APR03402G

antibody from Leading Biology

Targeting: PTPN3 PTPH1

Western blot (Recommended by provider)

Antibody Data

Product number

APR03402G

Provider

Leading Biology

Product name

Phospho-Ser459 Protein Tyrosine Phosphatase H1 Antibody

Antibody type

Polyclonal

Description

Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38γMAPK phosphatase which is mediated through PDZ interaction (Hou et al., 2010). Ras has beendemonstrated to increase both p38γand PTPH1 protein expression, and there is a coupling of increasedp38γand PTPH1 protein expression in primary colon cancer tissues (Hou et al., 2010). Phosphorylation ofPTPH1 at Ser459 leads to PTPH1 stabilization, which plays an important role in Ras oncogenesis and stressresponse (Hou et al., 2012). Additionally, phosphorylation of PTPH1 Ser459 reveals a novel mechanism bywhich MAPK signals through PTPH1 to regulate cellular response (Hou et al., 2012).

Reactivity

Human, Mouse

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.