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- References [214]
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- Western blot [1]
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- Product number
- 10638-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10638-1-AP, RRID:AB_2245711
- Product name
- REDD1 specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated REDD1 specific antibody (Cat. #10638-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation.
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition.
REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression.
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.
REDD1 attenuates hepatic stellate cell activation and liver fibrosis via inhibiting of TGF-β/Smad signaling pathway.
Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models.
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease.
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation.
Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies.
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.
Effect of hypoxic exercise on glucose tolerance in healthy and prediabetic adults.
TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression.
Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription.
CDK7 blockade suppresses super-enhancer-associated oncogenes in bladder cancer.
RTP801 regulates motor cortex synaptic transmission and learning.
Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology.
A clinically relevant decrease in contractile force differentially regulates control of glucocorticoid receptor translocation in mouse skeletal muscle.
Treatment of ErbB2 breast cancer by mitochondrial targeting.
Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development.
A Novel Approach to Safer Glucocorticoid Receptor-Targeted Anti-lymphoma Therapy via REDD1 (Regulated in Development and DNA Damage 1) Inhibition.
PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.
Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle-Dependent Dermal Adipose Expansion.
GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice.
The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.
MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease.
AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions.
REDD1 overexpression in oral squamous cell carcinoma may predict poor prognosis and correlates with high microvessel density.
Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin.
REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet.
Increased REDD1 facilitates neuronal damage after subarachnoid hemorrhage.
Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice.
Endurance exercise decreases protein synthesis and ER-mitochondria contacts in mouse skeletal muscle.
REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice.
Selenium supplementation suppresses immunological and serological features of lupus in B6.Sle1b mice.
PI3K inhibitors protect against glucocorticoid-induced skin atrophy.
The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma.
Hypoxia-induced regulation of mTOR signaling by miR-7 targeting REDD1.
Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury.
Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli.
Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye.
Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1.
Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway.
Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy.
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.
Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle.
Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy.
Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress.
Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma.
Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation.
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia.
Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation.
Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes.
MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells.
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activation.
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes.
Gestational Protein Restriction in Wistar Rats; Effect of Taurine Supplementation on Properties of Newborn Skeletal Muscle.
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.
Relationship between exercise volume and muscle protein synthesis in a rat model of resistance exercise.
Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression.
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.
Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis.
RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4-Dependent Oxidative Stress Induced by Cigarette Smoke.
Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Neuromuscular Electrical Stimulation Combined with Protein Ingestion Preserves Thigh Muscle Mass But Not Muscle Function in Healthy Older Adults During 5 Days of Bed Rest.
REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.
Implication of REDD1 in the activation of inflammatory pathways.
Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis.
Time-Course Change of Redd1 Expressions in the Hippocampal CA1 Region Following Chronic Cerebral Hypoperfusion.
Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts.
Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle.
Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of rapamycin in human placental BeWo cells under hypoxia.
Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue.
Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy.
Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease.
Loss of REDD1 augments the rate of the overload-induced increase in muscle mass.
Hypoxia-induced regulation of placental REDD1 and mTOR was impaired in a rat model of estrogen-induced cholestasis.
DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling.
Acute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice Is REDD-1 and mTOR-Independent.
Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1.
Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells.
C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion.
Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging.
RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.
Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells.
Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis and intracellular signalling in young males.
Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle.
Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity.
Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum.
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling.
Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury.
REDD1 Is Essential for Optimal T Cell Proliferation and Survival.
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.
Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages.
Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801.
Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.
Moderate alcohol consumption does not impair overload-induced muscle hypertrophy and protein synthesis.
Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.
REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.
Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction.
Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer.
Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents.
Sepsis attenuates the anabolic response to skeletal muscle contraction.
REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.
Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.
ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.
Effects of Salidroside on cobalt chloride-induced hypoxia damage and mTOR signaling repression in PC12 cells.
Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy.
Changes and expressions of Redd1 in neurons and glial cells in the gerbil hippocampus proper following transient global cerebral ischemia.
Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway.
Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling.
Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.
Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.
REDD1 attenuates cardiac hypertrophy via enhancing autophagy.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.
Ambient hypoxia enhances the loss of muscle mass after extensive injury.
Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines.
REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.
Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.
Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle.
Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.
Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.
Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia.
Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling.
Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner.
mTORC1 dependent regulation of REDD1 protein stability.
Zoledronic acid-induced cytotoxicity through endoplasmic reticulum stress triggered REDD1-mTOR pathway in breast cancer cells.
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids.
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues.
Post-translational regulation of mTOR complex 1 in hypoxia and reoxygenation.
Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway.
Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma.
FIP200 regulates targeting of Atg16L1 to the isolation membrane.
Salidroside protects against hydrogen peroxide-induced injury in HUVECs via the regulation of REDD1 and mTOR activation.
Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer.
RTP801 is required for ceramide-induced cell-specific death in the murine lung.
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation.
Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins.
Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).
Sustained overexpression of Redd1 leads to Akt activation involved in cell survival.
REDD1 protects osteoblast cells from gamma radiation-induced premature senescence.
Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes.
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
REDD1 expression in placenta during human gestation.
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs.
Hypoxia transiently affects skeletal muscle hypertrophy in a functional overload model.
Retina expression and cross-species validation of gene silencing by PF-655, a small interfering RNA against RTP801 for the treatment of ocular disease.
eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells.
Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy.
Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells.
Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.
TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.
RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration.
AMPK regulates metabolism and survival in response to ionizing radiation.
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle.
Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.
Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation.
A novel cardioprotective p38-MAPK/mTOR pathway.
Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
Redd1 inhibits the invasiveness of non-small cell lung cancer cells.
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.
REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss.
Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.
miR-221 overexpression contributes to liver tumorigenesis.
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.
Plzf regulates germline progenitor self-renewal by opposing mTORC1.
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling.
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress.
Glucocorticoid-mediated repression of REDD1 mRNA expression in rat fetal distal lung epithelial cells.
The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.
REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells.
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling.
SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression.
Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G(1) phase cell cycle arrest.
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes.
REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis.
Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress.
Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft.
Acute alcohol intoxication increases REDD1 in skeletal muscle.
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.
RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation.
Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.
Tang H, Tan C, Cao X, Liu Y, Zhao H, Liu Y, Zhao Y
Frontiers in medicine 2021;8:692781
Frontiers in medicine 2021;8:692781
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition.
Han S, Zhu L, Zhu Y, Meng Y, Li J, Song P, Yousafzai NA, Feng L, Chen M, Wang Y, Jin H, Wang X
Theranostics 2021;11(17):8464-8479
Theranostics 2021;11(17):8464-8479
REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression.
Park M, Kim J, Kim T, Kim S, Park W, Ha KS, Cho SH, Won MH, Lee JH, Kwon YG, Kim YM
Experimental & molecular medicine 2021 Oct;53(10):1612-1622
Experimental & molecular medicine 2021 Oct;53(10):1612-1622
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Feng Y, Cao X, Zhao B, Song C, Pang B, Hu L, Zhang C, Wang J, He J, Wang S
Science China. Life sciences 2021 Nov;64(11):1814-1828
Science China. Life sciences 2021 Nov;64(11):1814-1828
m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.
Qin Y, Li B, Arumugam S, Lu Q, Mankash SM, Li J, Sun B, Li J, Flavell RA, Li HB, Ouyang X
Cell reports 2021 Nov 9;37(6):109968
Cell reports 2021 Nov 9;37(6):109968
REDD1 attenuates hepatic stellate cell activation and liver fibrosis via inhibiting of TGF-β/Smad signaling pathway.
Cho SS, Lee JH, Kim KM, Park EY, Ku SK, Cho IJ, Yang JH, Ki SH
Free radical biology & medicine 2021 Nov 20;176:246-256
Free radical biology & medicine 2021 Nov 20;176:246-256
Myod1 and GR coordinate myofiber-specific transcriptional enhancers.
