and fibroblast growth factor 21 (FGF21).

Rao Y, Li SL, Li MJ, Wang BZ, Wang YY, Liang LW, Yu S, Liu ZP, Cui S, Gou KM
The Journal of nutritional biochemistry 2023 Oct;120:109419

The Enhancement of Acylcarnitine Metabolism by 5-Heptadecylresorcinol in Brown Adipose Tissue Contributes to Improving Glucose and Lipid Levels in Aging Male Mice.

Zhang K, Jiang L, Xue L, Wang Y, Sun Y, Fan M, Qian H, Wang L, Li Y
Nutrients 2023 Oct 29;15(21)

Transcriptome Analysis Revealed Potential Genes of Skeletal Muscle Thermogenesis in Mashen Pigs and Large White Pigs under Cold Stress.

Li W, Chen Y, Zhang Y, Zhao N, Zhang W, Shi M, Zhao Y, Cai C, Lu C, Gao P, Guo X, Li B, Kim SW, Yang Y, Cao G
International journal of molecular sciences 2023 Oct 24;24(21)

Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.

Li C, Zhang X, Li J, Liang L, Zeng J, Wen M, Pan L, Lv D, Liu M, Cheng Y, Huang H
European journal of pharmacology 2023 May 15;947:175676

Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1.

Yang X, Zhang M, Xie B, Peng Z, Manning JR, Zimmerman R, Wang Q, Wei AC, Khalifa M, Reynolds M, Jin J, Om M, Zhu G, Bedja D, Jiang H, Jurczak M, Shiva S, Scott I, O'Rourke B, Kass DA, Paolocci N, Feng N
Cardiovascular research 2023 Mar 31;119(2):571-586

5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation.

Zong Y, Wang M, Liu Y, Suo X, Fan G, Yang X
Life sciences 2023 Jun 15;323:121703

Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.

Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Sato T, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Yano T, Tanno M, Miki T, Miura T
Physiological reports 2023 Feb;11(4):e15608

Fatty acid β-oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice.

Wang P, Wei R, Cui X, Jiang Z, Yang J, Zu L, Hong T
Journal of diabetes 2023 Dec;15(12):1081-1094

m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.

Wu Z, Zuo X, Zhang W, Li Y, Gui R, Leng J, Shen H, Pan B, Fan L, Li J, Jin H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304895

Maturation of lipid metabolism in the fetal and newborn sheep heart.

Drake RR, Louey S, Thornburg KL
American journal of physiology. Regulatory, integrative and comparative physiology 2023 Dec 1;325(6):R809-R819

Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.

Chapoy Villanueva H, Sung JH, Stevens JA, Zhang MJ, Nelson PM, Denduluri LS, Feng F, O'Connell TD, Townsend D, Liu JC
Journal of molecular and cellular cardiology 2023 Aug;181:33-45

Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice.

Wu ZY, Luo L, Kan YQ, Qin ML, Li HT, He QZ, Zeng HC
Toxics 2023 Aug 26;11(9)

G-protein coupled receptor 19 (GPR19) knockout mice display sex-dependent metabolic dysfunction.

Mushala BAS, Xie B, Sipula IJ, Stoner MW, Thapa D, Manning JR, Bugga P, Vandevender AM, Jurczak MJ, Scott I
Scientific reports 2023 Apr 15;13(1):6134

Maternal High-Fat Diet Impairs Placental Fatty Acid β-Oxidation and Metabolic Homeostasis in the Offspring.

Zhang L, Wang Z, Wu H, Gao Y, Zheng J, Zhang J
Frontiers in nutrition 2022;9:849684

MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following Heart Failure Through Improving the Cardiometabolic Dysfunction in Obese Mice.

Wang M, Zhao M, Yu J, Xu Y, Zhang J, Liu J, Zheng Z, Ye J, Wang Z, Ye D, Feng Y, Xu S, Pan W, Wei C, Wan J
Frontiers in cardiovascular medicine 2022;9:727474

LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.

Fang Y, Dou R, Huang S, Han L, Fu H, Yang C, Song J, Zheng J, Zhang X, Liu K, Xiang Z, Zhang X, Wang S, Xiong B
International journal of biological sciences 2022;18(7):3082-3101

First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.

Zhu WZ, Palazzo T, Zhou M, Ledee D, Olson HM, Paša-Tolić L, Olson AK
PloS one 2022;17(10):e0276285

Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue.

Yoshida Y, Shimizu I, Hsiao YT, Suda M, Katsuumi G, Seki M, Suzuki Y, Okuda S, Soga T, Minamino T
iScience 2022 May 20;25(5):104268

Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.

Tavasoli M, Lahire S, Sokolenko S, Novorolsky R, Reid SA, Lefsay A, Otley MOC, Uaesoontrachoon K, Rowsell J, Srinivassane S, Praest M, MacKinnon A, Mammoliti MS, Maloney AA, Moraca M, Pedro Fernandez-Murray J, McKenna M, Sinal CJ, Nagaraju K, Robertson GS, Hoffman EP, McMaster CR
Nature communications 2022 Mar 23;13(1):1559

Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p.

Lou J, Wu J, Feng M, Dang X, Wu G, Yang H, Wang Y, Li J, Zhao Y, Shi C, Liu J, Zhao L, Zhang X, Gao F
Journal of sport and health science 2022 Jul;11(4):495-508

MicroRNA-377-3p inhibits hepatocellular carcinoma growth and metastasis through negative regulation of CPT1C-mediated fatty acid oxidation.

