FAB590P-025
antibody from R&D Systems
Targeting: CCR6
BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22
Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Flow cytometry [2]
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Validation data
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- Product number
- FAB590P-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human/Mouse CCR6 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse CCR6-transfected rat RBL cells but not the parent cell line or cells transfected with mouse CCR5. Detects human CCR6 in flow cytometry.
- Reactivity
- Human, Mouse
- Host
- Rat
- Antigen sequence
O54689
- Isotype
- IgG
- Antibody clone number
- 140706
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells.
Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFκB and ERK.
The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages.
Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.
Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation.
Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
ATP drives lamina propria T(H)17 cell differentiation.
Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.
Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.
Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou HK, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T
Nature communications 2018 Oct 12;9(1):4231
Nature communications 2018 Oct 12;9(1):4231
Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFκB and ERK.
Badr G, Sayed A, Abdel-Maksoud MA, Mohamed AO, El-Amir A, Abdel-Ghaffar FA, Al-Quraishy S, Mahmoud MH
PloS one 2015;10(4):e0125340
PloS one 2015;10(4):e0125340
The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages.
Boyle ST, Faulkner JW, McColl SR, Kochetkova M
Molecular cancer 2015 Jun 6;14:115
Molecular cancer 2015 Jun 6;14:115
Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
Klein M, Brouwer MC, Angele B, Geldhoff M, Marquez G, Varona R, Häcker G, Schmetzer H, Häcker H, Hammerschmidt S, van der Ende A, Pfister HW, van de Beek D, Koedel U
PloS one 2014;9(4):e93057
PloS one 2014;9(4):e93057
Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.
Angkasekwinai P, Sringkarin N, Supasorn O, Fungkrajai M, Wang YH, Chayakulkeeree M, Ngamskulrungroj P, Angkasekwinai N, Pattanapanyasat K
Infection and immunity 2014 Sep;82(9):3880-90
Infection and immunity 2014 Sep;82(9):3880-90
Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation.
Cai Y, Xue F, Fleming C, Yang J, Ding C, Ma Y, Liu M, Zhang HG, Zheng J, Xiong N, Yan J
Nature communications 2014 Jun 9;5:3986
Nature communications 2014 Jun 9;5:3986
Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
Peng H, Jiang X, Chen Y, Sojka DK, Wei H, Gao X, Sun R, Yokoyama WM, Tian Z
The Journal of clinical investigation 2013 Apr;123(4):1444-56
The Journal of clinical investigation 2013 Apr;123(4):1444-56
Difference in Th1 and Th17 lymphocyte adhesion to endothelium.
Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1421-30
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1421-30
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
Cherrier M, Sawa S, Eberl G
The Journal of experimental medicine 2012 Apr 9;209(4):729-40
The Journal of experimental medicine 2012 Apr 9;209(4):729-40
ATP drives lamina propria T(H)17 cell differentiation.
Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K
Nature 2008 Oct 9;455(7214):808-12
Nature 2008 Oct 9;455(7214):808-12
Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.
Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7414-22
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7414-22
Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.
Robays LJ, Maes T, Lebecque S, Lira SA, Kuziel WA, Brusselle GG, Joos GF, Vermaelen KV
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 15;178(8):5305-11
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 15;178(8):5305-11
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR6 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse B220/CD45R APC-conjugated Monoclonal Antibody (Catalog # FAB1217A) and either (A) Rat Anti-Human/Mouse CCR6 PE-conjugated Monoclonal Antibody (Catalog # FAB590P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR6 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (Catalog # FAB4867A) and either (A) Rat Anti-Human/Mouse CCR6 PE-conjugated Monoclonal Antibody (Catalog # FAB590P) or (B) Rat IgG2A Phycoerythrin Isotype Control (Catalog # IC006P). View our protocol for Staining Membrane-associated Proteins.