Rovito D, Rerra AI, Ueberschlag-Pitiot V, Joshi S, Karasu N, Dacleu-Siewe V, Rayana KB, Ghaibour K, Parisotto M, Ferry A, Jelinsky SA, Laverny G, Klaholz BP, Sexton T, Billas IML, Duteil D, Metzger D
Nucleic acids research 2021 May 7;49(8):4472-4492
Nucleic acids research 2021 May 7;49(8):4472-4492
An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models.
Niu M, Li L, Su Z, Wei L, Pu W, Zhao C, Ding Y, Wazir J, Cao W, Song S, Gao Q, Wang H
Cell death & disease 2021 Jun 26;12(7):652
Cell death & disease 2021 Jun 26;12(7):652
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease.
Pérez-Sisqués L, Sancho-Balsells A, Solana-Balaguer J, Campoy-Campos G, Vives-Isern M, Soler-Palazón F, Anglada-Huguet M, López-Toledano MÁ, Mandelkow EM, Alberch J, Giralt A, Malagelada C
Cell death & disease 2021 Jun 15;12(6):616
Cell death & disease 2021 Jun 15;12(6):616
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Jang SK, Hong SE, Lee DH, Kim JY, Kim JY, Ye SK, Hong J, Park IC, Jin HO
BMC cancer 2021 Jul 12;21(1):803
BMC cancer 2021 Jul 12;21(1):803
Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation.
Xu SH, Fu WW, Zhang J, Wang HP, Dang K, Chang H, Gao YF
The Journal of experimental biology 2021 Jan 18;224(Pt 2)
The Journal of experimental biology 2021 Jan 18;224(Pt 2)
Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies.
Jaune E, Cavazza E, Ronco C, Grytsai O, Abbe P, Tekaya N, Zerhouni M, Beranger G, Kaminski L, Bost F, Gesson M, Tulic M, Hofman P, Ballotti R, Passeron T, Botton T, Benhida R, Rocchi S
Cell death & disease 2021 Jan 11;12(1):64
Cell death & disease 2021 Jan 11;12(1):64
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression.
Kon N, Ou Y, Wang SJ, Li H, Rustgi AK, Gu W
Genes & development 2021 Jan 1;35(1-2):59-64
Genes & development 2021 Jan 1;35(1-2):59-64
Effect of hypoxic exercise on glucose tolerance in healthy and prediabetic adults.
De Groote E, Britto FA, Balan E, Warnier G, Thissen JP, Nielens H, Sylow L, Deldicque L
American journal of physiology. Endocrinology and metabolism 2021 Jan 1;320(1):E43-E54
American journal of physiology. Endocrinology and metabolism 2021 Jan 1;320(1):E43-E54
TRIP4 transcriptionally activates DDIT4 and subsequent mTOR signaling to promote glioma progression.
Li W, Hu S, Tian C, Wan X, Yu W, Guo P, Zhao F, Hua C, Lu X, Xue G, Han S, Guo W, Wang D, Deng W
Free radical biology & medicine 2021 Dec;177:31-47
Free radical biology & medicine 2021 Dec;177:31-47
Autism risk gene KMT5B deficiency in prefrontal cortex induces synaptic dysfunction and social deficits via alterations of DNA repair and gene transcription.
Wang ZJ, Rein B, Zhong P, Williams J, Cao Q, Yang F, Zhang F, Ma K, Yan Z
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Aug;46(9):1617-1626
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2021 Aug;46(9):1617-1626
CDK7 blockade suppresses super-enhancer-associated oncogenes in bladder cancer.
Yang Y, Jiang D, Zhou Z, Xiong H, Yang X, Peng G, Xia W, Wang S, Lei H, Zhao J, Qian Z, Wu S, Pang J
Cellular oncology (Dordrecht) 2021 Aug;44(4):871-887
Cellular oncology (Dordrecht) 2021 Aug;44(4):871-887
RTP801 regulates motor cortex synaptic transmission and learning.
Pérez-Sisqués L, Martín-Flores N, Masana M, Solana-Balaguer J, Llobet A, Romaní-Aumedes J, Canal M, Campoy-Campos G, García-García E, Sánchez-Fernández N, Fernández-García S, Gilbert JP, Rodríguez MJ, Man HY, Feinstein E, Williamson DL, Soto D, Gasull X, Alberch J, Malagelada C
Experimental neurology 2021 Aug;342:113755
Experimental neurology 2021 Aug;342:113755
Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology.
Stergiou IE, Kambas K, Poulaki A, Giannouli S, Katsila T, Dimitrakopoulou A, Vidali V, Mouchtouris V, Kloukina I, Xingi E, Pagakis SN, Probert L, Patrinos GP, Ritis K, Tzioufas AG, Voulgarelis M
International journal of molecular sciences 2021 Apr 15;22(8)
International journal of molecular sciences 2021 Apr 15;22(8)
A clinically relevant decrease in contractile force differentially regulates control of glucocorticoid receptor translocation in mouse skeletal muscle.
Dunlap KR, Steiner JL, Rossetti ML, Kimball SR, Gordon BS
Journal of applied physiology (Bethesda, Md. : 1985) 2021 Apr 1;130(4):1052-1063
Journal of applied physiology (Bethesda, Md. : 1985) 2021 Apr 1;130(4):1052-1063
Treatment of ErbB2 breast cancer by mitochondrial targeting.
Eldad S, Hertz R, Vainer G, Saada A, Bar-Tana J
Cancer & metabolism 2020;8:17
Cancer & metabolism 2020;8:17
Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development.
Varela-Guruceaga M, Belaidi E, Lebeau L, Aka E, Andriantsitohaina R, Giorgetti-Peraldi S, Arnaud C, Le Lay S
Frontiers in physiology 2020;11:565486
Frontiers in physiology 2020;11:565486
A Novel Approach to Safer Glucocorticoid Receptor-Targeted Anti-lymphoma Therapy via REDD1 (Regulated in Development and DNA Damage 1) Inhibition.
Lesovaya EA, Savinkova AV, Morozova OV, Lylova ES, Zhidkova EM, Kulikov EP, Kirsanov KI, Klopot A, Baida G, Yakubovskaya MG, Gordon LI, Readhead B, Dudley JT, Budunova I
Molecular cancer therapeutics 2020 Sep;19(9):1898-1908
Molecular cancer therapeutics 2020 Sep;19(9):1898-1908
PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
Lim JT, Singh N, Leuvano LA, Calvert VS, Petricoin EF, Teachey DT, Lock RB, Padi M, Kraft AS, Padi SKR
Molecular cancer therapeutics 2020 Sep;19(9):1809-1821
Molecular cancer therapeutics 2020 Sep;19(9):1809-1821
H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.
Kim Y, Stahl MC, Huang X, Connor JR
Journal of neurochemistry 2020 Sep;155(2):177-190
Journal of neurochemistry 2020 Sep;155(2):177-190
Regulated in Development and DNA Damage Responses 1 Prevents Dermal Adipocyte Differentiation and Is Required for Hair Cycle-Dependent Dermal Adipose Expansion.
Rivera-Gonzalez GC, Klopot A, Sabin K, Baida G, Horsley V, Budunova I
The Journal of investigative dermatology 2020 Sep;140(9):1698-1705.e1
The Journal of investigative dermatology 2020 Sep;140(9):1698-1705.e1
GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y
JCI insight 2020 May 7;5(9)
JCI insight 2020 May 7;5(9)
Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice.
Deguchi H, Ikeda M, Ide T, Tadokoro T, Ikeda S, Okabe K, Ishikita A, Saku K, Matsushima S, Tsutsui H
Circulation journal : official journal of the Japanese Circulation Society 2020 May 25;84(6):1028-1033
Circulation journal : official journal of the Japanese Circulation Society 2020 May 25;84(6):1028-1033
The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.
Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y
Cell death and differentiation 2020 Mar;27(3):1119-1133
Cell death and differentiation 2020 Mar;27(3):1119-1133
MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
Nath SR, Lieberman ML, Yu Z, Marchioretti C, Jones ST, Danby ECE, Van Pelt KM, Sorarù G, Robins DM, Bates GP, Pennuto M, Lieberman AP
Acta neuropathologica 2020 Jul;140(1):63-80
Acta neuropathologica 2020 Jul;140(1):63-80
Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease.