Zhang T, Zhang Y, Liu J, Ma Y, Ye Q, Yan X, Ding L
Cancer & metabolism 2022 Jan 20;10(1):2

Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart.

Drake RR, Louey S, Thornburg KL
The Journal of physiology 2022 Feb;600(3):655-670

A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis.

Peng H, Hu B, Xie LQ, Su T, Li CJ, Liu Y, Yang M, Xiao Y, Feng X, Zhou R, Guo Q, Zhou HY, Huang Y, Jiang TJ, Luo XH
Cell metabolism 2022 Aug 2;34(8):1168-1182.e6

The Protective Effect of 1,25(OH)(2)D(3) on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism.

Yang J, Zhang Y, Pan Y, Sun C, Liu Z, Liu N, Fu Y, Li X, Li Y, Kong J
Frontiers in cell and developmental biology 2021;9:627135

FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.

Zhuang L, Mao Y, Liu Z, Li C, Jin Q, Lu L, Tao R, Yan X, Chen K
Frontiers in cardiovascular medicine 2021;8:722908

Enhancing Fatty Acids Oxidation via L-Carnitine Attenuates Obesity-Related Atrial Fibrillation and Structural Remodeling by Activating AMPK Signaling and Alleviating Cardiac Lipotoxicity.

Zhang Y, Fu Y, Jiang T, Liu B, Sun H, Zhang Y, Fan B, Li X, Qin X, Zheng Q
Frontiers in pharmacology 2021;12:771940

Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR-α Signaling Pathway Improving Energy Metabolism.

Zhang X, Zhang Z, Wang P, Han Y, Liu L, Li J, Chen Y, Liu D, Wang J, Tian X, Zhao Q, Yan F
Frontiers in pharmacology 2021;12:653901

PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes.

Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L
Cell reports 2021 Oct 5;37(1):109767

Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.

Wang T, Hu W, Niu Y, Liu S, Fu L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330

LEFTY-PITX2 signaling pathway is critical for generation of mature and ventricular cardiac organoids in human pluripotent stem cell-derived cardiac mesoderm cells.

Song MH, Choi SC, Noh JM, Joo HJ, Park CY, Cha JJ, Ahn TH, Ko TH, Choi JI, Na JE, Rhyu IJ, Jang Y, Park Y, Gim JA, Kim JH, Lim DS
Biomaterials 2021 Nov;278:121133

Short-term but not long-term high fat diet feeding protects against pressure overload-induced heart failure through activation of mitophagy.

Tan Y, Li M, Wu G, Lou J, Feng M, Xu J, Zhou J, Zhang P, Yang H, Dong L, Li J, Zhang X, Gao F
Life sciences 2021 May 1;272:119242

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle.

Huang TY, Linden MA, Fuller SE, Goldsmith FR, Simon J, Batdorf HM, Scott MC, Essajee NM, Brown JM, Noland RC
American journal of physiology. Endocrinology and metabolism 2021 Jun 1;320(6):E1053-E1067

Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t-TUCB on Diet-Induced Obesity in Mice.

Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L
International journal of molecular sciences 2021 Jul 31;22(15)

Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy.

Kim D, Wu Y, Li Q, Oh YK
Nano-micro letters 2021 Jan 4;13(1):31

Aging Influences the Metabolic and Inflammatory Phenotype in an Experimental Mouse Model of Acute Lung Injury.

Gibbs KW, Chuang Key CC, Belfield L, Krall J, Purcell L, Liu C, Files DC
The journals of gerontology. Series A, Biological sciences and medical sciences 2021 Apr 30;76(5):770-777

Targeting CPT1B as a potential therapeutic strategy in castration-resistant and enzalutamide-resistant prostate cancer.

Abudurexiti M, Zhu W, Wang Y, Wang J, Xu W, Huang Y, Zhu Y, Shi G, Zhang H, Zhu Y, Shen Y, Dai B, Wan F, Lin G, Ye D
The Prostate 2020 Sep;80(12):950-961

Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish.

Li LY, Lv HB, Jiang ZY, Qiao F, Chen LQ, Zhang ML, Du ZY
The Journal of physiology 2020 Oct;598(20):4537-4553

LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1.

Gui W, Zhu WF, Zhu Y, Tang S, Zheng F, Yin X, Lin X, Li H
Cell communication and signaling : CCS 2020 Oct 28;18(1):173

Modulation of Fatty Acid-Related Genes in the Response of H9c2 Cardiac Cells to Palmitate and n-3 Polyunsaturated Fatty Acids.

Cetrullo S, D'Adamo S, Panichi V, Borzì RM, Pignatti C, Flamigni F
Cells 2020 Feb 26;9(3)

Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.

Wang Y, Yin C, Chen Z, Li Y, Zou Y, Wang X, An Y, Wu F, Zhang G, Yang C, Tang H, Zou Y, Gong H
Cell and tissue research 2020 Apr;380(1):143-153

Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice.

Xu W, Zhou H, Xuan H, Saha P, Wang G, Chen W
Molecular and cellular endocrinology 2019 Feb 15;482:1-10

PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.

Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov LN, Zhang X, Ma H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.

Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ
Cell metabolism 2017 Sep 5;26(3):509-522.e6

TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling.

Chen J, Young ME, Chatham JC, Crossman DK, Dell'Italia LJ, Shalev A
American journal of physiology. Heart and circulatory physiology 2016 Jul 1;311(1):H64-75

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CPT1B-specific antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CPT1B-specific. This antibody recognizes human, mouse antigen. The CPT1B-specific antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 22170-1-AP.pdf

: Show more