BS3134

antibody from Bioworld Technology, Inc

Targeting: HLA-DOA HLA-D0-alpha, HLA-DNA, HLA-DZA

Immunohistochemistry

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Validation data

Product number: BS3134 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS3134, RRID:AB_1914317
Product name: HLA DOÏ« (V111) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 81-130 of Human HLA-DOÏ«.
Description: Reacts with HLA-DO, a heterodimer formed by DNÏ« and DOÉÇ subunits in B cells. DNÏ« and DOÉÇ are the products of the non-classical class II genes, HLA-DNA and HLA-DOB, respectively. DO forms tight complexes with DM in the endoplasmic reticulum and is thereby sorted to lysosomal vesicles during antigen processing and presentation. It is tightly associated with DM and it is selectively expressed on antigen-presenting cells, such as B cells, dendritic cells and thymic epithelial cells. DO can enhance the efficiency of peptide loading and has been found to stabilize DM at low pH, preserving its chaperon activity. DO-DM complexes are more efficient than DM in protecting empty DR molecules. Reports describe DO as a co-chaperone of DM. This antibody has also been reported to be suitable for western blot and immunoprecipitation.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

HLA-DOA protein structure - BS3134 shown in red.