Martín-Flores N, Pérez-Sisqués L, Creus-Muncunill J, Masana M, Ginés S, Alberch J, Pérez-Navarro E, Malagelada C
Cell death & disease 2020 Jul 30;11(7):569
Cell death & disease 2020 Jul 30;11(7):569
AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions.
Bouquier N, Moutin E, Tintignac LA, Reverbel A, Jublanc E, Sinnreich M, Chastagnier Y, Averous J, Fafournoux P, Verpelli C, Boeckers T, Carnac G, Perroy J, Ollendorff V
BMC biology 2020 Jul 3;18(1):81
BMC biology 2020 Jul 3;18(1):81
REDD1 overexpression in oral squamous cell carcinoma may predict poor prognosis and correlates with high microvessel density.
Feng Y, Song K, Shang W, Chen L, Wang C, Pang B, Wang N
Oncology letters 2020 Jan;19(1):431-441
Oncology letters 2020 Jan;19(1):431-441
Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin.
Baida G, Agarwal S, Readhead B, Dudley JT, Budunova I
Oncotarget 2020 Jan 28;11(4):409-418
Oncotarget 2020 Jan 28;11(4):409-418
REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet.
Dumas K, Ayachi C, Gilleron J, Lacas-Gervais S, Pastor F, Favier FB, Peraldi P, Vaillant N, Yvan-Charvet L, Bonnafous S, Patouraux S, Anty R, Tran A, Gual P, Cormont M, Tanti JF, Giorgetti-Peraldi S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5046-5060
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5046-5060
Increased REDD1 facilitates neuronal damage after subarachnoid hemorrhage.
Su J, Wang M, Yan Y, Ju S, Chen J, Wu X
Neurochemistry international 2019 Sep;128:14-20
Neurochemistry international 2019 Sep;128:14-20
Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice.
McCrary MR, Jiang MQ, Giddens MM, Zhang JY, Owino S, Wei ZZ, Zhong W, Gu X, Xin H, Hall RA, Wei L, Yu SP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Oct;33(10):10680-10691
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Oct;33(10):10680-10691
Endurance exercise decreases protein synthesis and ER-mitochondria contacts in mouse skeletal muscle.
Merle A, Jollet M, Britto FA, Goustard B, Bendridi N, Rieusset J, Ollendorff V, Favier FB
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Nov 1;127(5):1297-1306
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Nov 1;127(5):1297-1306
REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice.
Miller WP, Toro AL, Barber AJ, Dennis MD
Investigative ophthalmology & visual science 2019 May 1;60(6):2369-2379
Investigative ophthalmology & visual science 2019 May 1;60(6):2369-2379
Selenium supplementation suppresses immunological and serological features of lupus in B6.Sle1b mice.
Soni C, Sinha I, Fasnacht MJ, Olsen NJ, Rahman ZSM, Sinha R
Autoimmunity 2019 Mar;52(2):57-68
Autoimmunity 2019 Mar;52(2):57-68
PI3K inhibitors protect against glucocorticoid-induced skin atrophy.
Agarwal S, Mirzoeva S, Readhead B, Dudley JT, Budunova I
EBioMedicine 2019 Mar;41:526-537
EBioMedicine 2019 Mar;41:526-537
The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma.
Foltyn M, Luger AL, Lorenz NI, Sauer B, Mittelbronn M, Harter PN, Steinbach JP, Ronellenfitsch MW
British journal of cancer 2019 Mar;120(5):481-487
British journal of cancer 2019 Mar;120(5):481-487
Hypoxia-induced regulation of mTOR signaling by miR-7 targeting REDD1.
Seong M, Lee J, Kang H
Journal of cellular biochemistry 2019 Mar;120(3):4523-4532
Journal of cellular biochemistry 2019 Mar;120(3):4523-4532
Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury.
Liu Z, Li T, Zhu F, Deng S, Li X, He Y
Cell death & disease 2019 Mar 7;10(3):227
Cell death & disease 2019 Mar 7;10(3):227
Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli.
Gordon BS, Rossetti ML, Eroshkin AM
Physiological genomics 2019 Jun 1;51(6):208-217
Physiological genomics 2019 Jun 1;51(6):208-217
Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye.
Wang B, Peng L, Ouyang H, Wang L, He D, Zhong J, Xiao Y, Deng Y, Li M, Li S, Yuan J
Investigative ophthalmology & visual science 2019 Jul 1;60(8):2836-2847
Investigative ophthalmology & visual science 2019 Jul 1;60(8):2836-2847
Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1.
Dungan CM, Gordon BS, Williamson DL
Physiological reports 2019 Feb;7(4):e14011
Physiological reports 2019 Feb;7(4):e14011
Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway.
Nogami A, Okada K, Ishida S, Akiyama H, Umezawa Y, Miura O
Translational oncology 2019 Feb;12(2):336-349
Translational oncology 2019 Feb;12(2):336-349
Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.
Stevens AM, Xiang M, Heppler LN, Tošić I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA
Blood advances 2019 Dec 23;3(24):4215-4227
Blood advances 2019 Dec 23;3(24):4215-4227
Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy.
Lesovaya E, Agarwal S, Readhead B, Vinokour E, Baida G, Bhalla P, Kirsanov K, Yakubovskaya M, Platanias LC, Dudley JT, Budunova I
The Journal of investigative dermatology 2018 Sep;138(9):1935-1944
The Journal of investigative dermatology 2018 Sep;138(9):1935-1944
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Tiwarekar V, Wohlfahrt J, Fehrholz M, Scholz CJ, Kneitz S, Schneider-Schaulies J
Journal of virology 2018 Sep 1;92(17)
Journal of virology 2018 Sep 1;92(17)
Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.
Shimkus KL, Jefferson LS, Gordon BS, Kimball SR
Physiological reports 2018 Oct;6(20):e13891
Physiological reports 2018 Oct;6(20):e13891
Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle.
Gnimassou O, Fernández-Verdejo R, Brook M, Naslain D, Balan E, Sayda M, Cegielski J, Nielens H, Decottignies A, Demoulin JB, Smith K, Atherton PJ, Francaux M, Deldicque L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5272-5284
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5272-5284
Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy.
Baida G, Bhalla P, Yemelyanov A, Stechschulte LA, Shou W, Readhead B, Dudley JT, Sánchez ER, Budunova I
Oncotarget 2018 Oct 5;9(78):34772-34783
Oncotarget 2018 Oct 5;9(78):34772-34783
Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress.
Liu X, Cai S, Zhang C, Liu Z, Luo J, Xing B, Du X
Nucleic acids research 2018 Oct 12;46(18):9601-9616
Nucleic acids research 2018 Oct 12;46(18):9601-9616
Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma.
Chang B, Meng J, Zhu H, Du X, Sun L, Wang L, Li S, Yang G
Diagnostic pathology 2018 Nov 14;13(1):87
Diagnostic pathology 2018 Nov 14;13(1):87
Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation.
Ceelen JJM, Schols AMWJ, Thielen NGM, Haegens A, Gray DA, Kelders MCJM, de Theije CC, Langen RCJ
Respiratory research 2018 May 2;19(1):80
Respiratory research 2018 May 2;19(1):80
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR.
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV
Cell 2018 Jun 28;174(1):72-87.e32
Cell 2018 Jun 28;174(1):72-87.e32
Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia.
Yang J, Zhang Y, Tong J, Lv H, Zhang C, Chen ZJ
Biology of reproduction 2018 Jun 1;98(6):821-833
Biology of reproduction 2018 Jun 1;98(6):821-833
Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation.
Suryawan A, Davis TA
The Journal of nutrition 2018 Jun 1;148(6):825-833
The Journal of nutrition 2018 Jun 1;148(6):825-833
Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes.
Miller WP, Yang C, Mihailescu ML, Moore JA, Dai W, Barber AJ, Dennis MD
Diabetes 2018 Jan;67(1):110-119
Diabetes 2018 Jan;67(1):110-119
MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells.
Xu Q, Lin G, Xu H, Hu L, Wang Y, Du S, Deng W, Hu W, Cheng W, Jiang K
Oncology letters 2018 Jan;15(1):515-521
Oncology letters 2018 Jan;15(1):515-521
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.
