BS7797

antibody from Bioworld Technology, Inc
Targeting: NKX2-5 CSX, CSX1, NKX2.5, NKX2E, NKX4-1
Provider product page for BS7797
Western blot
Immunohistochemistry

Antibody data

Product number
BS7797 - Provider product page
Provider
Bioworld Technology, Inc
Product name
NKX2 5 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human NKX2-5.
Description
Nkx-2.5, which is also designated cardiac specific homeobox protein (Csx), is a homeodomain-containing nuclear transcription protein of the Nkx-2 gene family. These transcriptional activators, which include thyroid transcription factor-1 (TTF-1), regulate the expression of tissue specific genes and are required for maintaining the differentiated phenotypes of various lineages. Nkx-2.5 is a homolog to the tinman protein expressed in Drosophila, and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. During embryonic development, Nkx-2.5 is also expressed in the foregut, thyroid, spleen and stomach, while in the adult expression is predominantly restricted to the heart. Mutations that disrupt Nkx-2.5 can result in atrial-septal defects, embryonic lethality and congenital heart disease.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NKX2-5 protein structure - BS7797 shown in red.