FNab07722

antibody from FineTest Biotech
Targeting: SEPTIN2 DIFF6, hNedd5, KIAA0158, NEDD5, Pnutl3, SEPT2
Provider product page for FNab07722
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
FNab07722 - Provider product page
Provider
FineTest Biotech
Product name
SEPT2 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex(also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
septin 2
Epitope
IgG1
Isotype
IgG
Antibody clone number
8H4
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
SEPTIN2 protein structure - FNab07722 shown in red.