HLA-DOA

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

Description

Major histocompatibility complex, class II, DO alpha

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (33004182 - 33009591)

Ensembl ID

ENSG00000204252  (ver. 103.38)

Orthologs

Mouse H2-Oa: ENSMUSG00000024334

UniProt

P06340

neXtProt

NX_P06340

Human splice variants
Mouse splice variants

Protein structure