CELSR2

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Description

Cadherin EGF LAG seven-pass G-type receptor 2

Tissue specificity

Tissue enhanced (brain, skin)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (109249539 - 109275751)

Ensembl ID

ENSG00000143126  (ver. 103.38)

Orthologs

Mouse Celsr2: ENSMUSG00000068740

UniProt

Q9HCU4

neXtProt

NX_Q9HCU4

Human splice variants
Mouse splice variants

Protein structure