Hodeib M, Ogrodzinski MP, Vergnes L, Reue K, Karlan BY, Lunt SY, Aspuria PP
Oncotarget 2018 Jan 9;9(3):4044-4060
Oncotarget 2018 Jan 9;9(3):4044-4060
Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N
Nature communications 2018 Jan 31;9(1):446
Nature communications 2018 Jan 31;9(1):446
REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activation.
Lee DK, Kim JH, Kim J, Choi S, Park M, Park W, Kim S, Lee KS, Kim T, Jung J, Choi YK, Ha KS, Won MH, Billiar TR, Kwon YG, Kim YM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Aug;32(8):4585-4599
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Aug;32(8):4585-4599
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Castro W, Chelbi ST, Niogret C, Ramon-Barros C, Welten SPM, Osterheld K, Wang H, Rota G, Morgado L, Vivier E, Raeber ME, Boyman O, Delorenzi M, Barras D, Ho PC, Oxenius A, Guarda G
Nature immunology 2018 Aug;19(8):809-820
Nature immunology 2018 Aug;19(8):809-820
Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes.
Cho SS, Kim KM, Yang JH, Kim JY, Park SJ, Kim SJ, Kim JK, Cho IJ, Ki SH
Free radical biology & medicine 2018 Aug 20;124:221-231
Free radical biology & medicine 2018 Aug 20;124:221-231
Gestational Protein Restriction in Wistar Rats; Effect of Taurine Supplementation on Properties of Newborn Skeletal Muscle.
Larsen LH, Sandø-Pedersen S, Ørstrup LKH, Grunnet N, Quistorff B, Mortensen OH
Advances in experimental medicine and biology 2017;975 Pt 1:413-433
Advances in experimental medicine and biology 2017;975 Pt 1:413-433
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.
Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, McMackin MZ, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez-Dominguez JA
Cell metabolism 2017 Sep 5;26(3):539-546.e5
Cell metabolism 2017 Sep 5;26(3):539-546.e5
Relationship between exercise volume and muscle protein synthesis in a rat model of resistance exercise.
Ogasawara R, Arihara Y, Takegaki J, Nakazato K, Ishii N
Journal of applied physiology (Bethesda, Md. : 1985) 2017 Oct 1;123(4):710-716
Journal of applied physiology (Bethesda, Md. : 1985) 2017 Oct 1;123(4):710-716
Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression.
Jeon MY, Min KJ, Woo SM, Seo SU, Kim S, Park JW, Kwon TK
International journal of molecular sciences 2017 Nov 29;18(12)
International journal of molecular sciences 2017 Nov 29;18(12)
Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.
Shimazu K, Tada Y, Morinaga T, Shingyoji M, Sekine I, Shimada H, Hiroshima K, Namiki T, Tatsumi K, Tagawa M
BMC cancer 2017 May 2;17(1):309
BMC cancer 2017 May 2;17(1):309
PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.
Salsman J, Stathakis A, Parker E, Chung D, Anthes LE, Koskowich KL, Lahsaee S, Gaston D, Kukurba KR, Smith KS, Chute IC, Léger D, Frost LD, Montgomery SB, Lewis SM, Eskiw C, Dellaire G
Scientific reports 2017 Mar 23;7:45038
Scientific reports 2017 Mar 23;7:45038
Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis.
Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK
Arthritis & rheumatology (Hoboken, N.J.) 2017 Jul;69(7):1418-1428
Arthritis & rheumatology (Hoboken, N.J.) 2017 Jul;69(7):1418-1428
RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4-Dependent Oxidative Stress Induced by Cigarette Smoke.
Hernández-Saavedra D, Sanders L, Perez MJ, Kosmider B, Smith LP, Mitchell JD, Yoshida T, Tuder RM
American journal of respiratory cell and molecular biology 2017 Jan;56(1):62-73
American journal of respiratory cell and molecular biology 2017 Jan;56(1):62-73
Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis.
Dungan CM, Williamson DL
Biochemical and biophysical research communications 2017 Jan 22;482(4):1067-1072
Biochemical and biophysical research communications 2017 Jan 22;482(4):1067-1072
Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells.
Wagner R, Stübiger G, Veigel D, Wuczkowski M, Lanzerstorfer P, Weghuber J, Karteris E, Nowikovsky K, Wilfinger-Lutz N, Singer CF, Colomer R, Benhamú B, López-Rodríguez ML, Valent P, Grunt TW
Oncotarget 2017 Feb 14;8(7):11600-11613
Oncotarget 2017 Feb 14;8(7):11600-11613
A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, González-Billalabeitia E, Hung MC, Song SJ, Song MS
Cancer cell 2017 Feb 13;31(2):208-224
Cancer cell 2017 Feb 13;31(2):208-224
Neuromuscular Electrical Stimulation Combined with Protein Ingestion Preserves Thigh Muscle Mass But Not Muscle Function in Healthy Older Adults During 5 Days of Bed Rest.
Reidy PT, McKenzie AI, Brunker P, Nelson DS, Barrows KM, Supiano M, LaStayo PC, Drummond MJ
Rejuvenation research 2017 Dec;20(6):449-461
Rejuvenation research 2017 Dec;20(6):449-461
REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.
Gordon BS, Steiner JL, Rossetti ML, Qiao S, Ellisen LW, Govindarajan SS, Eroshkin AM, Williamson DL, Coen PM
American journal of physiology. Endocrinology and metabolism 2017 Dec 1;313(6):E737-E747
American journal of physiology. Endocrinology and metabolism 2017 Dec 1;313(6):E737-E747
Implication of REDD1 in the activation of inflammatory pathways.
Pastor F, Dumas K, Barthélémy MA, Regazzetti C, Druelle N, Peraldi P, Cormont M, Tanti JF, Giorgetti-Peraldi S
Scientific reports 2017 Aug 1;7(1):7023
Scientific reports 2017 Aug 1;7(1):7023
Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis.
Crowell KT, Soybel DI, Lang CH
Shock (Augusta, Ga.) 2017 Apr;47(4):463-473
Shock (Augusta, Ga.) 2017 Apr;47(4):463-473
Time-Course Change of Redd1 Expressions in the Hippocampal CA1 Region Following Chronic Cerebral Hypoperfusion.
Park JA, Lee CH
Cellular and molecular neurobiology 2017 Apr;37(3):563-569
Cellular and molecular neurobiology 2017 Apr;37(3):563-569
Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts.
Grainger DL, Kutzler L, Rannels SL, Kimball SR
F1000Research 2016;5:250
F1000Research 2016;5:250
Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle.
D'Hulst G, Ferri A, Naslain D, Bertrand L, Horman S, Francaux M, Bishop DJ, Deldicque L
Hypoxia (Auckland, N.Z.) 2016;4:1-14
Hypoxia (Auckland, N.Z.) 2016;4:1-14
Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of rapamycin in human placental BeWo cells under hypoxia.
Zhou F, Guan LB, Yu P, Wang XD, Hu YY
Placenta 2016 Sep;45:24-31
Placenta 2016 Sep;45:24-31
Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue.
Crowell KT, Steiner JL, Coleman CS, Lang CH
Alcoholism, clinical and experimental research 2016 Sep;40(9):1832-45
Alcoholism, clinical and experimental research 2016 Sep;40(9):1832-45
Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy.
Alvarez-Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch KM, Shen T, Su AI, Lotz MK
Osteoarthritis and cartilage 2016 Sep;24(9):1639-47
Osteoarthritis and cartilage 2016 Sep;24(9):1639-47
Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease.
Canal M, Martín-Flores N, Pérez-Sisqués L, Romaní-Aumedes J, Altas B, Man HY, Kawabe H, Alberch J, Malagelada C
Oncotarget 2016 Sep 13;7(37):58813-58831
Oncotarget 2016 Sep 13;7(37):58813-58831
Loss of REDD1 augments the rate of the overload-induced increase in muscle mass.
