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antibody from Novus Biologicals
Targeting: TGFBR1
ACVRLK4, ALK-5, ALK5, ESS1, MSSE, TBR-i, TBRI
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- AF3025 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal TGF-beta RI/ALK-5 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human TGF-beta RI/ALK-5 in direct ELISAs and Western blots. In direct ELISAs, less than 25% cross-reactivity with recombinant mouse TGF-beta RI is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.
MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.
Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension.
MiR-142-3p represses TGF-β-induced growth inhibition through repression of TGFβR1 in non-small cell lung cancer.
Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells.
Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta.
Wang B, Xu X, Yang Z, Zhang L, Liu Y, Ma A, Xu G, Tang M, Jing T, Wu L, Liu Y
EBioMedicine 2019 Mar;41:320-332
EBioMedicine 2019 Mar;41:320-332
MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.
Chen Y, Wang DD, Wu YP, Su D, Zhou TY, Gai RH, Fu YY, Zheng L, He QJ, Zhu H, Yang B
British journal of cancer 2017 Oct 10;117(8):1192-1201
British journal of cancer 2017 Oct 10;117(8):1192-1201
Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension.
Gore B, Izikki M, Mercier O, Dewachter L, Fadel E, Humbert M, Dartevelle P, Simonneau G, Naeije R, Lebrin F, Eddahibi S
PloS one 2014;9(6):e100310
PloS one 2014;9(6):e100310
MiR-142-3p represses TGF-β-induced growth inhibition through repression of TGFβR1 in non-small cell lung cancer.
Lei Z, Xu G, Wang L, Yang H, Liu X, Zhao J, Zhang HT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2696-704
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jun;28(6):2696-704
Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells.
Yao Y, Zebboudj AF, Torres A, Shao E, Boström K
Cardiovascular research 2007 May 1;74(2):279-89
Cardiovascular research 2007 May 1;74(2):279-89
Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta.
Haynes LP, Fitzgerald DJ, Wareing B, O'Callaghan DW, Morgan A, Burgoyne RD
Proteomics 2006 Mar;6(6):1822-32
Proteomics 2006 Mar;6(6):1822-32
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human TGF‑ß RI/ALK‑5 by Western Blot. Detection of Human TGF‑ß RI/ALK‑5 by Western Blot.
