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Learn12172-1-AP
antibody from Proteintech Group
Targeting: FKBP10
FKBP6, FKBP65, FLJ20683, FLJ22041, FLJ23833, hFKBP65
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12172-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12172-1-AP, RRID:AB_2102550
- Product name
- FKBP65 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FKBP65 antibody (Cat. #12172-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Melanoma-intrinsic NR2F6 activity regulates antitumor immunity.
Clinical features and molecular characterization of Chinese patients with FKBP10 variants.
Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes.
Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis?
Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta.
Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.
FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.
IFT20 is critical for collagen biosynthesis in craniofacial bone formation.
Cyclophilin B control of lysine post-translational modifications of skin type I collagen.
Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone.
A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen.
FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2.
HSP47 and FKBP65 cooperate in the synthesis of type I procollagen.
Connective tissue alterations in Fkbp10-/- mice.
Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.
Endoplasmic reticulum stress or mutation of an EF-hand Ca(2+)-binding domain directs the FKBP65 rotamase to an ERAD-based proteolysis.
Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA
Science advances 2023 Jul 7;9(27):eadf6621
Science advances 2023 Jul 7;9(27):eadf6621
Clinical features and molecular characterization of Chinese patients with FKBP10 variants.
Tan Z, Shek HT, Chen P, Dong Z, Zhou Y, Yin S, Qiu A, Dong L, Gao B, To MKT
Molecular genetics & genomic medicine 2023 Apr;11(4):e2122
Molecular genetics & genomic medicine 2023 Apr;11(4):e2122
Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes.
Terajima M, Taga Y, Nakamura T, Guo HF, Kayashima Y, Maeda-Smithies N, Parag-Sharma K, Kim JS, Amelio AL, Mizuno K, Kurie JM, Yamauchi M
Scientific reports 2022 Aug 22;12(1):14256
Scientific reports 2022 Aug 22;12(1):14256
Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices: A Surprising Lack of Effects on Fibrogenesis?
Ruigrok MJR, El Amasi KEM, Leeming DJ, Sand JMB, Frijlink HW, Hinrichs WLJ, Olinga P
Frontiers in medicine 2021;8:607962
Frontiers in medicine 2021;8:607962
Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta.
Lim J, Lietman C, Grol MW, Castellon A, Dawson B, Adeyeye M, Rai J, Weis M, Keene DR, Schweitzer R, Park D, Eyre DR, Krakow D, Lee BH
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 22;118(25)
Identification of signal peptide features for substrate specificity in human Sec62/Sec63-dependent ER protein import.
Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V, Zimmermann R
The FEBS journal 2020 Nov;287(21):4612-4640
The FEBS journal 2020 Nov;287(21):4612-4640
FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth.
Ramadori G, Ioris RM, Villanyi Z, Firnkes R, Panasenko OO, Allen G, Konstantinidou G, Aras E, Brenachot X, Biscotti T, Charollais A, Luchetti M, Bezrukov F, Santinelli A, Samad M, Baldi P, Collart MA, Coppari R
Cell reports 2020 Mar 17;30(11):3851-3863.e6
Cell reports 2020 Mar 17;30(11):3851-3863.e6
IFT20 is critical for collagen biosynthesis in craniofacial bone formation.
Yamaguchi H, Terajima M, Kitami M, Wang J, He L, Saeki M, Yamauchi M, Komatsu Y
Biochemical and biophysical research communications 2020 Dec 17;533(4):739-744
Biochemical and biophysical research communications 2020 Dec 17;533(4):739-744
Cyclophilin B control of lysine post-translational modifications of skin type I collagen.
Terajima M, Taga Y, Cabral WA, Liu Y, Nagasawa M, Sumida N, Kayashima Y, Chandrasekaran P, Han L, Maeda N, Perdivara I, Hattori S, Marini JC, Yamauchi M
PLoS genetics 2019 Jun;15(6):e1008196
PLoS genetics 2019 Jun;15(6):e1008196
Heat shock protein 47 and 65-kDa FK506-binding protein weakly but synergistically interact during collagen folding in the endoplasmic reticulum.
Ishikawa Y, Holden P, Bächinger HP
The Journal of biological chemistry 2017 Oct 20;292(42):17216-17224
The Journal of biological chemistry 2017 Oct 20;292(42):17216-17224
Fkbp10 Deletion in Osteoblasts Leads to Qualitative Defects in Bone.
Lietman CD, Lim J, Grafe I, Chen Y, Ding H, Bi X, Ambrose CG, Fratzl-Zelman N, Roschger P, Klaushofer K, Wagermaier W, Schmidt I, Fratzl P, Rai J, Weis M, Eyre D, Keene DR, Krakow D, Lee BH
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Jun;32(6):1354-1367
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Jun;32(6):1354-1367
A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen.
Duran I, Martin JH, Weis MA, Krejci P, Konik P, Li B, Alanay Y, Lietman C, Lee B, Eyre D, Cohn DH, Krakow D
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Jun;32(6):1309-1319
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Jun;32(6):1309-1319
FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.
Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, Yamauchi M, Kurie JM
Scientific reports 2017 Apr 5;7:46021
Scientific reports 2017 Apr 5;7:46021
Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2.
Gjaltema RA, van der Stoel MM, Boersema M, Bank RA
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7142-7
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7142-7
HSP47 and FKBP65 cooperate in the synthesis of type I procollagen.
Duran I, Nevarez L, Sarukhanov A, Wu S, Lee K, Krejci P, Weis M, Eyre D, Krakow D, Cohn DH
Human molecular genetics 2015 Apr 1;24(7):1918-28
Human molecular genetics 2015 Apr 1;24(7):1918-28
Connective tissue alterations in Fkbp10-/- mice.
Lietman CD, Rajagopal A, Homan EP, Munivez E, Jiang MM, Bertin TK, Chen Y, Hicks J, Weis M, Eyre D, Lee B, Krakow D
Human molecular genetics 2014 Sep 15;23(18):4822-31
Human molecular genetics 2014 Sep 15;23(18):4822-31
Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging.
Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY
Molecular cell 2014 Jul 17;55(2):332-41
Molecular cell 2014 Jul 17;55(2):332-41
Endoplasmic reticulum stress or mutation of an EF-hand Ca(2+)-binding domain directs the FKBP65 rotamase to an ERAD-based proteolysis.
Murphy LA, Ramirez EA, Trinh VT, Herman AM, Anderson VC, Brewster JL
Cell stress & chaperones 2011 Nov;16(6):607-19
Cell stress & chaperones 2011 Nov;16(6):607-19
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 12172-1-AP( FKBP10 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FKBP10 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FKBP10. This antibody recognizes human,mouse,rat antigen. The FKBP10 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