Gordon BS, Liu C, Steiner JL, Nader GA, Jefferson LS, Kimball SR
American journal of physiology. Regulatory, integrative and comparative physiology 2016 Sep 1;311(3):R545-57
American journal of physiology. Regulatory, integrative and comparative physiology 2016 Sep 1;311(3):R545-57
Hypoxia-induced regulation of placental REDD1 and mTOR was impaired in a rat model of estrogen-induced cholestasis.
Zhou F, Chen H, Wang X, Yu P, Hu Y
Archives of gynecology and obstetrics 2016 Nov;294(6):1219-1226
Archives of gynecology and obstetrics 2016 Nov;294(6):1219-1226
DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling.
Gharibi B, Ghuman M, Hughes FJ
Scientific reports 2016 Nov 23;6:36889
Scientific reports 2016 Nov 23;6:36889
Acute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice Is REDD-1 and mTOR-Independent.
Steiner JL, Kimball SR, Lang CH
Alcohol and alcoholism (Oxford, Oxfordshire) 2016 May;51(3):242-50
Alcohol and alcoholism (Oxford, Oxfordshire) 2016 May;51(3):242-50
Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1.
Watson A, Lipina C, McArdle HJ, Taylor PM, Hundal HS
Cellular signalling 2016 May;28(5):412-424
Cellular signalling 2016 May;28(5):412-424
Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells.
Moore JA, Miller WP, Dennis MD
Cellular signalling 2016 May;28(5):384-390
Cellular signalling 2016 May;28(5):384-390
C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion.
Barakat DJ, Mendonca J, Barberi T, Zhang J, Kachhap SK, Paz-Priel I, Friedman AD
Cancer letters 2016 May 28;375(1):152-161
Cancer letters 2016 May 28;375(1):152-161
Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging.
Choi HS, Ahn JH, Park JH, Won MH, Lee CH
Molecular medicine reports 2016 Mar;13(3):2409-14
Molecular medicine reports 2016 Mar;13(3):2409-14
RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death.
Martín-Flores N, Romaní-Aumedes J, Rué L, Canal M, Sanders P, Straccia M, Allen ND, Alberch J, Canals JM, Pérez-Navarro E, Malagelada C
Molecular neurobiology 2016 Jul;53(5):2857-2868
Molecular neurobiology 2016 Jul;53(5):2857-2868
Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells.
Woo SM, Lee WK, Min KJ, Kim DE, Park SH, Nam SI, Kwon TK
Molecular medicine reports 2016 Jul;14(1):845-50
Molecular medicine reports 2016 Jul;14(1):845-50
Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis and intracellular signalling in young males.
McKendry J, Pérez-López A, McLeod M, Luo D, Dent JR, Smeuninx B, Yu J, Taylor AE, Philp A, Breen L
Experimental physiology 2016 Jul 1;101(7):866-82
Experimental physiology 2016 Jul 1;101(7):866-82
Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle.
Dungan CM, Li Z, Wright DC, Williamson DL
Muscle & nerve 2016 Jan;53(1):107-17
Muscle & nerve 2016 Jan;53(1):107-17
Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity.
Francaux M, Demeulder B, Naslain D, Fortin R, Lutz O, Caty G, Deldicque L
Nutrients 2016 Jan 15;8(1)
Nutrients 2016 Jan 15;8(1)
Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum.
Black AJ, Gordon BS, Dennis MD, Jefferson LS, Kimball SR
Biochemistry and biophysics reports 2016 Dec;8:296-301
Biochemistry and biophysics reports 2016 Dec;8:296-301
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling.
Dungan CM, Li J, Williamson DL
Lipids 2016 Aug;51(8):905-12
Lipids 2016 Aug;51(8):905-12
Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury.
Park KM, Teoh JP, Wang Y, Broskova Z, Bayoumi AS, Tang Y, Su H, Weintraub NL, Kim IM
American journal of physiology. Heart and circulatory physiology 2016 Aug 1;311(2):H371-83
American journal of physiology. Heart and circulatory physiology 2016 Aug 1;311(2):H371-83
REDD1 Is Essential for Optimal T Cell Proliferation and Survival.
Reuschel EL, Wang J, Shivers DK, Muthumani K, Weiner DB, Ma Z, Finkel TH
PloS one 2015;10(8):e0136323
PloS one 2015;10(8):e0136323
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Sesen J, Dahan P, Scotland SJ, Saland E, Dang VT, Lemarié A, Tyler BM, Brem H, Toulas C, Cohen-Jonathan Moyal E, Sarry JE, Skuli N
PloS one 2015;10(4):e0123721
PloS one 2015;10(4):e0123721
A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation.
Papageorgiou A, Rapley J, Mesirov JP, Tamayo P, Avruch J
PloS one 2015;10(3):e0116096
PloS one 2015;10(3):e0116096
Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.
Philp A, Schenk S, Perez-Schindler J, Hamilton DL, Breen L, Laverone E, Jeromson S, Phillips SM, Baar K
The Journal of physiology 2015 Sep 15;593(18):4275-84
The Journal of physiology 2015 Sep 15;593(18):4275-84
Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages.
Lee DK, Kim JH, Kim WS, Jeoung D, Lee H, Ha KS, Won MH, Kwon YG, Kim YM
FEBS letters 2015 Sep 14;589(19 Pt B):2859-65
FEBS letters 2015 Sep 14;589(19 Pt B):2859-65
Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801.
Wu X, Su J, Chen L, Ma B, Gu X, Zhu L
Cellular and molecular neurobiology 2015 Oct;35(7):943-52
Cellular and molecular neurobiology 2015 Oct;35(7):943-52
Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Ponzoni M, Bossi G, Federico V, La Rosa F, Ricciardi MR, Lesma E, De Meo PD, Castrignanò T, Petrucci MT, Pisani F, Chesi M, Bergsagel PL, Floridi A, Tonon G, Passananti C, Blandino G, Fanciulli M
The EMBO journal 2015 May 5;34(9):1214-30
The EMBO journal 2015 May 5;34(9):1214-30
Moderate alcohol consumption does not impair overload-induced muscle hypertrophy and protein synthesis.
Steiner JL, Gordon BS, Lang CH
Physiological reports 2015 Mar;3(3)
Physiological reports 2015 Mar;3(3)
Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes.
Regazzetti C, Dumas K, Lacas-Gervais S, Pastor F, Peraldi P, Bonnafous S, Dugail I, Le Lay S, Valet P, Le Marchand-Brustel Y, Tran A, Gual P, Tanti JF, Cormont M, Giorgetti-Peraldi S
Endocrinology 2015 Mar;156(3):789-801
Endocrinology 2015 Mar;156(3):789-801
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Yang CS, Matsuura K, Huang NJ, Robeson AC, Huang B, Zhang L, Kornbluth S
Oncogene 2015 Jun;34(25):3264-72
Oncogene 2015 Jun;34(25):3264-72
The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.
Benyoucef A, Calvo J, Renou L, Arcangeli ML, van den Heuvel A, Amsellem S, Mehrpour M, Larghero J, Soler E, Naguibneva I, Pflumio F
Stem cells (Dayton, Ohio) 2015 Jul;33(7):2268-79
Stem cells (Dayton, Ohio) 2015 Jul;33(7):2268-79
REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.
Baida G, Bhalla P, Kirsanov K, Lesovaya E, Yakubovskaya M, Yuen K, Guo S, Lavker RM, Readhead B, Dudley JT, Budunova I
EMBO molecular medicine 2015 Jan;7(1):42-58
EMBO molecular medicine 2015 Jan;7(1):42-58
Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction.
Steiner JL, Lang CH
Alcoholism, clinical and experimental research 2015 Jan;39(1):1-10
Alcoholism, clinical and experimental research 2015 Jan;39(1):1-10
Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer.
Shao C, Ahmad N, Hodges K, Kuang S, Ratliff T, Liu X
The Journal of biological chemistry 2015 Jan 23;290(4):2024-33
The Journal of biological chemistry 2015 Jan 23;290(4):2024-33
Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents.
Dennis MD, Kimball SR, Fort PE, Jefferson LS
The Journal of biological chemistry 2015 Feb 6;290(6):3865-74
The Journal of biological chemistry 2015 Feb 6;290(6):3865-74
Sepsis attenuates the anabolic response to skeletal muscle contraction.
