BS60061

antibody from Bioworld Technology, Inc
Targeting: CIB1 CIB, KIP, SIP2-28
Provider product page for BS60061

Antibody data

Product number
BS60061 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CIB1 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human CIB1.
Description
Platelets regulate the function of Integrin Ï«2b/ÉÇ3 (GPIIb/IIIa), the platelet Fibrinogen receptor, which is involved in the binding of proteins to integrin cytoplasmic domains. A novel protein, CIB, for calcium- and integrin-binding protein (also designated as Kip for kinase interacting protein, SIP2-28 and DNA-PKcs interacting protein), binds specifically at the cytoplasmic domain of Ï«2b by a number of positively charged residues in its binding site. Binding of CIB to the Ï«2b is affected by fluctuations in the intracellular calcium concentration. In aggregated platelets, endogenous CIB and Ï«2b/ÉÇ3 translocate to the Triton X-100-insoluble cytoskeleton, demonstrating that the cellular localization of CIB is regulated. CIB also binds to DNA-PKcs, which is a nu-clear protein serine/threonine kinase that plays a role in the DNA repair and recombination process of lymphoid development. Fnk also binds to the CIB, suggesting that CIB may be a regulatory subunit of polo-like kinases. CIB shows significant homology to calcineurin B and calmodulin, and its mRNA levels are ubiquitously expressed in various human tissues.
Reactivity
Human, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CIB1 protein structure - BS60061 shown in red.