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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Western blot [3]
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- Product number
- H00023197-B01 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#H00023197-B01, RRID:AB_1116041
- Product name
- UBXD8 MaxPab mouse polyclonal antibody (B01)
- Antibody type
- Polyclonal
- Description
- Mouse polyclonal antibody raised against a full-length human UBXD8 protein.
- Antigen sequence
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHT
LEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQ
VNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRF
TYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFM
HSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLV
YLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWA
CSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTV
VGRLEGLIQPDDLINQLTFIMDANQTYLVSERLER
EERNQTQVLRQQQDEAYLASLRADQEKERKKREER
ERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECL
PPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLT
VIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEW
PNPPTLQEAGLSHTEVLFVQDLTDE- Storage
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Submitted references Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.
Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.
Jo Y, Hartman IZ, DeBose-Boyd RA
Molecular biology of the cell 2013 Feb;24(3):169-83
Molecular biology of the cell 2013 Feb;24(3):169-83
Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA
Proceedings of the National Academy of Sciences of the United States of America 2011 Dec 20;108(51):20503-8
Proceedings of the National Academy of Sciences of the United States of America 2011 Dec 20;108(51):20503-8
Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.
Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J
The Journal of biological chemistry 2008 Nov 28;283(48):33772-83
The Journal of biological chemistry 2008 Nov 28;283(48):33772-83
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western Blot analysis of FAF2 expression in transfected 293T cell line (H00023197-T01) by FAF2 MaxPab polyclonal antibody.Lane 1: UBXD8 transfected lysate(48.95 KDa).Lane 2: Non-transfected lysate.
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- UBXD8 MaxPab polyclonal antibody. Western Blot analysis of UBXD8 expression in rat brain.
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- FAF2 MaxPab polyclonal antibody. Western Blot analysis of FAF2 expression in Jurkat.