Steiner JL, Lang CH
Shock (Augusta, Ga.) 2015 Apr;43(4):344-51
Shock (Augusta, Ga.) 2015 Apr;43(4):344-51
REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury.
Morquette B, Morquette P, Agostinone J, Feinstein E, McKinney RA, Kolta A, Di Polo A
Cell death and differentiation 2015 Apr;22(4):612-25
Cell death and differentiation 2015 Apr;22(4):612-25
Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.
Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR
The Journal of nutrition 2015 Apr;145(4):708-13
The Journal of nutrition 2015 Apr;145(4):708-13
ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.
Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, Wang Y
Molecular cancer therapeutics 2015 Apr;14(4):877-88
Molecular cancer therapeutics 2015 Apr;14(4):877-88
Effects of Salidroside on cobalt chloride-induced hypoxia damage and mTOR signaling repression in PC12 cells.
Zhong X, Lin R, Li Z, Mao J, Chen L
Biological & pharmaceutical bulletin 2014;37(7):1199-206
Biological & pharmaceutical bulletin 2014;37(7):1199-206
Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy.
Wei W, Hu YY
Placenta 2014 Sep;35(9):732-6
Placenta 2014 Sep;35(9):732-6
Changes and expressions of Redd1 in neurons and glial cells in the gerbil hippocampus proper following transient global cerebral ischemia.
Lee CH, Park JH, Cho JH, Ahn JH, Yan BC, Lee JC, Shin MC, Cheon SH, Cho YS, Cho JH, Kwon YG, Lee DK, Kim YM, Won MH
Journal of the neurological sciences 2014 Sep 15;344(1-2):43-50
Journal of the neurological sciences 2014 Sep 15;344(1-2):43-50
Nuclear factor of activated T-cells 5 increases intestinal goblet cell differentiation through an mTOR/Notch signaling pathway.
Zhou Y, Wang Q, Weiss HL, Evers BM
Molecular biology of the cell 2014 Sep 15;25(18):2882-90
Molecular biology of the cell 2014 Sep 15;25(18):2882-90
Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling.
Dungan CM, Wright DC, Williamson DL
Biochemical and biophysical research communications 2014 Oct 31;453(4):778-83
Biochemical and biophysical research communications 2014 Oct 31;453(4):778-83
Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.
Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ
The Journal of biological chemistry 2014 Oct 17;289(42):28942-55
The Journal of biological chemistry 2014 Oct 17;289(42):28942-55
Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.
Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR
American journal of physiology. Endocrinology and metabolism 2014 Oct 15;307(8):E703-11
American journal of physiology. Endocrinology and metabolism 2014 Oct 15;307(8):E703-11
REDD1 attenuates cardiac hypertrophy via enhancing autophagy.
Liu C, Xue R, Wu D, Wu L, Chen C, Tan W, Chen Y, Dong Y
Biochemical and biophysical research communications 2014 Nov 7;454(1):215-20
Biochemical and biophysical research communications 2014 Nov 7;454(1):215-20
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS
Nature medicine 2014 May;20(5):531-5
Nature medicine 2014 May;20(5):531-5
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells.
Gu Y, Kaufman JL, Bernal L, Torre C, Matulis SM, Harvey RD, Chen J, Sun SY, Boise LH, Lonial S
Blood 2014 May 22;123(21):3269-76
Blood 2014 May 22;123(21):3269-76
Ambient hypoxia enhances the loss of muscle mass after extensive injury.
Chaillou T, Koulmann N, Meunier A, Pugnière P, McCarthy JJ, Beaudry M, Bigard X
Pflugers Archiv : European journal of physiology 2014 Mar;466(3):587-98
Pflugers Archiv : European journal of physiology 2014 Mar;466(3):587-98
Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines.
Yanagawa Y, Hiraide S, Matsumoto M, Togashi H
Immunology letters 2014 Mar-Apr;158(1-2):109-15
Immunology letters 2014 Mar-Apr;158(1-2):109-15
REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.
Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR
Science signaling 2014 Jul 22;7(335):ra68
Science signaling 2014 Jul 22;7(335):ra68
Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice.
Sriram S, Subramanian S, Juvvuna PK, McFarlane C, Salerno MS, Kambadur R, Sharma M
The Journal of biological chemistry 2014 Feb 28;289(9):5784-98
The Journal of biological chemistry 2014 Feb 28;289(9):5784-98
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H
The Journal of biological chemistry 2014 Feb 14;289(7):4083-94
The Journal of biological chemistry 2014 Feb 14;289(7):4083-94
REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.
Britto FA, Begue G, Rossano B, Docquier A, Vernus B, Sar C, Ferry A, Bonnieu A, Ollendorff V, Favier FB
American journal of physiology. Endocrinology and metabolism 2014 Dec 1;307(11):E983-93
American journal of physiology. Endocrinology and metabolism 2014 Dec 1;307(11):E983-93
Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle.
Hayasaka M, Tsunekawa H, Yoshinaga M, Murakami T
Physiological reports 2014 Dec 1;2(12)
Physiological reports 2014 Dec 1;2(12)
Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.
Romaní-Aumedes J, Canal M, Martín-Flores N, Sun X, Pérez-Fernández V, Wewering S, Fernández-Santiago R, Ezquerra M, Pont-Sunyer C, Lafuente A, Alberch J, Luebbert H, Tolosa E, Levy OA, Greene LA, Malagelada C
Cell death & disease 2014 Aug 7;5:e1364
Cell death & disease 2014 Aug 7;5:e1364
Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.
Williamson DL, Li Z, Tuder RM, Feinstein E, Kimball SR, Dungan CM
Journal of applied physiology (Bethesda, Md. : 1985) 2014 Aug 1;117(3):246-56
Journal of applied physiology (Bethesda, Md. : 1985) 2014 Aug 1;117(3):246-56
Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia.
Sinha I, Allen JE, Pinto JT, Sinha R
Cancer medicine 2014 Apr;3(2):252-64
Cancer medicine 2014 Apr;3(2):252-64
Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling.
Malaguarnera R, Sacco A, Morcavallo A, Squatrito S, Migliaccio A, Morrione A, Maggiolini M, Belfiore A
Endocrinology 2014 Apr;155(4):1207-21
Endocrinology 2014 Apr;155(4):1207-21
Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner.
Park EJ, Min KJ, Choi KS, Kwon TK
Experimental cell research 2014 Apr 15;323(1):144-154
Experimental cell research 2014 Apr 15;323(1):144-154
mTORC1 dependent regulation of REDD1 protein stability.
Tan CY, Hagen T
PloS one 2013;8(5):e63970
PloS one 2013;8(5):e63970
Zoledronic acid-induced cytotoxicity through endoplasmic reticulum stress triggered REDD1-mTOR pathway in breast cancer cells.
Lan YC, Chang CL, Sung MT, Yin PH, Hsu CC, Wang KC, Lee HC, Tseng LM, Chi CW
Anticancer research 2013 Sep;33(9):3807-14
Anticancer research 2013 Sep;33(9):3807-14
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids.
Durán RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E
Oncogene 2013 Sep 19;32(38):4549-56
Oncogene 2013 Sep 19;32(38):4549-56
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues.
Schupp M, Chen F, Briggs ER, Rao S, Pelzmann HJ, Pessentheiner AR, Bogner-Strauss JG, Lazar MA, Baldwin D, Prokesch A
BMC genomics 2013 Nov 5;14:758
BMC genomics 2013 Nov 5;14:758
Post-translational regulation of mTOR complex 1 in hypoxia and reoxygenation.
Tan CY, Hagen T
Cellular signalling 2013 May;25(5):1235-44
Cellular signalling 2013 May;25(5):1235-44
Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway.
Han J, Xiao Z, Chen L, Chen B, Li X, Han S, Zhao Y, Dai J
Biomaterials 2013 Mar;34(8):1921-8
Biomaterials 2013 Mar;34(8):1921-8
Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma.
