Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 327206 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#327206, RRID:AB_2298899
- Product name
- PE anti-human Delta Opioid Receptor
- Antibody type
- Monoclonal
- Antigen
- HEK-293/human Delta Opioid Receptor
- Description
- Opioid receptors are the members of seven transmembrane G-protein coupled receptors. At least 3 types of opioid receptors, µ, κ, and δ, have been identified. Human δ-opioid receptor, know as OPRD, DOR, or hDOR, is primarily expressed in brain, especially in the areas of cortex, including olfactory bulb, hippocampus, and amygdale, as well as in basal ganglia and hypothalamus. Human OPRD gene has been mapped at chromosome 1p34.3-p36.1. The endogenous ligands for the OPRD are enkephalins. The third extracellular loop of the OPRD is critical for ligand binding. The ligands binding and signal transduction functions of δ-receptor can be synergized by forming heterodimers with κ-receptor. Activation of opioid receptor inhibits cAMP production, increases phosphodiesterase activity, and results in analgesia and convulsions. Recent studies have indicated that OPRD is involved in the mechanism of heroin dependence.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human Opiod Receptor-transfected cells stained with DOR7D2A4 PE
- Conjugate
- Yellow dye