CABT-B9306

antibody from Creative Diagnostics

Targeting: PTPRB PTPB

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9306

Provider

Creative Diagnostics

Product name

Mouse anti-Human RPTPÉÇ monoclonal antibody, clone 23/SQUQc

Antibody type

Monoclonal

Description

Receptor-type protein-tyrosine phosphatase ÉÇ (RPTPÉÇ or PTPšø) is the first mammalian tyrosine phosphatase to be characterized whose expression is limited to the nervous system. RPTPÉÇ consists of a large extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic domains. Three forms of RPTPÉÇ exist which appear to be derived from alternative splicing. The 9.5 kb and 6.4 kb transcripts encode two transmembrane forms. The 8.5 kb transcript encodes a secreted form of the extracellular domain of RPTPÉÇ. A region of 266 amino acids in the extracellular domain shows a high degree of homology with carbonic anhydrase. This region is very similar to rat brain chondroitin sulfate proteoglycan (3F8 PG) which appears to be the rat homologue of the entire extracellular domain of human RPTPÉÇ. The apparent molecular weight of human RPTPÉÇ is 250 kDa and approaches 300 kDa when the protein is glycosylated. This antibody was generated against a region known to have a high degree of homology to other proteoglycans, such as RPTPÎÛ (75% homology).

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

23/SQUQc

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.