Jang JH, Iqbal T, Min KJ, Kim S, Park JW, Son EI, Lee TJ, Kwon TK
Toxicology in vitro : an international journal published in association with BIBRA 2013 Mar;27(2):588-96
Toxicology in vitro : an international journal published in association with BIBRA 2013 Mar;27(2):588-96
FIP200 regulates targeting of Atg16L1 to the isolation membrane.
Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N
EMBO reports 2013 Mar 1;14(3):284-91
EMBO reports 2013 Mar 1;14(3):284-91
Salidroside protects against hydrogen peroxide-induced injury in HUVECs via the regulation of REDD1 and mTOR activation.
Xu MC, Shi HM, Wang H, Gao XF
Molecular medicine reports 2013 Jul;8(1):147-53
Molecular medicine reports 2013 Jul;8(1):147-53
Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer.
Jin Y, Qu S, Tesikova M, Wang L, Kristian A, Mælandsmo GM, Kong H, Zhang T, Jerónimo C, Teixeira MR, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood AK, Lopez-Berestein G, Danielsen HE, Ozpolat B, Saatcioglu F
Proceedings of the National Academy of Sciences of the United States of America 2013 Jul 9;110(28):E2572-81
Proceedings of the National Academy of Sciences of the United States of America 2013 Jul 9;110(28):E2572-81
RTP801 is required for ceramide-induced cell-specific death in the murine lung.
Kamocki K, Van Demark M, Fisher A, Rush NI, Presson RG Jr, Hubbard W, Berdyshev EV, Adamsky S, Feinstein E, Gandjeva A, Tuder RM, Petrache I
American journal of respiratory cell and molecular biology 2013 Jan;48(1):87-93
American journal of respiratory cell and molecular biology 2013 Jan;48(1):87-93
Proteasome-dependent activation of mammalian target of rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling following denervation.
Quy PN, Kuma A, Pierre P, Mizushima N
The Journal of biological chemistry 2013 Jan 11;288(2):1125-34
The Journal of biological chemistry 2013 Jan 11;288(2):1125-34
Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins.
Hulmi JJ, Oliveira BM, Silvennoinen M, Hoogaars WM, Ma H, Pierre P, Pasternack A, Kainulainen H, Ritvos O
American journal of physiology. Endocrinology and metabolism 2013 Jan 1;304(1):E41-50
American journal of physiology. Endocrinology and metabolism 2013 Jan 1;304(1):E41-50
Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.
Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM
Autophagy 2013 Feb 1;9(2):208-19
Autophagy 2013 Feb 1;9(2):208-19
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).
Dennis MD, McGhee NK, Jefferson LS, Kimball SR
Cellular signalling 2013 Dec;25(12):2709-16
Cellular signalling 2013 Dec;25(12):2709-16
Sustained overexpression of Redd1 leads to Akt activation involved in cell survival.
Jin HO, Hong SE, Kim JH, Choi HN, Kim K, An S, Choe TB, Hwang CS, Lee JH, Kim JI, Kim HA, Kim EK, Noh WC, Hong YJ, Hong SI, Lee JK, Park IC
Cancer letters 2013 Aug 19;336(2):319-24
Cancer letters 2013 Aug 19;336(2):319-24
REDD1 protects osteoblast cells from gamma radiation-induced premature senescence.
Li XH, Ha CT, Fu D, Xiao M
PloS one 2012;7(5):e36604
PloS one 2012;7(5):e36604
Regulated in development and DNA damage responses -1 (REDD1) protein contributes to insulin signaling pathway in adipocytes.
Regazzetti C, Dumas K, Le Marchand-Brustel Y, Peraldi P, Tanti JF, Giorgetti-Peraldi S
PloS one 2012;7(12):e52154
PloS one 2012;7(12):e52154
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
Li XH, Ha CT, Fu D, Xiao M
PloS one 2012;7(11):e48700
PloS one 2012;7(11):e48700
REDD1 expression in placenta during human gestation.
Hu YY, Liu JC, Xing AY, You Y, Wang XD
Reproductive sciences (Thousand Oaks, Calif.) 2012 Sep;19(9):995-1000
Reproductive sciences (Thousand Oaks, Calif.) 2012 Sep;19(9):995-1000
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.
Zhao Y, Xiong X, Jia L, Sun Y
Cell death & disease 2012 Sep 6;3:e386
Cell death & disease 2012 Sep 6;3:e386
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S
Biochemical pharmacology 2012 Sep 1;84(5):598-611
Biochemical pharmacology 2012 Sep 1;84(5):598-611
Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFs.
Ait Ghezala H, Jolles B, Salhi S, Castrillo K, Carpentier W, Cagnard N, Bruhat A, Fafournoux P, Jean-Jean O
Nucleic acids research 2012 Oct;40(19):9557-70
Nucleic acids research 2012 Oct;40(19):9557-70
Hypoxia transiently affects skeletal muscle hypertrophy in a functional overload model.
Chaillou T, Koulmann N, Simler N, Meunier A, Serrurier B, Chapot R, Peinnequin A, Beaudry M, Bigard X
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Mar 1;302(5):R643-54
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Mar 1;302(5):R643-54
Retina expression and cross-species validation of gene silencing by PF-655, a small interfering RNA against RTP801 for the treatment of ocular disease.
Lee DU, Huang W, Rittenhouse KD, Jessen B
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2012 Jun;28(3):222-30
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2012 Jun;28(3):222-30
eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells.
Hernández-Jiménez M, Ayuso MI, Pérez-Morgado MI, García-Recio EM, Alcázar A, Martín ME, González VM
Biochimica et biophysica acta 2012 Feb;1823(2):430-8
Biochimica et biophysica acta 2012 Feb;1823(2):430-8
Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy.
Hulmi JJ, Silvennoinen M, Lehti M, Kivelä R, Kainulainen H
American journal of physiology. Endocrinology and metabolism 2012 Feb 1;302(3):E307-15
American journal of physiology. Endocrinology and metabolism 2012 Feb 1;302(3):E307-15
Nuclear factor of activated T-cell c3 inhibition of mammalian target of rapamycin signaling through induction of regulated in development and DNA damage response 1 in human intestinal cells.
Zhou Y, Wang Q, Guo Z, Weiss HL, Evers BM
Molecular biology of the cell 2012 Aug;23(15):2963-72
Molecular biology of the cell 2012 Aug;23(15):2963-72
Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.
Kucejova B, Peña-Llopis S, Yamasaki T, Sivanand S, Tran TA, Alexander S, Wolff NC, Lotan Y, Xie XJ, Kabbani W, Kapur P, Brugarolas J
Molecular cancer research : MCR 2011 Sep;9(9):1255-65
Molecular cancer research : MCR 2011 Sep;9(9):1255-65
TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.
Jin HO, Seo SK, Kim YS, Woo SH, Lee KH, Yi JY, Lee SJ, Choe TB, Lee JH, An S, Hong SI, Park IC
Oncogene 2011 Sep 1;30(35):3792-801
Oncogene 2011 Sep 1;30(35):3792-801
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling.
Lisse TS, Liu T, Irmler M, Beckers J, Chen H, Adams JS, Hewison M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Mar;25(3):937-47
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Mar;25(3):937-47
RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration.
Malagelada C, López-Toledano MA, Willett RT, Jin ZH, Shelanski ML, Greene LA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 2;31(9):3186-96
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Mar 2;31(9):3186-96
AMPK regulates metabolism and survival in response to ionizing radiation.
Zannella VE, Cojocari D, Hilgendorf S, Vellanki RN, Chung S, Wouters BG, Koritzinsky M
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Jun;99(3):293-9
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Jun;99(3):293-9
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P, Tanti JF, Giorgetti-Peraldi S, Bost F
Cancer research 2011 Jul 1;71(13):4366-72
Cancer research 2011 Jul 1;71(13):4366-72
Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle.
Murakami T, Hasegawa K, Yoshinaga M
Biochemical and biophysical research communications 2011 Feb 25;405(4):615-9
Biochemical and biophysical research communications 2011 Feb 25;405(4):615-9
Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.
Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H
Cell metabolism 2011 Feb 2;13(2):170-82
Cell metabolism 2011 Feb 2;13(2):170-82
Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation.
