Tissue expression
Cell line expression
SORBS2
gene productARGBP2, KIAA0777
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Description
- Sorbin and SH3 domain containing 2
- Tissue specificity
- Tissue enhanced (heart muscle, thyroid gland)
- Predicted location
- Intracellular
- Protein family
- Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
- Chromosome
- 4:q35.1 (185585444 - 185956652)
- Ensembl ID
- ENSG00000154556 (ver. 103.38)
- Orthologs
- Mouse Sorbs2: ENSMUSG00000031626
- UniProt
- O94875
- neXtProt
- NX_O94875
Human splice variants
Mouse splice variants
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.
Featured antibodies
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0 references | Polyclonal |
ICC
IHC |