Song S, Abdelmohsen K, Zhang Y, Becker KG, Gorospe M, Bernier M
The Journal of pharmacology and experimental therapeutics 2011 Dec;339(3):905-13
The Journal of pharmacology and experimental therapeutics 2011 Dec;339(3):905-13
A novel cardioprotective p38-MAPK/mTOR pathway.
Hernández G, Lal H, Fidalgo M, Guerrero A, Zalvide J, Force T, Pombo CM
Experimental cell research 2011 Dec 10;317(20):2938-49
Experimental cell research 2011 Dec 10;317(20):2938-49
Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
Molitoris JK, McColl KS, Swerdlow S, Matsuyama M, Lam M, Finkel TH, Matsuyama S, Distelhorst CW
The Journal of biological chemistry 2011 Aug 26;286(34):30181-9
The Journal of biological chemistry 2011 Aug 26;286(34):30181-9
Redd1 inhibits the invasiveness of non-small cell lung cancer cells.
Jin HO, Seo SK, Woo SH, Kim YS, Hong SE, Yi JY, Noh WC, Kim EK, Lee JK, Hong SI, Choe TB, Park IC
Biochemical and biophysical research communications 2011 Apr 15;407(3):507-11
Biochemical and biophysical research communications 2011 Apr 15;407(3):507-11
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men.
Fry CS, Glynn EL, Drummond MJ, Timmerman KL, Fujita S, Abe T, Dhanani S, Volpi E, Rasmussen BB
Journal of applied physiology (Bethesda, Md. : 1985) 2010 May;108(5):1199-209
Journal of applied physiology (Bethesda, Md. : 1985) 2010 May;108(5):1199-209
REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss.
Wu Y, Zhao W, Zhao J, Zhang Y, Qin W, Pan J, Bauman WA, Blitzer RD, Cardozo C
Endocrinology 2010 Mar;151(3):1050-9
Endocrinology 2010 Mar;151(3):1050-9
Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia.
Favier FB, Costes F, Defour A, Bonnefoy R, Lefai E, Baugé S, Peinnequin A, Benoit H, Freyssenet D
American journal of physiology. Regulatory, integrative and comparative physiology 2010 Jun;298(6):R1659-66
American journal of physiology. Regulatory, integrative and comparative physiology 2010 Jun;298(6):R1659-66
miR-221 overexpression contributes to liver tumorigenesis.
Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 5;107(1):264-9
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 5;107(1):264-9
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jan 20;30(3):1166-75
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jan 20;30(3):1166-75
Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.
Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S
The Journal of biological chemistry 2010 Feb 19;285(8):5157-64
The Journal of biological chemistry 2010 Feb 19;285(8):5157-64
Plzf regulates germline progenitor self-renewal by opposing mTORC1.
Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP
Cell 2010 Aug 6;142(3):468-79
Cell 2010 Aug 6;142(3):468-79
The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling.
Lin CJ, Robert F, Sukarieh R, Michnick S, Pelletier J
Cancer research 2010 Apr 15;70(8):3199-208
Cancer research 2010 Apr 15;70(8):3199-208
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress.
King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang YL, Cohen I, Shtivelman E
PloS one 2009 Sep 30;4(9):e7283
PloS one 2009 Sep 30;4(9):e7283
Glucocorticoid-mediated repression of REDD1 mRNA expression in rat fetal distal lung epithelial cells.
Otulakowski G, Duan W, Sarangapani A, Gandhi S, O'Brodovich H
Pediatric research 2009 May;65(5):514-9
Pediatric research 2009 May;65(5):514-9
The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.
Ohyashiki JH, Kobayashi C, Hamamura R, Okabe S, Tauchi T, Ohyashiki K
Cancer science 2009 May;100(5):970-7
Cancer science 2009 May;100(5):970-7
REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells.
Chang B, Liu G, Yang G, Mercado-Uribe I, Huang M, Liu J
Cell cycle (Georgetown, Tex.) 2009 Mar 1;8(5):780-6
Cell cycle (Georgetown, Tex.) 2009 Mar 1;8(5):780-6
Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling.
Glazer HP, Osipov RM, Clements RT, Sellke FW, Bianchi C
Cell cycle (Georgetown, Tex.) 2009 Jun 1;8(11):1738-46
Cell cycle (Georgetown, Tex.) 2009 Jun 1;8(11):1738-46
SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression.
Jin HO, Seo SK, Woo SH, Kim ES, Lee HC, Yoo DH, Choe TB, Hong SI, Kim JI, Park IC
FEBS letters 2009 Jan 5;583(1):123-7
FEBS letters 2009 Jan 5;583(1):123-7
Hypoxia induces resistance to 5-fluorouracil in oral cancer cells via G(1) phase cell cycle arrest.
Yoshiba S, Ito D, Nagumo T, Shirota T, Hatori M, Shintani S
Oral oncology 2009 Feb;45(2):109-15
Oral oncology 2009 Feb;45(2):109-15
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
Whitney ML, Jefferson LS, Kimball SR
Biochemical and biophysical research communications 2009 Feb 6;379(2):451-5
Biochemical and biophysical research communications 2009 Feb 6;379(2):451-5
Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes.
Frost RA, Huber D, Pruznak A, Lang CH
Journal of cellular biochemistry 2009 Dec 1;108(5):1192-202
Journal of cellular biochemistry 2009 Dec 1;108(5):1192-202
REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.
Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG
EMBO reports 2009 Aug;10(8):866-72
EMBO reports 2009 Aug;10(8):866-72
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis.
Drummond MJ, Miyazaki M, Dreyer HC, Pennings B, Dhanani S, Volpi E, Esser KA, Rasmussen BB
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Apr;106(4):1403-11
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Apr;106(4):1403-11
Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress.
Jin HO, Seo SK, Woo SH, Kim ES, Lee HC, Yoo DH, An S, Choe TB, Lee SJ, Hong SI, Rhee CH, Kim JI, Park IC
Free radical biology & medicine 2009 Apr 15;46(8):1158-67
Free radical biology & medicine 2009 Apr 15;46(8):1158-67
Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.
Schneider A, Younis RH, Gutkind JS
Neoplasia (New York, N.Y.) 2008 Nov;10(11):1295-302
Neoplasia (New York, N.Y.) 2008 Nov;10(11):1295-302
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft.
Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak PK, Toleno DM, Ramaswamy K, Siegmund KD, Hacia JG
BMC genomics 2008 Nov 3;9:521
BMC genomics 2008 Nov 3;9:521
Acute alcohol intoxication increases REDD1 in skeletal muscle.
Lang CH, Frost RA, Vary TC
Alcoholism, clinical and experimental research 2008 May;32(5):796-805
Alcoholism, clinical and experimental research 2008 May;32(5):796-805
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.
Kimball SR, Do AND, Kutzler L, Cavener DR, Jefferson LS
The Journal of biological chemistry 2008 Feb 8;283(6):3465-3475
The Journal of biological chemistry 2008 Feb 8;283(6):3465-3475
RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation.
Malagelada C, Jin ZH, Greene LA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 31;28(53):14363-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Dec 31;28(53):14363-71
Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
Otulakowski G, Duan W, Gandhi S, O'brodovich H
American journal of respiratory cell and molecular biology 2007 Oct;37(4):457-66
American journal of respiratory cell and molecular biology 2007 Oct;37(4):457-66
Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.
Jin HO, An S, Lee HC, Woo SH, Seo SK, Choe TB, Yoo DH, Lee SB, Um HD, Lee SJ, Park MJ, Kim JI, Hong SI, Rhee CH, Park IC
Cellular signalling 2007 Jul;19(7):1393-403
Cellular signalling 2007 Jul;19(7):1393-403
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.
Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR
The Journal of biological chemistry 2006 Dec 22;281(51):39128-34
The Journal of biological chemistry 2006 Dec 22;281(51):39128-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10638-1-AP(REDD1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-REDD1 (IP:10638-1-AP, 3ug; Detection:10638-1-AP 1:500) with MCF-7 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 10638-1-AP(REDD1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The REDD1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human REDD1. This antibody recognizes human, mouse, rat antigen. The REDD1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
